The aim was to assess the blending effect of universal-shade resin-based composites (RBCs) (Omnichroma—OC; Clearfil Majesty Universal–CM; Venus Pearl—V; Transcend—T) used for repair for lithium disilicate blocks. Fifteen parallelepiped-shaped (10.5 × 10.5 × 3 mm) specimens with four cavities (3 mm in diameter and 2 mm in depth) were designed from lithium disilicate CAD/CAM blocks (CEREC Tessera HT A3) and milled. Specimens were then randomly divided into five groups based on the five resin composite materials for cavity restoration (n = 12): Group 1, control group (F); Group 2 (T); Group 3 (OC); Group 4 (V); and Group 5 (CM). After surface conditioning, composite resins were applied to the ceramic surface. Color measurements were taken with a colorimeter in the center of the resin restoration and on the CAD/CAM block. Tristimulus values were converted to CIELab color coordinates and color differences were expressed in ΔE₀₀ units using the CIEDE-2000 formula. F showed significantly better color matching (ΔE₀₀ = 2.51 ± 0.64) in comparison to single-shade RBCs except T (ΔE₀₀ = 2.55 ± 0.64). All groups exceeded perceptibility and acceptability thresholds. The control group presented higher color matching than the single shade universal composites except for Transcend.

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