Joint Diseases and Related Surgery (JDRS), the official journal of the Turkish Joint Diseases Foundation, is an international, peer-reviewed, immediate open access journal. All published articles in JDRS has been free for everyone, without embargo, since 1990.

Opioid, catalase activity, germ cell, malondialdehyde, testicular detorsion, testicular torsion

Purpose: The aim of this study was to investigate the effects of acute systemic topiramate administration on anxiety index and freezing time, plasma estrogen and progesterone levels, and salivary gland immunoglobulin A in a post-traumatic stress disorder rat model. Materials and Methods: A total of eighteen female Wistar rats used in the study were exposed to predatory odor stress. One week later, saline was administered to the control group and 15 µM and 30 µM topiramate to the treatment groups, after which the animals were exposed to the trauma reminder and their behavior was monitored in the elevated plus maze. At the end of the experiment, blood samples were taken, animals were sacrificed, salivary glands were removed immediately after. Results: Topiramate suppressed anxiety index and freezing time in rats with post-traumatic stress disorder at both 15 µM and 30 µM doses compared to the control group. A positive correlation was observed between plasma estrogen level and anxiety index in the control group, and topiramate suppressed this correlation in a dose-dependent manner. Topiramate did not change the plasma progesterone level, but suppressed the salivary gland immunoglobulin A level at the low dose. Conclusion: These findings obtained in our study indicate that topiramate may be effective in the treatment of post-traumatic stress disorder.

Aim: The present study aims to determine the p16 and CD117 expression profiles of melanocytic lesions to investigate immune profiles that may facilitate differential diagnosis of melanoma from benign or potential precursor melanocytic lesions. Materials and Methods: Immunohistochemistry for p16 and CD117 was applied in a total of 81 cases with melanocytic lesions. Results: A significant loss of p16 expression was found in melanoma cases compared to benign and precursor melanocytic lesions (p<0.05). Moreover, a significant loss of p16 expression was also noted in cases of dysplastic nevus compared to those with intradermal nevus (p<0.01). While no CD117 expression was observed in intradermal nevi, high-level expression was seen in cases with Spitz nevus, blue nevus, invasive melanoma and dysplastic nevus (p<0.01). Conclusion: We believe using p16 and CD117 together may provide an important marker combination to aid in distinguishing melanoma from benign lesions and benign lesions from potential precursor melanocytic lesions. Amaç: Bu çalışmada melanositik lezyonların p16 ve CD117 ekspresyon profillerini belirleyerek, melanomun diğer benign ya da potansiyel prekürsör melanositik lezyonlardan ayırıcı tanısını yapmayı kolaylaştıracak immün profillerini saptamayı amaçladık. Gereç ve Yöntem: Seksen bir melanositik lezyon olgusuna immünohistokimya ile p16 ve CD117 uygulandı. Bulgular: Melanom olgularında diğer benign ve prekürsör melanositik lezyonlara kıyasla anlamlı olarak p16 ekpresyon kaybı mevcuttur(p<0.05). Ayrıca displastik nevüs olgularında da intradermal nevüs olgularına göre anlamlı olarak p16 ekspresyonunda kayıp mevcuttur (p<0.01). CD117 ise intradermal nevüslerde eksprese olmaz iken, spitz nevüs, blue nevüs, invaziv melanom ve displastik nevüslerde ise yüksek oranda ekspresyon mevcuttur (p<0.01). Sonuç: p16 ve CD117 belirteçlerinin birlikte kullanıldığı zaman, melanomları benign lezyonlardan ve benign lezyonları potansiyel prekürsör melanositik lezyonlardan ayırımda önemli belirteçler olarak katkı sağlayacağını düşünmekteyiz.

Joint Diseases and Related Surgery (JDRS), the official journal of the Turkish Joint Diseases Foundation, is an international, peer-reviewed, immediate open access journal. All published articles in JDRS has been free for everyone, without embargo, since 1990.