The integration of passenger and freight transport by urban–rural buses is an effective approach to address two critical issues: the inefficiency of parcel delivery services and the financial struggles of public transport operators. This paper studies the county–township–village station location-routing problem for the integration of passenger and freight transport by urban–rural buses, aiming to develop an efficient transport network by establishing rational stations and designing optimal operation routes. A three-level county–township–village station network is proposed for the integration of passenger and freight transport, and a mixed-integer linear programming model is developed, including the constraints of location, allocation, capacity, and routing. A comprehensive series of numerical experiments is conducted on a randomly generated dataset to evaluate the feasibility and advantages of the proposed model. Lastly, key managerial insights are discussed.