Continuous and dense time series of satellite remote sensing data are needed for several land monitoring applications, including vegetation phenology, in-season crop assessments, and improving land use and land cover classification. Supporting such applications at medium to high spatial resolution may be challenging with a single optical satellite sensor, as the frequency of good-quality observations can be low. To optimize good-quality data availability, some studies propose harmonized databases. This work aims at developing an ‘all-in-one’ Google Earth Engine (GEE) web-based workflow to produce harmonized surface reflectance data from Landsat-7 (L7) ETM+, Landsat-8 (L8) OLI, and Sentinel-2 (S2) MSI top of atmosphere (TOA) reflectance data. Six major processing steps to generate a new source of near-daily Harmonized Landsat and Sentinel (HLS) reflectance observations at 30 m spatial resolution are proposed and described: band adjustment, atmospheric correction, cloud and cloud shadow masking, view and illumination angle adjustment, co-registration, and reprojection and resampling. The HLS is applied to six equivalent spectral bands, resulting in a surface nadir BRDF-adjusted reflectance (NBAR) time series gridded to a common pixel resolution, map projection, and spatial extent. The spectrally corresponding bands and derived Normalized Difference Vegetation Index (NDVI) were compared, and their sensor differences were quantified by regression analyses. Examples of HLS time series are presented for two potential applications: agricultural and forest phenology. The HLS product is also validated against ground measurements of NDVI, achieving very similar temporal trajectories and magnitude of values (R² = 0.98). The workflow and script presented in this work may be useful for the scientific community aiming at taking advantage of multi-sensor harmonized time series of optical data.