The fear of death associated with cancer and the side effects of its treatments can have a detrimental psychological impact on breast cancer patients. Early detection and support services play a crucial role in alleviating the expected symptoms of depression, anxiety, and sexual dysfunction. The objective of our study is to assess the levels of depression, anxiety, and sexual dysfunction in breast cancer patients, as well as identify the factors that influence these conditions. The study involved 329 voluntarily participating breast cancer patients who had undergone surgery and were in the follow-up stage. Data were collected from 8 different centers after obtaining ethical approval. The assessment utilized tools such as the Sociodemographic Information Form, Beck Depression and Anxiety Scale, and Arizona Sexual Experiences Scale. Data analysis was performed using SPSS 20. The study included 329 breast cancer patients in the follow-up stage post-surgery. Their average age was 52.7 years (range: 27–83). Results indicated that 33.1% experienced moderate to severe depression, 18.2% reported severe anxiety, and 82.7% scored above 11 on the sexual scale. Factors linked to higher scores were mastectomy, surgical dissatisfaction, insufficient information on sexual side effects, and comorbidities like smoking and diabetes. The study emphasizes the importance of closely monitoring anxiety, depression levels, and sexual side effects in breast cancer treatment. It underscores the need to focus not only on reducing mortality rates but also on supporting patients’ psychological and sexual well-being, ultimately improving their overall quality of life.

Giriş ve Amaç: Küçük hücreli akciğer kanseri (KHAK) tüm akciğer kanserlerinin yaklaşık %15’ini oluşturmaktadır. Küçük hücreli akciğer kanserinde prognoz; yeni kemoterapotik ajanların kullanılması, radyoterapi (RT) tekniklerinin gelişmesi ve profilaktik kraniyal ışınlamanın (PKI) eklenmesi ile tedavi sonuçları iyileşmesine rağmen halen kötüdür. Akciğer kanserinde prognostik faktörlerin önceden belirlenmesi tedavi ve takip açısından çok önemlidir. Bu tür çalışmaların çoğu küçük hücreli dışı akciğer kanserli hastalarla yapıldığı için çalışmamızda küçük hücreli akciğer kanserli olgularımızda tedavi sonuçlarını ve prognostik faktörleri değerlendirdik. Gereç ve Yöntemler: Hastanemizde 2002–2017 yılları arasında tedavi edilen 123 küçük hücreli akciğer kanserli olgu değerlendirmeye alındı. Retrospektif olarak hasta dosyaları tarandı. Bulgular: Hastaların 102’si erkek olup, medyan yaş 61 (29-81) olarak saptandı. Başlangıçta 59 hastada kilo kaybı vardı, en sık şikayet öksürüktü. 72’si (58.5) sınırlı, 51’i (%41,5) yaygın evreydi. Tümör 68 hastada sağ taraf yerleşimliydi. 24 hastada aile öyküsü vardı. 48 hastada ek hastalık ve119’unda sigara öyküsü vardı. Radyoterapi 63 (%51,2) hastada küratif, 60 hastada palyatif olarak uygulandı. 55 hasta radyokemoterapi aldı.79 hastada kemoterapi kür sayısı 5 ve üzerinde olup,44 hastada 4 ve daha az sayıda kür uygulandı.68 hasta PKI aldı. Ortalama izlem süresi 19.2 aydı. Bir yıllık genel sağ kalım%62,2, 2 yıllık sağkalım%30,1 ve genel sağ kalım 15 ay ve progresyonsuz sağkalım %15 olarak bulunmuştur. 59 hastada lokal nüks, 47 hastada uzak metastaz gelişti. Evre, yaş, ECOG, kilo kaybı, kraniyal metastaz gelişmesi, başlangıçta başağrısı, dispne ve kemoterapi kür sayısı; genel sağ kalımda istatistiksel olarak anlamlı bulunmuştur. ECOG, kilo kaybı, cinsiyet ve KT kür sayısı progresyonsuz sağ kalımda anlamlı bulunmuştur. Sonuç: KHAK’nin tedavisinde önemli mesafeler alınmasına karşılık, sağ kalım oranlarında beklenen artış henüz sağlanamamaktadır. Çalışmamızda sağ kalım oranları literatürle uyumludur. PKI’nın sınırlı evrede tedaviye eklenmesi belirgin şekilde beyin metastazını azaltmaktadır. Beyin metastazsız yaygın evre hastalıkta PKI’nın tedaviye eklenmesi genel sağ kalım üzerine etkili bulunmamakla birlikte beyin metastazı gelişme süresinin uzadığı görülmüştür. Küçük hücreli akciğer kanserinde torasik radyoterapi ve PKI uygulamasıyla bir çok çalışmada sağ kalımda artış görülmüş olup, radyoterapinin rolü giderek artmaktadır. Her hasta için potansiyel fayda ve riskler başlangıç tedavisinden önce belirlenmeli ve kişiye özel tedavi planlanmalıdır.

Background: Accurate localization of the lumpectomy cavity is important for breast cancer radiotherapy after breast-conserving surgery (BCS), but the LC localization based on CT is often difficult to delineate accurately. The study aimed to compare CT-defined LC planning to MRI-defined findings in the supine position for higher soft-tissue resolution of MRI. Methods: Fifty-nine breast cancer patients underwent radiotherapy CT planning in supine position followed by MR imaging on the same day. LC was contoured by the radiologist and radiation oncologist together by CT and MRI separately. T2 weighted MR images and tomography findings were combined and the LC volume, mean diameter and the longest axis length were measured after contouring. Subsequently, patients were divided into two groups according to seroma in LC and the above-mentioned parameters were compared. Results: We did not find any statistically significant difference in the LC volume, mean diameter and length at the longest axis between CT and MRI but based on the presence or absence of seroma, statistically significant differences were found in the LC volumes and the length at the longest axis of LC volumes. Conclusion: We believe that the supine MRI in the same position with CT will be more effective for radiotherapy planning, particularly in patients without a seroma in the surgical cavity.

Objective: Our study aims to evaluate the depression and burnout states (according to their sociodemographic characteristic) of Turkish Oncology Physicians (both medical and radiation oncologists) who follow up and treat oncology patients. Materials and methods: Actively working radiation oncology practitioners (n:267)who completed the questionnaire voluntarily were included to the study. A 13-item personal information form was prepared to determine the participants' sociodemographic characteristics. Data were transferred to the IBM SPSS Statistics 23 program using the Maslach Burnout Inventory (MBI), Beck Depression Inventory (BDE). Results: A statistically significant relationship (with both positive and high levels) was found between the beck depression scale score and the emotional exhaustion subscale while a statistically significant association (with bothpositive and middle levels) was found between the Beck depression scale score and the depersonalization subscale, and a statistically significant relationship (with both positive and low levels) was found between the beck depression scale score and the personal success subscale (p<0,05). Conclusion: In our study, depression status and burnout presence were detected in the doctors working in the field of oncology. It is important to take precautions before entering depression and before burnout begins. As a result, the quality of life for physicians will improve, leading to enhanced diagnoses and treatments for cancer patients, as well as fostering positive relationships with both patients and their families

HER2-targeted therapies (trastuzumab, T-DM1) improve outcomes in HER2-positive breast cancer but are associated with cardiotoxicity. Radiotherapy also carr