Introduction: Neuropathic pain occurs in 1% of the population and is difficult to manage. This chronic pain causes psychological distress and impacts patient's quality of life, especially in cancer patients. The aim of this study was to show and compare the efficacy of pregabalin and duloxetine, which are reported in the group of first‐line treatment at European Federation of Neurological Societies (EFNS) guidelines on the pharmacological treatment of neuropathic pain (2010 revision) in lung cancer patients by using visual analogue scale (VAS) and Leeds Assessment of Neuropathic Symptoms and Sign (LANSS).Patients and Methods: A prospective, randomized, open label, 3 month of study was conducted. A total of 44 patients that were diagnosed with neuropathic pain (14 women and 30 men) were included in the study. Patient's LANSS and VAS values were recorded before treatment. Then, 22 patients undergo pregabalin and 22 patients undergo duloxetine therapy. But due to side effects (dizziness, constipation), two patients had stopped to use pregabalin. Their LANSS and VAS values were recorded after 1 and 3 months of therapy.Results: When we compare LANSS and VAS scores before treatment, after 1 and 3 months of treatment with pregabalin and duloxetine, a significant decrease was observed in both groups at the 1 and 3 months (p < .01). Duloxetine is superior to pregabalin in reducing the LANSS scores when we compare two groups.Conclusions: Both duloxetine and pregabalin are effective in the treatment of neuropathic pain of lung cancer patients. And as far as we know, this is the first study comparing the efficacy of duloxetine and pregabalin in the neuropathic pain of lung cancer patients.

The fear of death associated with cancer and the side effects of its treatments can have a detrimental psychological impact on breast cancer patients. Early detection and support services play a crucial role in alleviating the expected symptoms of depression, anxiety, and sexual dysfunction. The objective of our study is to assess the levels of depression, anxiety, and sexual dysfunction in breast cancer patients, as well as identify the factors that influence these conditions. The study involved 329 voluntarily participating breast cancer patients who had undergone surgery and were in the follow-up stage. Data were collected from 8 different centers after obtaining ethical approval. The assessment utilized tools such as the Sociodemographic Information Form, Beck Depression and Anxiety Scale, and Arizona Sexual Experiences Scale. Data analysis was performed using SPSS 20. The study included 329 breast cancer patients in the follow-up stage post-surgery. Their average age was 52.7 years (range: 27–83). Results indicated that 33.1% experienced moderate to severe depression, 18.2% reported severe anxiety, and 82.7% scored above 11 on the sexual scale. Factors linked to higher scores were mastectomy, surgical dissatisfaction, insufficient information on sexual side effects, and comorbidities like smoking and diabetes. The study emphasizes the importance of closely monitoring anxiety, depression levels, and sexual side effects in breast cancer treatment. It underscores the need to focus not only on reducing mortality rates but also on supporting patients’ psychological and sexual well-being, ultimately improving their overall quality of life.

The results of standard chemotherapy in lung cancer are not very satisfactory, so it is important to identify genetic mutations that provide targeted therapies. Recent reports have suggested influences of racial difference on the frequency of mutation in lung cancer. We aimed to determine the frequency and regional distribution of genetic mutations of non-small cell lung cancer (NSCLC) in Turkey. Regional distribution of genetic mutations in lung cancer in Turkey (REDIGMA) study was carried out as a prospective, cross-sectional, observational study in a large number of centers in which lung cancer patients were followed and could perform genetic mutation analysis on patients' biopsy materials. The 703 patients (77.7% male, mean age 63.3 ± 12.5 years) who were diagnosed as NSCLC from 25 different centers were included in the study. Tumor samples from patients were reported as 87.1% adenocarcinoma, 6.4% squamous cell carcinoma and 6.5% other. Mutation tests were found to be positive in 18.9% of these patients. The mutations were 69.9% EGFR, 26.3% ALK, 1.6% ROS and 2.2% PDL. Mutations were higher in women and non-smokers (p<0.000, p<0.001). Again, the frequency of mutations in adenocarcinoma was higher in metastatic disease. There was no difference between the patient's age, area of residence, comorbidity and clinical stage and mutation frequency. Our study revealed that the EGFR mutation rate in Turkey with NSCLC was similar to East European, African-American and Caucasian patients, and was lower than in East Asia.

Giriş ve Amaç: Küçük hücreli akciğer kanseri (KHAK) tüm akciğer kanserlerinin yaklaşık %15’ini oluşturmaktadır. Küçük hücreli akciğer kanserinde prognoz; yeni kemoterapotik ajanların kullanılması, radyoterapi (RT) tekniklerinin gelişmesi ve profilaktik kraniyal ışınlamanın (PKI) eklenmesi ile tedavi sonuçları iyileşmesine rağmen halen kötüdür. Akciğer kanserinde prognostik faktörlerin önceden belirlenmesi tedavi ve takip açısından çok önemlidir. Bu tür çalışmaların çoğu küçük hücreli dışı akciğer kanserli hastalarla yapıldığı için çalışmamızda küçük hücreli akciğer kanserli olgularımızda tedavi sonuçlarını ve prognostik faktörleri değerlendirdik. Gereç ve Yöntemler: Hastanemizde 2002–2017 yılları arasında tedavi edilen 123 küçük hücreli akciğer kanserli olgu değerlendirmeye alındı. Retrospektif olarak hasta dosyaları tarandı. Bulgular: Hastaların 102’si erkek olup, medyan yaş 61 (29-81) olarak saptandı. Başlangıçta 59 hastada kilo kaybı vardı, en sık şikayet öksürüktü. 72’si (58.5) sınırlı, 51’i (%41,5) yaygın evreydi. Tümör 68 hastada sağ taraf yerleşimliydi. 24 hastada aile öyküsü vardı. 48 hastada ek hastalık ve119’unda sigara öyküsü vardı. Radyoterapi 63 (%51,2) hastada küratif, 60 hastada palyatif olarak uygulandı. 55 hasta radyokemoterapi aldı.79 hastada kemoterapi kür sayısı 5 ve üzerinde olup,44 hastada 4 ve daha az sayıda kür uygulandı.68 hasta PKI aldı. Ortalama izlem süresi 19.2 aydı. Bir yıllık genel sağ kalım%62,2, 2 yıllık sağkalım%30,1 ve genel sağ kalım 15 ay ve progresyonsuz sağkalım %15 olarak bulunmuştur. 59 hastada lokal nüks, 47 hastada uzak metastaz gelişti. Evre, yaş, ECOG, kilo kaybı, kraniyal metastaz gelişmesi, başlangıçta başağrısı, dispne ve kemoterapi kür sayısı; genel sağ kalımda istatistiksel olarak anlamlı bulunmuştur. ECOG, kilo kaybı, cinsiyet ve KT kür sayısı progresyonsuz sağ kalımda anlamlı bulunmuştur. Sonuç: KHAK’nin tedavisinde önemli mesafeler alınmasına karşılık, sağ kalım oranlarında beklenen artış henüz sağlanamamaktadır. Çalışmamızda sağ kalım oranları literatürle uyumludur. PKI’nın sınırlı evrede tedaviye eklenmesi belirgin şekilde beyin metastazını azaltmaktadır. Beyin metastazsız yaygın evre hastalıkta PKI’nın tedaviye eklenmesi genel sağ kalım üzerine etkili bulunmamakla birlikte beyin metastazı gelişme süresinin uzadığı görülmüştür. Küçük hücreli akciğer kanserinde torasik radyoterapi ve PKI uygulamasıyla bir çok çalışmada sağ kalımda artış görülmüş olup, radyoterapinin rolü giderek artmaktadır. Her hasta için potansiyel fayda ve riskler başlangıç tedavisinden önce belirlenmeli ve kişiye özel tedavi planlanmalıdır.

Objective: Breast cancer is common among women aged 65 and over. There is a significant lack of evidence regarding the treatment of breast cancer in patients in this age group due to the rare inclusion of these patients in clinical studies. However, it is known that survival in elderly patients with breast cancer is significantly reduced in those not receiving standard therapy. Several factors, including patients' comorbidities, performance status, life expectancy, and tumor pathological and molecular characteristics, can affect the outcomes of treatment. In this study, we aimed to update the knowledge in this field by assessing these factors among the geriatric population in our multicenter dataset. Methods: This retrospective study analyzed data from 335 breast cancer patients aged 65 and over who received adjuvant radiotherapy at five oncology centers (Kartal Dr. Lutfi Kirdar Training and Research Hospital, Istanbul, Meram Medical Faculty - Necmettin Erbakan University, Konya, Prof. Dr. Cemil Tascioglu City Hospital, Istanbul, Umraniye Training and Research Hospital, Istanbul, and Istanbul Oncology Hospital, Istanbul) between May 2010 and September 2022. Demographic, clinical, and pathological data were collected, including age, gender, clinical symptoms, tumor characteristics, treatment approaches, and outcomes. Statistical analyses, including descriptive statistics, Kaplan-Meier analysis, log-rank test, and Cox regression analysis, were performed using IBM SPSS Statistics for Windows, Version 22 (Released 2013; IBM Corp., Armonk, New York, United States), with a significance level of p < 0.05. Results: The tumor characteristics and survival time of 335 breast cancer patients were examined. In theresults, performance status, T stage, and perineural invasion were found to be factors affecting the survivalof elderly breast cancer patients. In multivariate analysis, it was seen that performance status played animportant role as an independent prognostic factor. Conclusion: The treatment of breast cancer in the geriatric age group necessitates a personalized approach, taking into account the patient's overall health status, life expectancy, and comorbiditie