The 1.1 Ga Mesoproterozoic Midcontinent rift hosts the Eagle, Eagle East, and Tamarack Ni-Cu-PGE deposits and Embayment Prospect. These deposits are hosted by ultramafic igneous rocks and have some of the highest Ni-Cu grades on Earth. We use new bulk-rock data and published datasets (bulk-rock, mineral chemistry, and isotopic analyses) to examine major, minor, and trace element trends of both Midcontinent rift-related alkaline and tholeiitic intrusions. In addition, we compare the geochemical data to local kimberlite-hosted lower-crustal xenoliths and local igneous (Archean) and sedimentary (Paleoproterozoic) country rocks. We found the peridotite magma compositions dominantly consist of primitive mantle compositions with varying abundances of subduction-related components, alkaline-transitional melts, and local country rock contaminates (e.g., Baraga and Animikie Basin sediments). The subduction-related components are interpreted to be derived from previous Archean and Paleoproterozoic subduction events and likely hosted within the sub-continental lithospheric mantle. Importantly, these subduction-related components are also interpreted to have acted as oxidizing agents within the melt, stabilizing sulfate (+2 FMQ (fayalite–magnetite–quartz) to FMQ) while inhibiting sulfide crystallization as the magma ascended through ~50 km of the Superior craton. This study largely corroborates the previous findings with respect to the contribution of local country rock contamination to the Eagle–Tamarack peridotite host rocks, which is estimated to be minimal (<5%). However, the incorporation of <5% reductive pelitic siltstone contamination results in strong shifts in the oxygen fugacity of the peridotite melt, from +2 FMQ to slightly below FMQ, as determined from spinel Fe³⁺/∑Fe ratios. This shift in oxygen fugacity resulted in the transition from total sulfate (+2 FMQ) to sulfate + sulfide (<+2 FMQ to FMQ) to total sulfide (<FMQ). This shift in oxygen fugacity is a key contributor to the formation of Ni-Cu-PGE-rich massive sulfides within the Eagle peridotite. This study presents an expanded geochemical interpretation for the exploration of Midcontinent rift-related Ni-Cu-PGE deposits to include peridotites with subduction-like signatures and contaminated via <5% reductive sedimentary country rocks.