Plant-derived compounds offer immense therapeutic potential, yet many suffer from limited solubility, instability, and poor bioavailability, restricting their clinical application. Curcumin, a polyphenol extracted from Curcuma longa, is one such molecule, with proven antioxidant and anti-inflammatory properties. To overcome its pharmacokinetic limitations, we developed Jamamina, a sustainable nanostructured lipid carrier (NLC) system incorporating curcumin and a Natural Deep Eutectic Solvent (NaDES) phase composed of malic acid and betaine. The bioinspired formulation, based on Amazonian tucumã butter and jambu oil, achieved high encapsulation efficiency (>80%) and curcumin amorphization, enhancing solubility and colloidal stability. In vitro assays with L132 demonstrated potent antioxidant activity (DPPH), a significant reduction in pro-inflammatory cytokines (TNF-α and IL-6), and upregulation of IL-10. The system also suppressed MMP-2/9 activity and preserved cytoskeletal integrity under oxidative stress. These findings highlight Jamamina as a multifunctional, eco-friendly nanoplatform that enables the pharmacological application of plant-derived curcumin, representing a promising platform for modulating redox balance and investigating inflammation in epithelial-like contexts.

This study evaluates a nanostructured lipid carrier (NLC) formulation incorporating taperebá (Spondias mombin L.) peel extract and natural deep eutectic solvents (NaDES) as a sustainable antioxidant and anti-inflammatory platform for skin health. The peel extract, rich in polyphenols and carotenoids, was combined with NaDES-based lipids to improve stability and biocompatibility. The NLC-TAP-NaDES demonstrated an average particle size of approximately 150 nm. Human keratinocytes (HaCat) and melanocytes (SH-4) were used to assess cytotoxicity, oxidative stress, and cytokine modulation. NLC-TAP-NaDES showed low toxicity, preserved cell morphology, and significantly reduced superoxide and hydroxyl radicals under hydrogen peroxide stress. The formulation also modulated key cytokines: TNF-α increased under basal conditions, supporting angiogenesis, while IL-6 and IFN-γ were downregulated in keratinocytes, suggesting balanced inflammation and improved barrier function. These findings indicate that NLC-TAP-NaDES provides oxidative protection and modulates inflammatory signaling in skin cells, supporting its potential as a sustainable platform for cosmetic and dermatological applications derived from agricultural byproducts.

The transition from predatory extractive economies to high-technology systems centered on the standing forest paradigm represents a defining sustainability challenge for the Global South. This integrative review establishes a novel socio-technical and technological architecture, conceptualized as Amazonian Nanobioeconomy 5.0, by critically synthesizing the convergence of the Amazonian lipid pharmacopeia, Natural Deep Eutectic Solvents (NaDESs), and Artificial Intelligence/Machine Learning (AI/ML) optimization. We critically evaluate how data-driven green nanomanufacturing can overcome the empirical trial-and-error bottlenecks and severe chemical variability inherent to native biodiversity oils and butters. The integration of predictive algorithms—such as tree-based models and Bayesian optimization—with eco-friendly extraction media enables the rational design of solid lipid nanoparticles (SLNs) and Nanostructured Lipid Carriers (NLCs) while accelerating their translation across the biotechnological “Valley of Death”. Under the Safe-and-Sustainable-by-Design (SSbD) framework, this convergence offers a composition-dependent green alternative to harmful petrochemical volatile organic compounds, fosters circular biorefineries, and minimizes the global environmental footprint of advanced nanopharmaceuticals and cosmeceuticals. Finally, we articulate how this digital and green deep-tech infrastructure must be non-negotiably tethered to strict territorial governance, fair benefit-sharing, and epistemic justice to prevent data colonialism and foster a truly just planetary transition.