Background/Objectives: Postoperative new-onset atrial fibrillation (AF) (PNOAF) is the most common complication after coronary artery bypass graft (CABG), and its incidence has been reported as up to 50% in studies. In this study, we investigated whether there was a relationship between PNOAF and the neutrophil percentage to albumin ratio (NPAR) levels after on-pump CABG. Methods: A total of 454 patients who underwent CABG were included in the study. NPAR was calculated by dividing the neutrophil count by the albumin value. Results: It was determined that 93 patients developed PNOAF (20.4%). When the patient groups that developed and did not develop PNOAF were compared in terms of laboratory findings, C-reactive protein (CRP) values (4.0 mg/L (2.8–7.9) vs. 2.9 mg/L (1.1–6.7), <0.001), neutrophil/lymphocyte ratio (NLR) (2.2 (1.2–4.2) vs. 1.4 (0.7–3.1), <0.001), platelets-to-lymphocyte ratio (112 (72–177) vs. 92 (69–122), <0.001) and NPAR (2.29 (1.68–3.8) vs. 1.09 (0.79–1.81), <0.001), were found to be statistically significantly higher in the group that developed PNOAF. ROC analysis showed that the cut-off value for NPAR for the development of PNOAF was 1.86 with 78% sensitivity and 72% specificity (area under the ROC curve = 0.778, 95% CI (0.728–0.828), p < 0.001). Conclusions: NPAR, which can be detected by a simple venous blood test, has shown a strong predictive value for PNOAF in patients with CABG.

Background and Objectives: Carotid artery stenosis is an inflammatory vascular disease closely linked to atherosclerosis and associated with inflammatory biomarkers. The neutrophil/albumin ratio (NAR) is a novel promising biomarker in assessing cardiovascular disease severity. This study aimed to evaluate the relationship between NAR and lesion severity in patients with carotid artery stenosis. Materials and Methods: This retrospective, single-center, comparative study included 625 asymptomatic patients who underwent digital subtraction angiography (DSA) for suspected high-grade carotid artery stenosis between 2012 and 2022. Patients were classified into two groups based on stenosis severity: critical carotid artery stenosis (≥70% stenosis) and non-critical carotid artery stenosis (<70%). Only asymptomatic patients were included; patients with symptoms were excluded. NAR was calculated preoperatively as neutrophil count divided by serum albumin. Additional inflammatory markers, such as neutrophil–lymphocyte ratio (NLR) and C-reactive protein (CRP) to albumin ratio (CAR), were also analyzed. Results: Severe carotid artery stenosis was detected in 191 of the patients who underwent DSA. Individuals in the critical carotid artery stenosis group were older and had a higher prevalence of diabetes mellitus and hypertension (51 (45–57) vs. 60 (54–68), p < 0.001; 143 vs. 83, p = 0.025; 193 vs. 104, respectively, p = 0.021), as well as higher neutrophil counts (4.3 (3.2–6.2) vs. 8.1 (4.9–12.5), p < 0.001), NLR (2.2 (1.4–3.2) vs. 4.2 (2.3–8.9), p < 0.001), while CRP (3.8 (1.8–8) vs. 5.7 (3.6–7.6), p = 0.005) and CAR (0.9 (0.5–1.9) vs. 1.6 (0.8–2.1), p < 0.001) values were significantly higher. NAR was higher in patients of the critical carotid artery stenosis group than the non-critical (1.1 (0.8–1.6) vs. 2.1 (1.4–3.2), p < 0.001). Multivariate analysis identified NAR as an independent predictor of carotid artery stenosis (Odds Ratio [OR]: 3.432; 95% Confidence Interval [CI]: 2.116–5.566; p < 0.001). The best cut-off value of NAR for predicting critical carotid artery stenosis was 1.47, which provided 73.8% sensitivity and 70.5% specificity. Conclusions: NAR, which can be easily measured through a simple blood test, demonstrated moderate sensitivity and specificity in predicting critical carotid artery stenosis, suggesting its potential role as a supportive marker in clinical risk assessment.

Cardiovascular diseases cause the highest global mortality rates and are often treated with surgical interventions such as stent or vascular plug placement. However, in‐stent restenosis develops over time depending on the material composition and interactions with body fluids. Current strategies to address restenosis include balloon angioplasty or placing a secondary stent at the same site. A key concern with overlapping stents is the increasing risk of galvanic corrosion, as most cardiovascular stents have metallic composition. This study examines galvanic corrosion rates in different vascular stent and plug combinations using electrochemical corrosion characterization techniques. Three metallic vascular specimens with varying compositions are evaluated. The specimens are immersed in simulated body fluid at 37°C under individual and overlapping conditions. Electrochemical impedance spectroscopy and current density measurements, conducted via potentiostat, provide insights into the corrosion behavior of each specimen configuration. Additionally, inductively coupled plasma mass spectrometry quantifies metal ion release through SBF samples. Results show that combining dissimilar materials in overlapping placements significantly increases galvanic corrosion and metal ion release. The corrosion current density (i_corr) significantly increased from 11.75 μA/cm² in the individual bare‐metallic stent to 522.3 μA/cm² in the stent‐on‐plug configuration. A similar increase was observed in the stent‐on‐stent configuration, with an i_corr of 132.6 μA/cm². These results corresponded with notable decreases in electrochemical impedance and polarization resistance, measured as low as 0.039 kΩ (Z_T) and 0.057 kΩ cm² (R_P) for the stent‐on‐plug system. Consequently, the calculated corrosion rate escalated to 2254 μm/year, with a mass loss reaching 42.22 mg/cm²·year. ICP‐MS analysis supported these findings, showing the highest levels of metal ion release in the stent‐on‐plug configuration, with 23.86 ppm of Ni and 0.41 ppm of Cr. These findings highlight the importance of stent‐material selection in reducing corrosion‐related complications. Implementing material‐specific strategies in secondary stent placement can lower the risks of inflammatory host response, stent failure, and their long‐term effects.

OBJECTIVE: Coronary artery disease is still one of the leading health problems. This causes an increase in the diagnosis and treatment procedures for heart diseases. However, it also causes an increase in complications associated with these procedures. One of these complications is pseudoaneurysms. In this study, we aimed to discuss whether hematological and biochemical parameters can be useful in predicting the development of pseudoaneurysm according to the results of peripheral whole blood counts taken before coronary angiography in patients who underwent pseudoaneurysm surgery in our clinic.MATERIAL AND METHODS: The data of 7368 patients who underwent elective coronary angiography with a preliminary diagnosis of coronary artery disease in our hospital between January 2017 and December 2019 were retrospectively reviewed. Data of 88 patients who met the inclusion criteria in our study were examined.RESULTS: Pseudoaneurysm was more frequently located in the male gender (% 60), right lower externity (% 76.4) and the common femoral artery (%71.4). When compared to Group 1, in Group 2, which developed pseudoaneurysm, The patients in group 2 who developed pseudoaneurysm compared to group 1, white blood cell count (WBC) (p: 0.042), Neutrophil to Lymphocite Ratio (NLR) (p: 0.029) and blood urea nitrogen (BUN) (p: 0.050) values were higher before the procedure, Hemoglobin (Hb) (p<0.001), Hematocrit (htc) (p<0.001), and albumin (p: 0.026) values were lower and there was a statistically significant difference. There was no statistically significant difference between Platelet to Platecrite Ratio (PPR) (p: 0.205), Platelet to Neutrophil Ratio (PNR) (p: 0.205), platelet (p: 0.103), total protein (p: 0.061), creatine (p:0.060) and Platecrit (p: 0.151) values.

Objective: Hypercoagulability, called thrombophilia, has a vital role in the development of deep vein thrombosis. During the healing process of patients with thrombosis, the recanalization process in deep veins takes longer in some patients. This study was designed to investigate the role of thrombophilia in this critical process, considering that thrombophilia may be one of the reasons for the prolonged recanalization period. Method: The study was retrospectively analyzed in 118 patients with deep vein thrombosis. Patients were grouped according to thrombophilia or not. Patients were divided into early and late recanalization groups according to the recanalization status on ultrasonography at the sixth month. The thrombophilia status of these groups was evaluated. Results: 62 of the patients were female, and 56 were male. The mean age was 41.92 ± 10.26 years. Thrombophilia was more common in women. There was a significant difference between the mean age and thrombophilia status; the mean age was lower in the thrombophilia group ( p = .029). No statistically significant difference was found between age and recanalization times ( p = 0, 274). Recurrence rates were also higher in the F5 Leiden and Protein-S deficiency group. Conclusion: The presence of thrombophilia affects patients’ recanalization time and, therefore, suggests the need to reevaluate treatment strategies.

Aims: Arteriovenous fistulas (AVF) are the most commonly used vascular access route for hemodialysis (HD) in patients with end-stage renal disease. The most significant cause of AVF dysfunction is stenosis and post-stenotic thrombosis. Fistula stenosis arises from neointimal hyperplasia and various inflammatory factors. Several inflammatory markers have been studied in relation to AVF loss. This study aims to provide a comprehensive perspective on this globally prevalent health issue by examining the association between the continuity of surgically created AVFs and the patients' clinical factors, inflammatory markers, and biochemical parameters. Methods: A total of 146 patients were included in the study. All patients underwent preoperative examination of the upper extremity arterial and venous systems to confirm normal circulation. Patients with suitable arterial and venous structures underwent radiocephalic AVF creation at the wrist level. AVFs that achieved adequate flow and allowed for HD were considered matured. Results: Of the patients, 83 were male and 63 were female. The mean age of the patient group was 58.9 ± 11.41 years, with a minimum age of 30 and a maximum of 77 years. Male sex, low body mass index (BMI), antiplatelet use, and low neutrophil-to-lymphocyte ratio (NLR) and red cell distribution width (RDW) values were positively associated with AVF maturation. However, age, smoking status, type of anesthesia, diabetes, hypertension, and other blood parameters were not significantly associated with AVF maturation. Conclusion: Our study demonstrated that low maturation rates of AVFs were associated with high NLR and RDW values. In addition, antiplatelet use, male sex, and low BMI were found to be associated with AVF maturation.