Karthik Srinivasan

Dr. Karthik Srinivasan

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Research Focus & Metrics

Academic Career Length

14Years (2013-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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20 August 2018 in Occupational and Environmental Medicine
Verified
Journal Article
Open access
PDF file
CLCasey M Lindberg
Casey M Lindberg
KSKarthik Srinivasan
Karthik Srinivasan
BGBrian Gilligan
Brian Gilligan
JRJavad Razjouyan
Javad Razjouyan
HLHyoki Lee
Hyoki Lee
ESEsther M. Sternberg
Esther M. Sternberg
Objective Office environments have been causally linked to workplace-related illnesses and stress, yet little is known about how office workstation type is linked to objective metrics of physical activity and stress. We aimed to explore these associations among office workers in US federal office buildings. Methods We conducted a wearable, sensor-based, observational study of 231 workers in four office buildings. Outcome variables included workers’ physiological stress response, physical activity and perceived stress. Relationships between office workstation type and these variables were assessed using structural equation modelling. Results Workers in open bench seating were more active at the office than those in private offices and cubicles (open bench seating vs private office=225.52 mG (31.83% higher on average) (95% CI 136.57 to 314.46); open bench seating vs cubicle=185.13 mG (20.16% higher on average) (95% CI 66.53 to 303.72)). Furthermore, workers in open bench seating experienced lower perceived stress at the office than those in cubicles (−0.27 (9.10% lower on average) (95% CI −0.54 to −0.02)). Finally, higher physical activity at the office was related to lower physiological stress (higher heart rate variability in the time domain) outside the office (−26.12 ms/mG (14.18% higher on average) (95% CI −40.48 to −4.16)). Conclusions Office workstation type was related to enhanced physical activity and reduced physiological and perceived stress. This research highlights how office design, driven by office workstation type, could be a health-promoting factor.

21 October 2019 in Indoor Air
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Journal Article
Open access
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JRJavad Razjouyan
Javad Razjouyan
HLHyoki Lee
Hyoki Lee
BGBrian Gilligan
Brian Gilligan
CLCasey Lindberg
Casey Lindberg
HNHung Nguyen
Hung Nguyen
Bijan NajafiBijan Najafi
Bijan Najafi
This study offers a new perspective on the role of relative humidity in strategies to improve the health and wellbeing of office workers. A lack of studies of sufficient participant size and diversity relating relative humidity (RH) to measured health outcomes has been a driving factor in relaxing thermal comfort standards for RH and removing a lower bound for dry air. We examined the association between RH and objectively measured stress responses, physical activity (PA), and sleep quality. A diverse group of office workers (n = 134) from four well‐functioning federal buildings wore chest‐mounted heart rate variability monitors for three consecutive days, while at the same time, RH and temperature (T) were measured in their workplaces. Those who spent the majority of their time at the office in conditions of 30%‐60% RH experienced 25% less stress at the office than those who spent the majority of their time in drier conditions. Further, a correlational study of our stress‐response suggests optimal values for RH may exist within an even narrower range around 45%. Finally, we found an indirect effect of objectively‐measured poorer sleep quality, mediated by stress responses, for those outside this range.

13 December 2017 in IEEE Journal of Biomedical and Health Informatics
Verified
Journal Article
Closed access
KSKarthik Srinivasan
Karthik Srinivasan
FCFaiz Currim
Faiz Currim
SRSudha Ram
Sudha Ram
Data mining models for high-cost patient encounter prediction at the point-of-admission (HPEPP) in inpatient wards are scarce in the literature. This is due to the lack of availability of relevant features at such an early stage of treatment. In this study, we create a disease co-occurrence network (DCN) using a subset of the state inpatient database of Arizona. We explore this network for community formation and structural properties to create new input features for HPEPP models. Tree-based data mining models are trained using input feature sets including these new network features, and distinct disease communities in the DCN are identified. We propose community membership and high-cost propensity scores as two network-based features for HPEPP modeling. We compare the performance of models with different input feature sets and find that the new features significantly improve the accuracy sensitivity and specificity of prediction models. This model has the potential to improve targeted care management and reduce health care expenditure.

1 March 2013 in Retina
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Journal Article
Closed access
DSDhananjay Shukla
Dhananjay Shukla
JKJay Kalliath
Jay Kalliath
KSKarthik Srinivasan
Karthik Srinivasan
NNNithya Neelakantan
Nithya Neelakantan
ARAnand Rajendran
Anand Rajendran
UBUmesh C. Behera
Umesh C. Behera
To compare the outcomes of vitrectomy with or without internal limiting membrane peeling for rhegmatogenous retinal detachment and coexisting macular hole. Thirty-one consecutive patients (31 eyes) with macula-off retinal detachment, peripheral breaks and a coexisting macular hole were prospectively enrolled over a 3-year period. All patients underwent vitrectomy with encirclage and gas or silicone oil tamponade. The 17 patients who underwent internal limiting membrane peeling for macular hole constituted Group A and the remaining 14 patients constituted Group B. The main outcome measures were change in best-corrected visual acuity, retinal reattachment, macular hole closure, and type of macular hole closure. The two groups were comparable in preoperative demographics and clinical parameters. The retinal reattachment rate was 100% in both the groups. Macular hole closed in 14 of 17 eyes (82.4%) in Group A and 13 of 14 eyes (92.9%) in Group B (P = 0.607). A flat-open configuration of macular hole closure was observed in 8 of 14 eyes (57%) in Group A and 3 of 13 eyes (27.5%) in Group B (P = 0.188). Mean logarithm of the minimum angle of resolution best-corrected visual acuity improved to 1.0 ± 0.3 (20/200; range, 0.8-1.7) in Group A and 0.6 ± 0.2 (20/80; range, 0.3-1.1) in Group B (P < 0.0001). Ten patients achieved best-corrected visual acuity of ≥ 20/80 in Group B and none in Group A (P < 0.0001). The anatomical and visual outcomes of vitrectomy without internal limiting membrane peeling in macular hole in retinal detachment were similar to or better than the outcomes obtained with internal limiting membrane peeling.

13 January 2023 in npj Digital Medicine
Verified
Journal Article
Open access
PDF file
KSKarthik Srinivasan
Karthik Srinivasan
FCFaiz Currim
Faiz Currim
CLCasey M. Lindberg
Casey M. Lindberg
JRJavad Razjouyan
Javad Razjouyan
BGBrian Gilligan
Brian Gilligan
SRSudha Ram
Sudha Ram
We conducted a field study using multiple wearable devices on 231 federal office workers to assess the impact of the indoor environment on individual wellbeing. Past research has established that the workplace environment is closely tied to an individual’s wellbeing. Since sound is the most-reported environmental factor causing stress and discomfort, we focus on quantifying its association with physiological wellbeing. Physiological wellbeing is represented as a latent variable in an empirical Bayes model with heart rate variability measures—SDNN and normalized-HF as the observed outcomes and with exogenous factors including sound level as inputs. We find that an individual’s physiological wellbeing is optimal when sound level in the workplace is at 50 dBA. At lower (50dBA) amplitude ranges, a 10 dBA increase in sound level is related to a 5.4% increase and 1.9% decrease in physiological wellbeing respectively. Age, body-mass-index, high blood pressure, anxiety, and computer use intensive work are person-level factors contributing to heterogeneity in the sound-wellbeing association.

Verified
Journal Article
Open access
PDF file
SRSunita S. Rao
Sunita S. Rao
Norma JumaNorma Juma
Norma Juma
KSKarthik Srinivasan
Karthik Srinivasan
This study investigated how specific sustainability topics disclosed in standalone sustainability reports influence firm value and whether third-party assurance moderates this relationship. Drawing on signaling, agency, stakeholder, and legitimacy theories, we applied latent Dirichlet allocation (LDA) to extract latent topics from U.S. corporate sustainability reports. We analyzed their impact on Tobin’s Q using panel regressions and supplement our findings with discrete Bayesian networks (DBNs) and Shapley additive explanations (SHAP) to capture non-linear patterns. We identified six core topics: environmental impact, sustainable consumption, daily necessities, socio-economic impact, healthcare, and operations. The results revealed that topics of healthcare and daily necessities have immediate and sustained positive effects on firm value, while environmental and socio-economic impact topics demonstrate lagged effects, primarily two years after disclosure. The presence of assurance, however, produces mixed outcomes: it enhances credibility in some cases, but reduces firm value in others, especially when applied to environmental and socio-economic disclosures. This suggests a dual signaling effect of assurance, potentially increasing investor scrutiny when gaps in performance are highlighted. Our findings underscore the importance of topic selection, consistency in reporting, and strategic application of assurance in ESG communications to maintain stakeholder trust and market value.