Wound healing is the dynamic tissue regeneration process replacing devitalized and missing tissue layers. With the development of photomedicine techniques in wound healing, safe and noninvasive photobiomodulation therapy is receiving attention. Effective wound management in photobiomodulation is challenged, however, by limited control of the geometrical mismatches on the injured skin surface. Here, adhesive hyaluronic acid–based gelatin nanofibrous membranes integrated with multiple light-emitting diode (LED) arrays are developed as a skin-attachable patch. The nanofibrous wound dressing is expected to mimic the three-dimensional structure of the extracellular matrix, and its adhesiveness allows tight coupling between the wound sites and the flexible LED patch. Experimental results demonstrate that our medical device accelerates the initial wound healing process by the synergetic effects of the wound dressing and LED irradiation. Our proposed technology promises progress for wound healing management and other biomedical applications.

Implantable electronic devices are driving innovation in modern medical technology and have significantly improved patients’ quality of life. This review comprehensively analyzes the latest technological trends in implantable electronic devices used in major organs, including the heart, brain, and skin. Additionally, it explores the potential for application in the gastrointestinal system, particularly in the field of biliary stents, in which development has been limited. In the cardiac field, wireless pacemakers, subcutaneous implantable cardioverter-defibrillators, and cardiac resynchronization therapy devices have been commercialized, significantly improving survival rates and quality of life of patients with cardiovascular diseases. In the field of brain–neural interfaces, biocompatible flexible electrodes and closed-loop deep brain stimulation have improved treatments of neurological disorders, such as Parkinson’s disease and epilepsy. Skin-implantable devices have revolutionized glucose management in patients with diabetes by integrating continuous glucose monitoring and automated insulin delivery systems. Future development of implantable electronic devices incorporating pressure or pH sensors into biliary stents in the gastrointestinal system may significantly improve the prognosis of patients with bile duct cancer. This review systematically organizes the technological advances and clinical outcomes in each field and provides a comprehensive understanding of implantable electronic devices by suggesting future research directions.

Molecularly imprinted polymer (MIP) biosensors offer an attractive strategy for selective biomolecule detection, yet imprinting proteins with structural fidelity remains a major challenge. In this work, we present a rationally designed electrochemical biosensor for matrix metal-loproteinase-8 (MMP-8), a key salivary biomarker of periodontal disease. By integrating graphene oxide (GO) with electropolymerized poly(eriochrome black T, EBT) films on screen-printed carbon electrodes, the partially reduced GO interface enhanced electrical conductivity and facilitated the formation of well-defined poly(EBT) films with re-designed polymerization route, while template extraction generated artificial antibody-like sites capable of specific protein binding. The MIP-based electrodes were comprehensively validated through morphological, spectroscopic, and electrochemical analyses, demonstrating stable and selective recognition of MMP-8 against structurally similar interferents. Complementary density functional theory (DFT) modeling revealed energetically favorable interactions between the EBT monomer and catalytic residues of MMP-8, providing molecular-level insights into imprinting specificity. These experimental and computational findings highlight the importance of rational monomer selection and nanomaterial-assisted polymerization in achieving selective protein imprinting. This work presents a systematic approach that integrates electrochemical engineering, nanomaterial interfaces, and computational validation to address long-standing challenges in protein-based MIP biosensors. By bridging molecular design with practical sensing performance, this study advances the translational potential of MIP-based electrochemical biosensors for point-of-care applications.

We present an integrated microelectrode array (MEA) platform for high‐precision electrophysiological characterization of patient‐derived 3D cardiac organoids (COs), enabling dynamic recordings from both healthy and Duchenne muscular dystrophy (DMD) “mini‐hearts.” A deformable MEA, fabricated by photolithographic patterning of support layers and microelectrodes, is conformally assembled onto a customized scoop‐slide well. The concave geometry enables passive self‐alignment of millimeter‐scale COs within a multichannel electrode array, allowing simultaneous extracellular field potential (EFP) recording and video‐based motion analysis. Using COs derived from human induced pluripotent stem cells of healthy donors and a DMD patient, we resolved region‐specific EFP waveforms, which were validated by calcium imaging. DMD COs exhibited severe arrhythmic firing and aberrant waveform morphologies, in contrast to the stable, isochronal rhythms of healthy controls. Single‐cell transcriptomic analysis revealed a pathological DMD signature marked by excessive extracellular matrix accumulation and disorganized cardiac architecture, contributing to conduction heterogeneity. Pharmacological challenge with the hERG blocker E‐4031 prolonged field potential duration in normal COs but triggered disorganized arrhythmogenic storms in DMD COs. By overcoming the limitations of rigid interfaces and ensuring structural preservation with stable impedance coupling, the presented platform provides a robust biointerface for disease phenotyping, drug screening, and mechanistic interrogation of 3D cardiac tissues.