There is a huge risk of dam failure during the operation of tailings ponds. Domestic and foreign scholars have conducted extensive research on the assessment and prevention of dam failure risks during the operation of tailings ponds, but there are still many shortcomings. On the basis of exploring the key issues of dam failure risk assessment during the operation of tailings dams, this paper establishes a comprehensive evaluation index system for dam failure risk during the operation of tailings dams based on ten principles including scientificity, systematicity, and operability. By exploring the use of the change statistical mapping method, we can determine the weight of indicators. A risk assessment model was constructed using the fuzzy comprehensive evaluation method; compared to the traditional fuzzy comprehensive evaluation method, this model determines weights in a more extensive and scientific manner. The scientific and effective nature of the model was verified through case analysis of the Shouyun Iron Mine and Shangyu Tailings Reservoir in Beijing. Finally, in response to the risk of dam failure during the operation of tailings ponds, scientific prevention and control measures were proposed from four aspects: personnel risk prevention and control, inherent risk prevention and control of tailings ponds, environmental factor risk prevention and control, and management risk prevention and control.