Background/Objectives: NPC is a radiosensitive malignancy with high recurrence rates despite therapeutic advances. This study aimed to identify radiologic and metabolic predictors of recurrence in newly diagnosed NPC by integrating MRI and ¹⁸F-FDG PET/CT parameters. Methods: Fifty-two patients with biopsy-proven, previously untreated NPC who underwent pre-treatment MRI and ¹⁸F-FDG PET/CT were retrospectively analyzed. Local tumor features, nodal status, and response patterns were evaluated using MRI and PET/CT-derived metrics: SUVmax, SUVmean, SUVpeak, MTV, and TLG. The post-treatment MRI response was categorized into six patterns. Univariate and multivariate analyses were performed to identify independent predictors. Results: Recurrence occurred in 27% of patients. Based on the multivariate analysis, PNI, extensive PPS invasion, GTV, and metastatic LN count were identified as independent predictors of recurrence (PNI: OR = 1.60, p = 0.029; PPS: OR = 1.23, p = 0.027; GTV: OR = 1.08, p = 0.042; LN count: OR = 1.20, p = 0.031). PNI and PPS invasion were significantly associated with local failure (HR = 8.21, p = 0.008 and HR = 3.52, p = 0.043, respectively). GTV was independently associated with an increased risk of local (HR = 1.14, p = 0.021) and distant recurrence (HR = 1.19, p = 0.024). The presence of metastatic disease at diagnosis (HR = 6.27, p = 0.027) and a higher LN count (HR = 1.17, p = 0.028) were also linked to distant failure. Conclusions: Imaging-derived predictors including GTV, PNI, LN burden, and MRI-based response patterns demonstrate prognostic value for disease recurrence in NPC and may guide risk-adapted treatment strategies.

Objective: The infraorbital canal (IOC) houses critical structures like the infraorbital artery, vein, and nerve, and its atypical location within the maxillary sinus could pose risks during surgical procedures, making it crucial to understand its prevalence and distribution. The study aims to investigate the localization and frequency of the IOC within the maxillary sinus. Methods: This retrospective study analyzed computed tomography (CT) images from 1000 randomly selected patients (500 males, 500 females) aged 18 to 65 years who underwent paranasal region imaging at Istanbul Medipol University Medipol Mega University Hospital between 2015 and 2020. Exclusion criteria included major pathologies, prior surgeries, and poor image quality. The study focused on evaluating the localization of the IOC and its presence within the maxillary sinus, using coronal CT sections. Results: The IOC was found within the maxillary sinus in 8% of cases (44 males, 36 females). This variation was bilateral in 34 cases and unilateral in 46 cases, with no statistically significant relationship between sex and the occurrence or type of variation. The study’s findings align with previous research, which reported similar prevalence rates for this anatomical variation. Conclusion: The study confirms that the IOC is located within the maxillary sinus in a significant percentage of cases, emphasizing the importance of preoperative CT evaluation to prevent potential complications during maxillary sinus surgeries. These findings highlight the clinical relevance of considering individual anatomical differences in the localization of the IOC.

Background The aim of this study was to investigate the protective effect of thymoquinone, an antioxidant, on hearing loss induced by acoustic trauma in rats. Material and methods This study included 32 Wistar Albino rats divided into four groups: control, acoustic trauma, thymoquinone + acoustic trauma, and thymoquinone only, with eight rats per group. The control group received 0.5 mL of corn oil intraperitoneally for 10 days. The acoustic trauma group was exposed to 100 dB white noise at 4 kHz for 16 hours. The thymoquinone + acoustic trauma group received thymoquinone (10 mg/kg) intraperitoneally for two days before acoustic trauma and eight days after acoustic trauma. The thymoquinone only group received thymoquinone (10 mg/kg) for 10 days. Distortion product otoacoustic emissions (DPOAEs) were measured before and after treatments on days 1, 4, and 10. Results In the control group, DPOAE measurements showed no significant change over the study period. The acoustic trauma group exhibited a significant decrease in DPOAE on the first day after trauma, followed by some recovery. The thymoquinone + acoustic trauma group showed no significant decrease in DPOAE on the first day post-trauma, suggesting a protective effect. The thymoquinone only group also indicated no significant change in DPOAE measurements, suggesting that thymoquinone alone did not affect hearing function. Conclusion Thymoquinone demonstrated a protective effect against acoustic trauma-induced hearing loss in rats, as evidenced by stable DPOAE measurements post-trauma. These findings suggest that thymoquinone may help preserve hearing function by reducing oxidative stress in the cochlea. Further studies are needed to confirm these results in humans and optimize dosage and treatment protocols.

Otoplasti Burak ERKMEN Septoplasti Şamil ŞAHIN Uyku ve Üst Solunum Sistemi Lütfü ŞENELDİR Eğri Buruna Yaklaşım Emrah KINAL Temel Endoskopik Sinüs Cerrahisi Tarık Can ÖZEL Sinem ÖZCAN Gizem ÖZCAN Temporal İşitsel İşlemleme Ve İşitme Kaybı Merve Torun TOPÇU Vestibüler Sistem Anatomisi Özlem ERTUĞRUL Pediatrik Trakeotomi Yaşar Kemal DUYMAZ Meniere Hastalığı Mustafa Said TEKİN Alt Konkaların Cerrahi Yönetimi Tolga ÇİÇEK

Background: Body position and anesthesia may alter nasal anthropometric measurements, potentially affecting both preoperative assessment and intraoperative decisions in rhinoplasty. Quantifying these effects is essential for the accurate evaluation of nasal morphology. Methods: Thirty-five patients (28 females, 7 males; mean age 27.9 ± 6.95 years) undergoing primary rhinoplasty were prospectively included. Standardized lateral photographs were obtained in three conditions: upright, preanesthetic supine, and postanesthetic supine. Linear distances were measured using a digital caliper in a position replicating the photographic setup, and angular parameters were calculated from the photographs using ImageJ software (version 1.53, National Institutes of Health, Bethesda, MD, USA). Statistical analyses were performed to compare nasal measurements among the three positions. Results: The nasion–pronasale distance increased in the preanesthetic supine compared with the upright position (p < 0.001), while the pronasale–alar curvature distance remained unchanged (p = 0.984). The nasofrontal angle was higher upright (p < 0.001), whereas the nasolabial (p < 0.001) and nasomental (p = 0.010) angles were greater in the preanesthetic supine position. After anesthesia, both nasion–pronasale (p < 0.001) and pronasale–alar curvature (p = 0.001) distances increased further, while the nasofrontal angle remained higher upright (p < 0.001). Conclusions: Supine positioning and anesthesia significantly modify nasal profile parameters. Awareness of these predictable morphologic changes can help surgeons avoid misinterpretation and improve the accuracy of preoperative planning, intraoperative evaluation, and postoperative assessment.