Background: Ehrlich ascites carcinoma (EAC) is an undifferentiated carcinoma of the breast that was initially hyperdiploid, 100% malignantand had a short life span. It also had a high transplantability rate, no recurrence and rapid dissemination. Methods: Therefore, our study designed to assess the potential ameliorative ability of Chia (Salvia hispanica) seeds extract (CSE) on Ehrlich ascites carcinoma (EAC) induced kidney toxicity and tissue damage in mice. Forty female Swiss albino mice in all were split equally into four teams (Gp1, control; Gp2, CSE; Gp3, EAC; Gp4, EAC+CSE). Result: Current results revealed that; EAC induced elevated in the levels of serum urea, creatinine, potassium ions, chloride ions, renal tissue injury and a significant depletion in serum sodium ions, calcium ions as compared to normal control. In addition to EAC induced variable pathological changes in glomeruli and renal tubules as a marked renal damage, marked degeneration in renal tissues, moderate glomerular atrophyand marked cellular infiltration. Treatment of EAC with CSE (EAC+CSE) improved kidney functions and structure against EAC; where depletion take place in the levels of serum urea, creatinine, potassium ions, chloride ions and elevation in the levels of sodium ions, calcium ions as compared to EAC. One may draw the conclusion that CSE Having the ability to protect the kidneys from EAC cells induced kidney toxicity.

Because the Ehrlich ascites carcinoma (EAC) model can accurately predict survival time and is successful in creating neoplastic cells, it is frequently employed in experimental cancer studies. The present work is designed to investigate the antitumoral properties and therapeutic potential of Chia (Salvia hispanica) seed extract (ChSE) in inhibition of EAC-induced liver toxicity and tissue injury. All of the Forty female Swiss albino mice were equally separated into four cohorts (Gp1, control group; Gp2, CHSE group; Gp3, EAC group; Gp4, EAC+ChSE). Current results revealed that; EAC caused a notable increase in serum Aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) activities, body weight, liver weight, liver injury, and a significant depletion in albumin and total proteins as in contrast to the control Gp. Post-treatment of EAC with CHSE (EAC+ChSE) induced a significant depletion in serum ALT, AST, ALP, body weight, liver weight, liver injury, and a notable rise in albumin and total proteins as compared to EAC. One may conclude that ChSE possesses the capacity for a liver protective effect against EAC cell-induced liver injury and signposts about the potential benefits of ChSE in the treatment of liver toxicity.

Background: Cancer is one of the most dangerous diseases of the twentieth century and the speed of its spread is horrific. It is characterized by cellular growth and invades all tissues of the body. In recent years, all countries of the world have turned to cancer research in order to identify new drugs to treat cancer from various sources , Cancer is the most common disease that causes death in the world and this is attributed to many pathological factors, such as reactive oxygen species, which contribute to the initiation, spread and development of cancer. Methods: Our current research aims to investigate the therapeutic role of essential oils (C.S.) against Ehrlich Tumor renal damage in Mice. The mice were divided into four group (Gp1, control group, Gp2, Essential oils (C.S) group, Gp3, EAC group, Gp4, EAC with Essential oils (C.S). Result: Results showed the Essential oils (C.S) in pretreated (G4) lead to an improvement in urea, creatinine levels when compared to the EAC group. Through our results, it was shown that treatment with essential oils (C.S.) improved the levels of urea and creatinine comparing to the Gp3. It was noted that treatment with essential oils (C.S.) improved kidney tissue and VEGF protein expression the Gp4 compared to the Gp3 Groups. It could be concluded that essential oils (C.S) has a possible benefit to the kidneys against EAC induce kidney Toxicity.

Background:. Silver oxide nanoparticles (AgNPs) have many uses as antiviral materials that cause diseases, and they are considered AgNPs to destroy bacteria, and they can also be considered as antidotes for many serious diseases such as cancer and viruses, on the creation and characterization of silver oxide nanoparticles (AgNPs) and investigate the impact of varying doses of AgNPs on the antioxidant defense system, as well as the histology and immunohistochemistry of male rats liver.Methods: There were fifty male rats (150–170 g) utilized. The animals were split up into five groups, each with ten rats. During a three-week period, the first group served as the control, while groups II, III, IV, and V received oral treatment with AgNPs at doses of 1/150 LD50, 1/100 LD50, 1/50 LD50, and 1/25 LD50 mg/kg BW/day. After the trial was over, liver and blood samples were taken to look at various factors.Results:Silver nanoparticles (AgNPs) was prepared and At different concentrations and used in laboratory animals and characterized using different instruments .treatment with Silver nanoparticles (AgNPs) different concentrations Changes in histopathology and immunohistochemistry were noted, confirming that biochemical disruptions were caused by to Silver nanoparticles (AgNPs) distinct amounts in the liver of rats. Conclusion :It is evident that Silver nanoparticles (AgNPs) Produced significant negative effects in rat liver tissue and p53 protein in a dose-dependent way.

Background: Polycythemia vera (PV) is a myeloproliferative neoplasm characterized by the overproduction of red blood cells. A key feature of PV is the dysregulation of cytokine networks, with elevated levels of various pro-inflammatory cytokines contributing to disease progression. The JAK2 mutation, a common genetic driver of PV, stimulates the production of these cytokines, leading to increased cell proliferation, inhibited apoptosis and inflammation. Estimation of IL-12 and IL-21 Level and study the correlation between of theses cytokine with JAK2 V617F and hematological parameters. Methods: This study investigated 60 patients diagnosed with polycythemia vera (PV) at the National Center of Hematology between January 2023 and July 2024. The patient group consisted of 33 females and 27 males, with ages ranging from 18 to 75 years. Detection JAK2 V617F using Poly chain reaction (PCR) as well as estimation of IL-12 and IL-21 by sandwich ELISA technique. Result: In this Study 31 of PV patients detected as JAK2 V 617F Negative while 29 patients were positive. Also, this study examined the role of IL-12 and IL-21 in polycythemia vera (PV). Patients with the JAK2 V617F mutation had significantly higher IL-12 levels, suggesting a strong association. However, no significant differences were found in IL-21 levels between groups. Additionally, WBC count and platelets count were positively correlated with IL-21.

Cancer is a terrible illness that has enormously detrimental effects on society, the economy, health care and personal lives. In 2012, there were around 14.1 million cancer cases diagnosed worldwide, with 52.5% of those instances occurring in men and 47.5% in women. By 2030, that number is predicted to increase to 21.7 million. In 2012, this illness was responsible for 8.2 million fatalities globally; by the end of 2030, that number is predicted to rise to 13.0 million. The purpose of our study was to evaluate the capability of Apis mellifera venom (A.M.) to reduce renal toxicity and tissue damage caused by Ehrlich ascites carcinoma (EAC) in mice. A total of forty female Swiss albino mice were divided evenly among four groups (G1, control, G2, A.M., G3, EAC, and G4, EAC + A.M.). The findings demonstrated that, in comparison to the EAC group, the addition of Apis mellifera venom in co-treated groups resulted in lower levels of alpha-fetoprotein (AFP), ANA, anti-dsDNA, AST, ALT, and ALP. Liver slices from EAC showed several histological alterations, including mild fibrosis, noticeable diffuse necrosis of the hepatic parenchyma, noticeable inflammatory cells, and clogged blood sinusoids. Conversely, liver sections of mice co-treated with EAC+Apis mellifera showed a modest improvement in hepatocytes.