Understanding factors associated with flood incidence could facilitate flood disaster control and management. This paper assesses flood susceptibility of Perlis, Malaysia for reducing and managing their impacts on people and the environment. The study used an integrated approach that combines geographic information system (GIS), analytic network process (ANP), and remote sensing (RS) derived variables for flood susceptibility assessment and mapping. Based on experts’ opinion solicited via ANP survey questionnaire, the ANP mathematical model was used to calculate the relative weights of the various flood influencing factors. The ArcGIS spatial analyst tools were used in generating flood susceptible zones. The study found zones that are very highly susceptible to flood (VHSF) and those highly susceptible to flood (HSF) covering 38.4% (30,924.6 ha) and 19.0% (15,341.1 ha) of the study area, respectively. The results were subjected to one-at-a-time (OAT) sensitivity analysis to verify their stability, where 6 out of the 22 flood scenarios correlated with the simulated spatial assessment of flood susceptibility. The findings were further validated using real-life flood incidences in the study area obtained from satellite images, which confirmed that most of the flooded areas were distributed over the VHSF and HSF zones. This integrated approach enables network model structuring, and reflects the interdependences among real-life flood influencing factors. This accurate identification of flood prone areas could serve as an early warning mechanism. The approach can be replicated in cities facing flood incidences in identifying areas susceptible to flooding for more effective flood disaster control.