Objective: To determine whether psychological resilience and achievement motivation are significant mediators in the relationship between creative anxiety and professional identity among master’s nursing students. Methods: A questionnaire survey was conducted with 366 master’s nursing students from four universities in Shaanxi Province. The survey used the General Information Questionnaire, Creative Anxiety Scale, Professional Identity Scale, Psychological Resilience Scale, and Achievement Motivation Scale. Pearson’s r was used to examine the relationships among the variables, and a structural equation model (SEM) was employed to clarify the mediating effects. Results: In this study, the mean scores of creative anxiety, professional identity, psychological resilience, and achievement motivation among 366 master’s nursing students were (12.92 ± 3.58), (48.47 ± 12.76), (28.32 ± 7.71), and (6.23 ± 1.83), respectively. Creative anxiety showed significant negative correlations with professional identity (r = − 0.668, P < 0.001), psychological resilience (r = − 0.537, P < 0.001), and achievement motivation (r = − 0.503, P < 0.001). Conversely, professional identity demonstrated positive correlations with both psychological resilience (r = 0.713, P < 0.001) and achievement motivation (r = 0.663, P < 0.001). Mediation analysis revealed that the total effect of creative anxiety on professional identity (β = −0.458) comprised a direct effect (β = −0.124) and an indirect effect mediated through psychological resilience and achievement motivation (β = −0.334). A significant serial mediation effect was observed (β = −0.092), with psychological resilience and achievement motivation serving as sequential mediators between creative anxiety and professional identity. This serial mediation accounted for 8.97% of the total effect, with a 95% confidence interval of (− 0.211 ~ − 0.009). Conclusion: There is a multiple mediation effect among creative anxiety, professional identity, psychological resilience, and achievement motivation among master’s nursing students. Creative anxiety is closely related to professional identity. Therefore, it is recommended that university administrators focus on enhancing the psychological resilience and achievement motivation of master’s nursing students to reduce their creative anxiety and improve their professional identity. Clinical trial number: Not applicable.

To control the spatial placement and organize micro/nanodroplets (NDs) has fundamental importance both in science and engineering. Cholesteric liquid crystal (CLC) droplets with topological diversity can offer many self-assembly modalities to arrange guest NDs in their spherical confinement; however, limited progress has been achieved due to difficulties of loading NDs into stabilized host droplets. Here, a laser injection technique is introduced, through which a controlled number of NDs were injected from a pre-selected location onto the surface of the host droplet. The sequentially injected NDs spontaneously drifted toward areas with topological defects and self-assembled along its geometry or local director field into a predefined shape. Within CLC droplets with different topological structures, guest NDs self-assembled near areas with defect points as twisting radial chains and quill-like assembly structures, and along defect lines as discrete beads and helical threads, respectively. The injection speed of the NDs, controlled by laser power, was found to play a key role in the assembly geometry of NDs as well as the internal structure of the CLC droplet processed. This study expands our abilities to precisely organize NDs in a spherical confinement and such droplet-based microsystems have potential applications for sensors, photonic devices, pharmaceuticals, and biotechnology.

Acute myeloid leukemia (AML) is the most prevalent type of hematopoietic malignancy. Despite recent therapeutic advancements, the high relapse rate associated with extramedullary involvement remains a challenging issue. Moreover, therapeutic targets that regulate the extramedullary infiltration of AML cells are still not fully elucidated. The Aryl Hydrocarbon Receptor (AHR) is known to influence the progression and migration of solid tumors; however, its role in AML is largely unknown. This study explored the roles of AHR in the invasion and migration of AML cells. We found that suppressed expression of AHR target genes correlated with an elevated relapse rate in AML. Treatment with an AHR agonist on patient-derived AML cells significantly decreased genes associated with leukocyte trans-endothelial migration, cell adhesion, and regulation of the actin cytoskeleton. These results were further confirmed in THP-1 and U937 AML cell lines using AHR agonists (TCDD and FICZ) and inhibitors (SR1 and CH-223191). Treatment with AHR agonists significantly reduced Matrigel invasion, while inhibitors enhanced it, regardless of the Matrigel’s stiffness. AHR agonists significantly reduced the migration rate and chemokinesis of both cell lines, but AHR inhibitors enhanced them. Finally, we found that the activity of AHR and the expression of NMIIA are negatively correlated. These findings suggest that AHR activity regulates the invasiveness and motility of AML cells, making AHR a potential therapeutic target for preventing extramedullary infiltration in AML.

Objective: To systematically analyze the current status of interventions for alleviating existential distress in hemodialysis patients, explore the core components, outcome measures, and effectiveness of these interventions, and provide a theoretical basis for developing interventions targeting existential distress in this population. Methods: Following the methodology of scoping reviews, eight databases—PubMed, SinoMed, CHINA, Embase, Web of Science, CNKI, Wanfang, and VIP were systematically searched using computerized methods. The search period spanned from database inception to July 1, 2025. Key information was extracted from the included studies, including publication year, intervention methods, intervention duration, and outcome measures. Results: A total of 15 studies were included. Interventions related to concepts of existential distress in hemodialysis patients primarily included cognitive-behavioral therapy, emotional release therapy, and relaxation training. These interventions demonstrated positive effects on psychological distress, psychological crisis, demoralization, and quality of life among hemodialysis patients. Conclusion: Currently, there are no intervention studies specifically targeting existential distress in hemodialysis patients. Healthcare professionals should, in the future, draw upon interventions related to existential distress concepts—such as those addressing demoralization and psychological crisis to develop tailored intervention programs for alleviating existential distress in hemodialysis patients.