Differentiating tuberculous spondylodiscitis (TS) from pyogenic spondylodiscitis (PS) is challenging due to overlapping clinical and radiological features.

Amaç: Sağlık çalışanları aşıyla önlenebilir hastalıklar için risk altında olan kişilerdir. Çalışmamızın amacı; bu kişilerde hepatit A ve B, kızamık, kızamıkçık, kabakulak ve suçiçeği virüslerine karşı bağışıklık durumlarını belirlemek, yaş ve cinsiyete göre değerlendirmektir. Gereç ve Yöntemler: Çalışmaya Kasım 2023- Mayıs 2024 tarihleri arasında Ankara Etlik Şehir Hastanesi Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji polikliniği’ne, aşıyla önlenebilen bulaşıcı hastalıkların taranması amacıyla başvuran, semptom tariflemeyen, 18 yaş üstü, 2409 sağlık çalışanı dahil edilmiştir. Bulgular: Anti HBs %74,17, anti HAV %31,48, kızamık IgG %64,36, kızamıkçık IgG %95,9, kabakulakIgG %72,22, su çiçeği IgG %86,28 pozitif bulunmuştur. HBsAg, anti HAV, kabakulak Ig G ve kızamık Ig G pozitif olanların yaş ortancası daha yüksek saptanmıştır (p

Objectives: Nitrosative stress is defined as a condition in which oxidative stress accompanies the presence of excess NO and they both may alter the integrity of the red blood cell membrane (RBC). In this study, age- and sex-related effects of nitrosative stress on the membrane osmotic fragility of RBC were investigated using NO and superoxide donors in the RBC isolated from participants. Methods: A total of 119 men and women volunteers, both young and old, provided blood samples for the study. The effects of NO precursor L-arginine, Nitric Oxide Synthase (NOS) inhibitor L-NMMA, long-acting NO donor Diethylenetriamine/NO (DETA10 ⁻⁶ –10 ⁻⁴ M), short-acting NO donor Diethylamine-NONOate (DEA10 ⁻⁶ –10 ⁻⁴ M) and superoxide donor pyrogallol (Pyr) on the fragility of RBC were studied using NaCl-induced osmotic hemolysis. Hemoglobin level, plasma total antioxidant capacity (TAC), and nitrite levels were measured by spectrophotometric methods. Results: Although the RBC hemolysis of all groups was not affected by L-arg and L-NMMA, the effect of DETA and DEA varied. The RBC fragility of old and young men was more sensitive to Pyr-induced oxidative stress than old and young women. Human RBC was differentially affected by nitrosative stress induced by Pyr10 ⁻³ M plus varying concentrations of DETA and DEA depending on age and sex. While the plasma TAC values of the young men were higher than those of young women, there was no significant difference in plasma nitrite levels between all groups. Conclusions: The findings of this study indicate that the fragility of human red blood cells (RBCs) in response to oxidative and nitrosative stress varies depending on sex and age.