In recent years, governments have promoted the shift to low-emission transport systems, with electric and hydrogen vehicles emerging as key alternatives for greener urban mobility. Evaluating zero- or near-zero tailpipe solutions requires a Lifecycle Assessment (LCA) approach, accounting for emissions from energy production, components and vehicle manufacturing. Such studies mainly address Greenhouse Gas (GHG) emissions, while other pollutants are often overlooked. This study compares the Human Toxicity Potential (HTP) of Battery Electric Vehicles (BEVs), Fuel Cell Vehicles (FCVs), Hydrogen Internal Combustion Engine Vehicles (H2ICEVs) and hybrid H2ICEVs for public transport in the European Union. Current and future scenarios (2024, 2030, 2050) are examined, considering evolving energy mixes and manufacturing impacts. Results underline that BEVs are characterized by the highest HTP in 2024, and that this trend is maintained even in future scenarios. As for hydrogen-based powertrains, they show lower HTPs, similar among them. This work underlines that current efforts must be intensified, especially for BEVs, to further limit harmful emissions from the mobility sector.