Can skyscrapers survive after COVID-19? Can the idea of integrating vertical farming (VF) into vertical architecture support the environmental, economic, and social issues in the post-pandemic era? Answering these questions is the main objective of this study. Therefore, it explores a) the impact of the pandemic on the built environment, especially skyscrapers; b) the challenges facing the survival of skyscrapers; c) the design parameters and main components of VF; and d) the expected feasibility of integrating VF into vertical architecture to reduce the effects of the pandemic. The research concludes that the skyscraper-integrated vertical farming (SIVF) paradigm can create a closed ecosystem that preserves the environment by a) supporting food security, b) improving indoor environmental quality, c) enhancing psychological and physical health, d) saving energy, e) reducing greenhouse gas emissions and releasing oxygen, and f) supporting the local economy. Consequently, the SIVF paradigm can inaugurate an innovative approach that provides insights into new research trends and discoveries. However, further constraints in the adoption of SIVF should be addressed, and collaborations between researchers and multidisciplinary experts must be created to achieve suitable solutions. GRAPHICAL ABSTRACT