Background/Objectives: Generalized anxiety disorder (GAD) is one of the most commonly diagnosed anxiety disorders in primary care. The global lifetime prevalence of GAD is estimated at 3.7%, ranging from 1.6% in low-income countries to 5.0% in high-income countries, underscoring its widespread impact. Given the frequent co-occurrence of GAD with obesity, this association has important clinical implications, particularly for screening, prevention, and treatment strategies. The aim of this review is to identify potential biological mechanisms linking obesity and GAD, summarize the current state of knowledge in this area, and highlight existing research gaps, as well as directions for future research. Methods: This narrative review is based on the literature published between 2015 and 2025 concerning the co-occurrence of GAD and obesity, with a focus on potential shared mechanisms including HPA axis dysregulation, chronic inflammation, oxidative stress, insulin resistance, gut–brain axis and microbiota dysbiosis, sleep disturbance, and maladaptive eating behaviors. Results/Conclusions: A growing body of evidence suggests an important, albeit still ambiguously defined, relationship between obesity and GAD. GAD and obesity may reinforce each other, leading to a mutually reinforcing relationship. Despite growing interest, high-quality prospective and interventional studies focusing specifically on GAD are lacking. A potentially effective therapeutic approach should be integrated and multidisciplinary, combining psychological, pharmacological, and lifestyle interventions. It may also be beneficial for clinicians to consider routine assessment of anxiety in patients with obesity and, conversely, to monitor metabolic risk in individuals with GAD. Such an approach, targeting both mental and metabolic domains, holds promise for improving outcomes.

Adolescents across the globe experience increasing demands for care, and the mental health of Polish and Ukrainian youth is especially concerning, due to ongoing war and displacement. This study explores the acceptability, feasibility, and short‐term effects of a digital, self‐guided single‐session intervention (SSI) for improving the mental health of Polish and Ukrainian youth, including Ukrainian refugees in Poland. A non‐randomized, open pilot trial was conducted from March to June 2024, involving youth aged 10–18 years from Poland and Ukraine. Participants completed an SSI after cultural adaptations and translation into Polish and Ukrainian. Measures assessed hopelessness, self‐hate, agency, perceived control, and acceptability. Statistical analyses included paired t‐tests and effect size calculations to examine intervention effects. Among 176 Polish and 139 Ukrainian youth who began the intervention, completion rates were 80.7% and 62.6%, respectively. Polish participants exhibited significant improvements in hopelessness, self‐hate, perceived control, and agency, while Ukrainian youth showed moderate improvements in perceived control but limited change in other mental health indicators. Acceptability ratings were high across all youth. Findings suggest SSIs hold potential as a scalable option for mental health care. However, the varied outcomes across the two groups highlight the need for further refinement, especially for displaced youth.