Aims: Cancer and its treatment are often accompanied by psychological symptoms; this highlights the importance of psycho-oncological care. This study aimed to investigate the psychological symptoms and psycho-oncological awareness of cancer patients following a major earthquake. Methods: This single-center, cross-sectional study used prospective participant recruitment between July 1, 2026, and August 1, 2026. A total of 78 cancer patients aged 18 and older were included in the study, and they were administered a questionnaire and the Symptom Checklist-90-Revised (SCL-90-R). Results: Most participants were female, married, with children, unemployed, primary school graduates, and residents of the urban center. More than 20% of cancer patients were found to have high scores on subscales measuring depressive symptoms, additional items, obsessive-compulsive, and somatization symptoms. While 15.38% of participants indicated that they had heard of the term “psycho-oncology” before, 8.97% stated that they were knowledgeable about psycho-oncology. 14.10% of participants also stated that they received psychological support during the course of their illness. Higher psychological symptom scores were observed among participants reporting weight loss, pain, female gender, urban residence, lack of knowledge about the illness and the belief that the earthquake had caused their illness. Conclusion: In conclusion, the findings indicate a significant burden of psychological symptoms among cancer patients receiving treatment at an oncology center established after the February 6 earthquake, while also revealing that awareness of psycho-oncological services remains limited. Routine psychological assessment should be integrated into oncological care, and supportive interventions should be tailored to patients’ demographic, clinical, and psychosocial characteristics. Further multicenter studies with larger samples and more comprehensive assessments of earthquake-related experiences, psycho-oncological awareness, and access to psycho-oncological services are needed to better characterize psychological symptoms in oncology populations in post-disaster environments.

Çocukluk Çağı Otizm Spektrum Bozukluğu Tedavisinde Güncel Yaklaşımlar Bari AY Deprem Afeti Sonrası Ruh Sağlığı Şeyma SEHLİKOĞLU Travmanın Nörobiyolojisi Melike KARA TÜZÜN Bipolar Afektif Bozukluk Etyopatogenezinde Genetik, Nöroendokrin ve Nörokimyasal Faktörlerin İncelenmesi Oğuzhan TÜZÜN Askeri Muayene Uygulamaları Fatih SAĞLAM Psikobiyotikler ve Şizofreni Derya CANLI Psikiyatrik Acil Hastalarda Acil Serviste Hasta ve Yakınları ile İletişim Meltem GÜRÜ Çocuk ve Ergenlerde İrritabilite ve Agresyon Onat YETİM Lut TAMAM

Background: Diabetes mellitus (DM) management is influenced by both physiological and psychosocial factors. Personality traits and psychiatric symptoms may affect glycemic control, but their exact relationship remains unclear. This study aimed to evaluate the association between glycemic control, personality traits, and psychological symptoms such as depression, anxiety, and stress in patients with DM. Methods: A total of 174 adult patients with Type 2 DM (T2DM) were included. Glycemic control was assessed via HbA1c values over one and five years. Personality traits were measured using the Personality Belief Questionnaire-Short Form (PBQ-SF), and psychiatric symptoms were evaluated with the Symptom Checklist-90-Revised (SCL-90-R). Patients were grouped based on HbA1c levels: good (9%) control. Results: Significant differences were found in several personality traits, including obsessive-compulsive, histrionic, paranoid, passive-aggressive, antisocial, and schizoid traits, between groups, with higher scores in patients with moderate glycemic control compared to those with poor control. No significant relationship was observed between psychiatric symptoms and glycemic control. The proportion of patients meeting the predefined HbA1c follow-up frequency threshold was lowest in the poor control group. Conclusions: General psychiatric symptoms did not show significant differences across glycemic control groups. Several maladaptive personality traits differed between groups in univariate analyses; however, after adjustment for potential confounders, only passive-aggressive personality traits remained independently associated with HbA1c levels. These findings indicate a possible association between specific personality characteristics and glycemic control, although no direct clinical utility can be inferred from the present data. Further longitudinal studies are required to clarify these relationships.

Anksiyolitik, sedatif ve hipnotik ilaçlar, temel olarak beyindeki ana inhibitör nörotransmitter olan Gama Amino Bütirik Asit (GABA) sistemi üzerinden veya adrenerjik, serotonerjik ve melatoninerjik yolaklar aracılığıyla etki göstererek kaygı bozuklukları ve uykusuzluk tedavisinde yaygın olarak kullanılan ajanlardır. Bu ilaç gruplarının en sık reçete edilenleri arasında yer alan benzodiazepinler; kaygı giderici, kas gevşetici ve antikonvulzan etkilere sahip olmakla birlikte uyuşukluk, amnezi, paradoksik taşkınlık gibi belirgin yan etkilere yol açabilir; uzun süreli kullanımlarında ise tolerans, yoksunluk semptomları ve bağımlılık riski taşırlar. Benzodiazepin dışı birer alternatif olan Z-ilaçları ve melatonin reseptör agonistleri daha çok hipnotik etkileriyle uyku bozukluklarında tercih edilirken; buspiron bağımlılık riski olmaksızın yaygın anksiyete bozukluğunda, beta blokerler ise anksiyetenin otonomik hiperaktivitesini baskılamada kullanılır. Birinci jenerasyon antihistaminikler sedatif özellikleri nedeniyle sakinleştirici olarak, kalsiyum kanallarına bağlanan GABA analogları (pregabalin ve gabapentin) ise özellikle dirençli kaygı durumlarında endikasyon dışı tedavi olarak öne çıkmaktadır. Güncel klinik araştırmalar, geleneksel sistemlerin ötesine geçerek glutamat, nöropeptit, nörosteroid yolakları ve ketamin gibi yeni farmakoterapiler üzerine yoğunlaşmaktadır. Anxiolytic, sedative, and hypnotic drugs are agents widely used in the treatment of anxiety disorders and insomnia, primarily acting through the Gamma-Aminobutyric Acid (GABA) system, which is the main inhibitory neurotransmitter in the brain, or via adrenergic, serotonergic, and melatoninergic pathways. Benzodiazepines, which are among the most frequently prescribed of these drug groups, possess anxiolytic, muscle relaxant, and anticonvulsant effects; however, they can lead to prominent side effects such as drowsiness, amnesia, and paradoxical disinhibition, and they carry risks of tolerance, withdrawal symptoms, and dependence during long-term use. While Z-drugs and melatonin receptor agonists, which are non-benzodiazepine alternatives, are preferred in sleep disorders chiefly for their hypnotic effects; buspirone is used in generalized anxiety disorder without the risk of dependence, and beta-blockers are utilized to suppress the autonomic hyperactivity of anxiety. First-generation antihistamines are employed as sedatives due to their calming properties, whereas GABA analogs (pregabalin and gabapentin) that bind to calcium channels stand out as off-label treatments, particularly in refractory anxiety conditions. Current clinical research shifts beyond traditional systems, focusing on novel pharmacotherapies including glutamate, neuropeptide, and neurosteroid pathways, as well as ketamine.

Background: The relationship between psychological factors and asthma has received attention since very early times. However, there’s a lack of knowledge about the temperament and character features of asthma patients. We aimed to assess if there are specific personality traits in asthma patients.Methods: Thirty-eight patients with asthma and thirty-five healthy individuals were enrolled in the study. The sociodemographic data form and Temperament and Character Inventory (TCI) and Toronto Alexithymia Scale (TAS) were applied to all participants. Results: The mean age was 40.9 ± 15.9 in the asthma group (52.1%) and 37.3 ± 14.3 in the control group (47.9%). There were 29 females and 9 males in asthma group, 19 females and 16 males in control group. In analysis of temperament and character subscales, the scores of harm avoidance, frugality, sentimentality and transpersonal identification were higher in asthma patients than the control group; the differences were statistically significant (p0.05).Conclusions: Our study showed that there were character and temperament differences between asthma patients and healthy group. There were no differences for alexithymia between the groups. Further studies are needed to evaluate the causes of differences and the impacts of traits on disease course.

Background: Substance use disorder (SUD) is associated with systemic inflammatory activation and may influence hematological and coagulation-related pathways. Chronic exposure to psychoactive substances may promote immune activation, endothelial dysfunction, and increased platelet reactivity, thereby contributing to inflammation–coagulation crosstalk. Routine laboratory markers derived from complete blood count and coagulation tests have recently gained attention as potential indicators of these biological alterations. Objective: This study aimed to evaluate hematological inflammatory indices, platelet-related parameters, and coagulation markers in individuals with SUD compared with healthy controls. Methods: This cross-sectional study included individuals diagnosed with SUD (n = 55) and age- and sex-matched healthy controls (n = 40). Hematological parameters, including neutrophil, lymphocyte, monocyte, platelet indices, and derived inflammatory ratios, were analyzed. Coagulation parameters, including prothrombin time (PT), activated partial thromboplastin time (aPTT), international normalized ratio (INR), fibrinogen, and D-dimer levels, were also evaluated. Statistical analyses were performed to compare laboratory findings between groups. Results: Significant alterations were observed in several hematological and fibrinolytic parameters in individuals with SUD. Specifically, the neutrophil-to-lymphocyte ratio (NLR), platelet count (PLT), and D-dimer levels were significantly higher in the study group compared with the controls, suggesting increased inflammatory activity, platelet activation, and fibrinolysis. In contrast, the fibrinogen levels did not show clinically meaningful differences between the groups. Conclusions: Individuals with SUD exhibit alterations in hematological inflammatory indices, platelet-related parameters, and fibrinolytic markers. Routine hematological and coagulation parameters may provide accessible indicators of systemic inflammatory and hemostatic disturbances associated with SUD and may support future research aimed at identifying potential biological markers of addiction.