The unmet need for mental health care is a global concern. There is a lack of cross-cultural studies examining adolescent help-seeking behavior from both formal and informal sources, including both high-and lower-income countries. This study investigates mental health help-seeking behavior in eight Asian and European countries. Data from 13,184 adolescents aged 13–15 (51% girls) was analysed using mixed-effects logistic regression with school-wise random intercepts to compare countries and genders. Although a significant proportion of adolescents considered getting or sought informal help, formal help-seeking remained exceptionally low, especially in middle-income countries (< 1%), while it ranged from 2 to 7% in high-income countries. Among adolescents with high emotional and behavioral problems (scoring above the 90th percentile on the Strengths and Difficulties Questionnaire), 1–2% of those in middle-income countries and 6–25% of those in high-income countries sought formal help. Girls generally seek more help than boys. The study shows the most adolescents do not receive formal help for mental health problems. The unmet need gap is enormous, especially in lower-income countries. Informal sources of support, including relatives, peers, and teachers, play a crucial role, especially in lower-income countries.

Prenatal exposure to vitamin D may play a significant role in human brain development and function. Previous epidemiological studies investigating the associations between maternal vitamin D status and offspring developmental and psychiatric outcomes in humans have been inconclusive. We aimed to systematically assess the results of previously published studies that examined the associations between maternal vitamin D levels, measured as circulating 25(OH)D levels in pregnancy or at birth, and offspring neuropsychiatric and psychiatric outcomes. Systematic searches were conducted using MEDLINE, Embase, PsychINFO and Web of Science for studies published by 10 August 2022. We included human observational studies that examined associations between prenatal or perinatal vitamin D levels and offspring neuropsychiatric and psychiatric outcomes and were published in English in peer-reviewed journals. Of the 3729 studies identified, 66 studies were screened for full texts and 29 studies published between 2003 and 2022 were included in the final review. There was a small amount of evidence for the association between prenatal vitamin D deficiency and autism spectrum disorder. When studies with larger sample sizes and stricter definitions of vitamin D deficiency were considered, positive associations were also found for attention-deficit/hyperactivity disorder and schizophrenia. Future studies with larger sample sizes, longer follow-up periods and prenatal vitamin D assessed at multiple time points are needed.

Background: There has been a lack of research about the time trends and socio-demographic risk factors for children and adolescents who receive treatment for anxiety disorders. This study aimed to fill these gaps in our knowledge by examining a nationwide sample of Finnish children and adolescents diagnosed in specialized healthcare settings. Methods: This study comprised national register data of all singleton children born in Finland from 1992–2006 who were diagnosed with anxiety disorders from 1998–2012. The changes in time trends in incidence were studied by dividing the study sample into three cohorts by birth years: 1992–1996, 1997–2001 and 2002–2006, who were followed up until the age of 20, 15 and 10 years, respectively. The 22,388 individuals with anxiety disorders were age and gender matched with 76,139 controls from the general population. Logistic regression was used to examine the socio-demographic risk factors and anxiety disorders in the entire sample. Comorbid disorders were examined in the oldest birth cohort (1992–1996 born). Results: Comparing the 1992–1996 and 2002–2006 cohorts showed that the cumulative incidence of treated anxiety disorders at the age of 10 increased from 0.3 to 1.2% among females and 0.46 to 1.9% among males. Subjects had higher likelihood for being diagnosed with an anxiety disorder if their mothers had low maternal socio-economic status class at birth (OR 1.53, 95% CI 1.45–1.61) compared to higher SES class, and marital status was single at the time of birth (OR 2.02, 95% CI 1.87–2.17) compared to married or in a relationship. They had lower risk of anxiety disorders diagnosis if born in rural (OR 0.82, 95% CI 0.79–0.86) or semi-urban areas (OR 0.79, 95% CI 0.76–0.82) when compared to urban residence. There was a wide range of psychiatric comorbidities, and unipolar depression was the most common (31.2%). Conclusion: Anxiety disorders diagnosed by specialized Finnish services increased from 1998–2012 in both genders. This could indicate a real increase in overall anxiety disorders or an increase in treatment seeking. The findings on maternal socioeconomic status and single parenting improve the recognition of the environmental risk factors for anxiety disorders among children and adolescents.

Introduction: Emotional awareness and emotion regulation are crucial for cognitive and socio-emotional development in children. School-based interventions on socio-emotional skills have the potential to prevent these problems and promote well-being of children. The Japanese school-based program, Universal Unified Prevention Program for Diverse Disorders (Up2-D2), has shown preventive effects on mental health of children in Japan. The aims of this protocol paper are to describe the unique process of adapting the Up2-D2 from Eastern to Western context, and to present a feasibility study of the intervention, conducted in Finland.Methods: The cultural adaptation process started with the linguistic translation of materials, followed by the modification of language to fit the Finnish context. While the Japanese ideology was saved, some content was adapted to fit Finnish school children. Further modifications were made based on feedback from pupils and teachers. The Finnish version of the program was named “Let’s learn about emotions” and consisted of 12 sessions and targeted 8- to 12-year-old pupils. A teacher education plan was established to assist Finnish teachers with the intervention, including a workshop, teachers’ manual, brief introductory videos, and online support sessions. A feasibility study involving 512 4th graders in the City of Hyvinkää, South of Finland, was conducted. It assessed emotional and behavioral problems, classroom climate, bullying, loneliness, perception of school environment, knowledge of emotional awareness, and program acceptability.Discussion: The originality of this study underlies in the East–West adaptation of a cognitive behavioral therapy-based program. If promising feasibility findings are replicated in Finland, it could pave the way for further research on implementing such programs in diverse contexts and cultures, promoting coping skills, awareness, social skills and early prevention of child mental health problems.Ethics: The ethical board of the University of Turku gave ethics approval for this research. The educational board of the City of Hyvinkää accepted this study.

No previous studies have evaluated the efficacy of internet-based cognitive-behavioral therapy (ICBT) among children below age 13 years screened at the population level. This study was an open, 2 parallel-group randomized controlled trial (RCT), stratified by sex, that compared ICBT with telephone coaching vs an educational control. Altogether 465 children (mean age = 11.5 years, SD = 1.0 years, 71.4% girls) were randomly allocated to ICBT or psychoeducation. The 10-week ICBT included weekly digital material and exercises and weekly telephone calls. Assessments comprised child and parent reports on anxiety (Screen for Child Anxiety Related Emotional Disorders questionnaire [SCARED]), impacts of anxiety, quality of life, comorbidity, and parental mental health assessed at baseline and at 6-month follow-up. The ICBT group yielded significantly higher improvement in primary outcomes (SCARED total scores) when compared with control group in the child reports (p = .04, Cohen d = 0.17) but not in the parent reports (p = .41, d = 0.03). The ICBT group had significantly higher improvement in several secondary measures of outcome, including child-reported SCARED generalized anxiety (p = .047, d = 0.09), separation anxiety (p = .004, d = 0.40), social anxiety (p = .007, d = 0.27), the parent-reported Strengths and Difficulties Questionnaire total score (p = .002, d = 0.22), emotional difficulties (p = .02, d = 0.20), hyperactivity (p = .003, d = 0.19), and quality of life (p = .02, d = 0.16). When children were screened at the population level for anxiety and enrolled in this RCT study of ICBT combined with telephone guidance, they showed efficacy in improving anxiety and quality of life. These findings are encouraging when developing early population-based intervention strategies for childhood anxiety. This randomized controlled trial compared internet-based cognitive-behavioral therapy (ICBT) with telephone coaching to an internet-based educational control (EC) among 10- to 13-year-old children (n = 465) screened for anxiety at a population level in school health care check-ups. Both ICBT and EC groups showed significant improvement in the parent and child reports between baseline and follow-up in most measures related to child anxiety, other psychopathology, daily functioning level, and quality of life, as well as parental emotional well-being. The ICBT group showed significantly better improvement when compared with the EC group in child-reported anxiety as well as on parent-reported and child-reported overall psychopathology, emotional difficulties, hyperactivity, and quality of life. Overall, the effect sizes for these relative improvements at follow-up were small. A Randomized Controlled Study of Digitalized Cognitive-behavioral Intervention for Childhood Anxiety; https://clinicaltrials.gov/study/NCT03310489.