Hyungmin Kim, Jeehan Lee, Soon-Young Jung, Hye Hyeon Yun, Jeong-Heon Ko, and Jeong-Hwa Lee. Mol. Cells 2022;45:718-28. https://doi.org/10.14348/molcells.2022.0037

Data mining plays a critical role in sustainable decision-making. Although the k-prototypes algorithm is one of the best-known algorithms for clustering both numeric and categorical data, clustering a large number of spatial objects with mixed numeric and categorical attributes is still inefficient due to complexity. In this paper, we propose an efficient grid-based k-prototypes algorithm, GK-prototypes, which achieves high performance for clustering spatial objects. The first proposed algorithm utilizes both maximum and minimum distance between cluster centers and a cell, which can reduce unnecessary distance calculation. The second proposed algorithm as an extension of the first proposed algorithm, utilizes spatial dependence; spatial data tends to be similar to objects that are close. Each cell has a bitmap index which stores the categorical values of all objects within the same cell for each attribute. This bitmap index can improve performance if the categorical data is skewed. Experimental results show that the proposed algorithms can achieve better performance than the existing pruning techniques of the k-prototypes algorithm.

Procyanidolic oligomers (leucocyanidines, LCs) extracted from grape seeds (Vitis vinifera) are known to have antioxidant and antimutagenic activities, and a protective effect against cardiovascular disease. In the present study we examined the influence of LCs on the activities of phase 1 enzymes and conjugation enzymes and on antioxidant enzymes such as superoxide dismutase, catalase, and glutathione peroxidase. Administration of LCs (25, 50, and 100 mg/kg. p.o. for 7 d) markedly decreased the activities of NADPH-cytochrome P450 reductase, P4501A1, P4501A2, and P4503A4, but significantly increased the activities of glutathione S-transferase and phenolsulfotransferase in rat liver. However, the activities of antioxidant enzymes were not affected by LC administration. The inhibition of P450s and increases in phase II enzyme activities indicate a role for LCs as a chemopreventive agent against toxic or carcinogenic metabolites of P450 isozymes.