Pseudomonas aeruginosa and Staphylococcus aureus are highly resistant microorganisms that contribute to prolonged hospital stays and increased mortality. Developing new antimicrobial agents is essential to address this global health challenge. Nanoemulsions (NE) containing essential oils (EOs) and phenolic compounds with antimicrobial activity represent a promising alternative. This study reports, for the first time, the formulation of a NE containing Cymbopogon flexuosus and eugenol (NECE) and its antimicrobial activity against P. aeruginosa and S. aureus. NECE exhibited suitable physicochemical properties (mean size < 200 nm, PDI < 0.3, and negative zeta potential) and remained stable for 90 days at 4 °C while maintaining antimicrobial activity. It showed bactericidal effects at 2.5 mg/mL against P. aeruginosa and 0.625 mg/mL against S. aureus. Moreover, NECE improved the biocompatibility of the free oil (FO) in Peripheral Blood Mononuclear Cells (PBMCs). Altogether, these findings demonstrate, for the first time, that NECE is a stable nanoemulsion with enhanced antimicrobial activity and biocompatibility, supporting its potential as a safe and effective topical strategy against wound-associated pathogens.

Silver is a metal known for its antimicrobial and antibacterial properties, and when reduced to the nanoparticle scale, there is an increase in its surface area, which enhances these properties. As a result, silver nanoparticles have been widely studied and used in wound treatment, especially in cases of chronic infections and infected wounds, such as those found in people with diabetes. The purpose of this study was to provide an updated overview of the potential of silver nanoparticles and their applications in diabetic wound treatment. A search was conducted in the PubMed Database, ranging over the last five years, using the descriptors and Boolean markers: silver nanoparticles AND wound healing AND diabetes. The search resulted in 54 articles, of which 14 were selected to compose this review according to the proposed criteria. From the studies included in this review, it was possible to observe that among many nanostructures containing AgNPs, hydrogel and spray were the most used for topical application in vivo. Of the analyzed articles, AgNPs showed promising results for the healing of diabetic wounds, showing anti-inflammatory and antibacterial properties

Essential oils are compounds of natural origin with numerous therapeutic properties, however, there are limitations regarding their stability, being easily degraded by processes of oxidation, volatilization, heating and light, characteristics that can be overcame with the use of nanotechnology. The aim of this study was to investigate the main types of nanocarriers used to carry essential oils and to assess their healing potential. A research was carried out in the Web of Science database, without a time limit, using the Boolean descriptors and markers: nano* AND essential oils AND wound healing. Articles published in Portuguese and English, with free access to the full article on the online platform, were included in the review. The research resulted in 168 articles, of which 22 were selected to include this review according to the proposed criteria. From the studies included in this review, it was possible to observe that nanocarriers such as nanoemulsions and nanofibers were able to activate the functionality of essential oils effectively and safely, achieving success in healing and antibacterial activity, demonstrating that nanotechnology is a promising alternative to develop nanotechnology-based formulations containing essential oils for wound healing.

Chalcones are α,β‐unsaturated ketones with extended π‐conjugation, making them promising scaffolds for the development of organic UV filters. In this study, a series of substituted chalcones inspired by the chemical structure of avobenzone (AVO) was synthesized and systematically evaluated for UV absorption profiles, photostability, antioxidant potential, photoprotection, and safety‐related properties. Among the compounds, the 2‐hydroxychalcones 3ca and 3cb showed the most promising profiles. Chalcone 3ca exhibited λ _max at 365 nm, critical wavelength of 386 nm, UVA/UVB ratio of 6.3, and molar absorptivity of 58,880 M ⁻¹ cm ⁻¹ , whereas 3cb showed λ _max at 353 nm, critical wavelength of 376 nm, UVA/UVB ratio of 3.2, and molar absorptivity of 28,900 M ⁻¹ cm ⁻¹ . Both compounds fulfilled broad‐spectrum protection criteria and showed <5% degradation after UVA and UVB irradiation, with photostability comparable to benzophenone‐3 and superior to AVO. Formulations containing 3ca and 3cb reduced UVA‐induced DNA damage by 90.4% and 95.1%, respectively. Skin permeation studies demonstrated predominant retention in the stratum corneum (94.1% for 3ca and 97.4% for 3cb ), minimal penetration into viable epidermis and dermis, and no detectable compound in receptor fluid. Both chalcones showed no relevant irritation in the HET–CAM assay and no significant alterations in skin biometric parameters after topical application. Collectively, these findings support the potential of hydroxy‐substituted chalcones as photostable broad‐spectrum UV filters for topical application.