Ziyang green tea was considered a medicine food homology plant to improve chronic fatigue Ssyndrome (CFS) in China. The aim of this research was to study the therapeutic effect of selenium-polysaccharides (Se-TP) from Ziyang green tea on CFS and explore its metabolic mechanism. A CFS-rats model was established in the present research and Se-TP was administrated to evaluate the therapeutic effect on CFS. Some serum metabolites including blood urea nitrogen (BUN), blood lactate acid (BLA), corticosterone (CORT), and aldosterone (ALD) were checked. Urine metabolites were analyzed via gas chromatography-mass spectrometry (GC-MS). Multivariate statistical analysis was also used to check the data. The results selected biomarkers that were entered into the MetPA database to analyze their corresponding metabolic pathways. The results demonstrated that Se-TP markedly improved the level of BUN and CORT in CFS rats. A total of eight differential metabolites were detected in GC-MS analysis, which were benzoic acid, itaconic acid, glutaric acid, 4-acetamidobutyric acid, creatine, 2-hydroxy-3-isopropylbutanedioic acid, l-dopa, and 21-hydroxypregnenolone. These differential metabolites were entered into the MetPA database to search for the corresponding metabolic pathways and three related metabolic pathways were screened out. The first pathway was steroid hormone biosynthesis. The second was tyrosine metabolism, and the third was arginine-proline metabolism. The 21-hydroxypregnenolone level of rats in the CFS group markedly increased after the Se-TP administration. In conclusion, Se-TP treatments on CFS rats improved their condition. Its metabolic mechanism was closely related to that which regulates the steroid hormone biosynthesis.

Background: While frailty poses significant challenges in aging populations, evidence regarding gut microbiome-targeted nutritional strategies remains limited. The novel Dietary Index for Gut Microbiota (DI-GM), quantifying microbial-pertinent dietary patterns, provides a framework for personalized frailty mitigation.Methods: This cross-sectional study analyzed 12,914 middle-aged and older Americans (≥45 years) from National Health and Nutrition Examination Survey 2005–2018. Frailty status was assessed using a validated 49-item index (non-frail ≤0.21; frail >0.21). The DI-GM (range 0–10) was derived from 14 microbiota-linked dietary components through two 24-h recall interviews. Multivariable logistic regression with sensitivity analyses, restricted cubic splines (RCS), stratified analyses, and mediation effect were implemented to systematically evaluate DI-GM-frailty associations.Results: Adjusted analyses revealed a dose-dependent inverse association between DI-GM and frailty (OR = 0.86, 95%CI: 0.84–0.88 per unit increase). RCS identified a nonlinear inflection at DI-GM = 4.082 (p for nonlinearity = 0.031), beyond which each unit elevation corresponded to 12.6% reduced frailty probability (OR = 0.874, 95%CI: 0.806–0.947). Stratified analyses demonstrated enhanced protective effects in women (OR = 0.84 vs. male 0.90; p for interaction = 0.011) and college-educated individuals (OR = 0.85 vs. 0.93; p for interaction = 0.031). Mediation analysis indicated BMI mediated 38.28% (95%CI: 26.62–62.6, p < 0.001) of the DI-GM effect on frailty progression.Conclusion: Higher DI-GM scores associate with lower frailty prevalence, particularly among women and highly-educated populations, partially mediated through BMI modulation. These findings establish DI-GM as a microbiota-targeted nutritional guideline for age-related frailty interventions, bridging dietary patterns with microbial homeostasis in geriatric care.

Purpose: This study aimed to detect differences in post-exercise brain activity between the left and right paddlers due to exercise by analyzing the resting-state electroencephalogram (EEG) power spectrum before and after exercise. Methods: Twenty-one right paddlers and twenty-two left paddlers completed a 1 km all-out test on a dragon boat ergometer, and their heart rate and exercise time were recorded. EEG signals were collected from superficial brain layers before and after exercise; then, the EEG power spectrum was extracted and compared in different frequency bands. In addition, the degree of lateralization in each brain region was assessed by the asymmetry index. Results: There was no significant difference in the power spectrum values and asymmetry indices between the left and right paddlers before rowing (p ˃ 0.05). However, after rowing, the left-paddlers group had significantly higher spectral power values in θ and α bands than the right-paddlers group (p < 0.05), and brain lateralization in both groups of athletes occurred mainly in the ipsilateral hemisphere of the frontal and central regions. Conclusion: The 1 km of rowing induced more brain activation in the left paddlers, and both left and right paddlers showed functional aggregation of hemispheric lateralization.

Background: The dietary index for gut microbiota (DI-GM) holds promise for improving metabolic status, yet its mechanistic insight into metabolic syndrome (MetS) is unclear. Methods: In this cross-sectional study, we analyzed data from 20,800 participants in the NHANES (2005–2018). The DI-GM was developed based on dietary patterns, and MetS was defined according to the NCEP-ATP III criteria. Global DI-GM scores came from the Global Dietary Database (164 nations), with MetS burden estimation employing Global Burden of Disease data. We explored mediation by phenotypic age, insulin resistance (HOMA-IR), and inflammation. Secondary analyses involved subgroup stratification, restricted cubic splines (RCS), sensitivity testing, propensity score matching, and multiple imputations. Results: Globally, higher national DI-GM correlated inversely with metabolic risk factor frequency and major MetS sequelae. NHANES analysis found each one-unit DI-GM rise was associated with an 11% lower MetS likelihood (adjusted OR = 0.89, 95%CI: 0.87–0.91). RCS indicated a non-linear exposure–response curve, with prevalence reduction stabilizing above DI-GM = 4.972. Stratification showed significant effect modification by race/ethnicity, education, and income (p-interaction < 0.05). Mediation analysis identified significant roles for phenotypic aging (24.77%) and HOMA-IR (47.98%), but not inflammation (0.54%). Conclusions: A DI-GM-aligned diet correlated with lower MetS prevalence, with insulin sensitivity and phenotypic aging accounting for part of this association. Microbiota-targeted nutrition guidelines for MetS should prioritize metabolic health over anti-inflammation.

The aim of this study is to investigate the immunoprotective effect of Eucommia Ulmoides Polysaccharide (EUP) on intensive exercise mice. EUP were isolated and its physicochemical properties were analyzed. Meanwhile, an intensive exercise model of mice was established and EUP were orally treated during exercise and some immunological parameters were measured at the end of the training session, such as thymus and spleen index, lymphocytes proliferation, natural killer (NK) cells activity. The results showed that EUP was a polysaccharide-protein conjugates and significantly increased the spleen index and activities of NK cells. In conclusion, EUP can ameliorate the exercise-induced immunosuppression.

The low oxygen training (LOT) was characterized by improving exercise capacities, enhancing cardiovascular functional performances due to the stimulus of insufficient oxygen and a series of physiological adaptions post-LOT. However, it is still unclear of the detailed research advances and potential new study hotspot. In the current study, we hackled the regulatory effects of LOT stimulus on individual’s certain physiological performances and elaborated intrinsic mechanisms by focusing on changes of physiology and biochemistry with literature consultation, thereby exploring new study spot.