Post-acute sequelae of SARS-CoV-2 infection (long COVID) present with persistent fatigue, cognitive impairment, and autonomic and multisystem dysfunctions that often go unnoticed by standard diagnostic tests. Increasing evidence suggests that mitochondrial dysfunction and oxidative stress are central drivers of these post-viral sequelae. Viral infections, particularly SARS-CoV-2, disrupt mitochondrial bioenergetics by altering membrane integrity, increasing mitochondrial reactive oxygen species (mtROS), and impairing mitophagy, leading to sustained immune activation and metabolic imbalance. This review synthesizes an understanding of how mitochondrial redox signaling and impaired clearance of damaged mitochondria contribute to chronic inflammation and multisystem organ symptoms in both long COVID and post-vaccine injury. We discuss translational biomarkers and non-invasive techniques, exploring therapeutic strategies that include pharmacological, non-pharmacological, and nutritional approaches, as well as imaging modalities aimed at assessing and restoring mitochondrial health. Recognizing long COVID as a mitochondrial disorder that stems from redox imbalance will open new options for personalized treatment and management guided by biomarkers. Future clinical trials are essential to validate these approaches and translate mitochondrial resuscitation into effective care for patients suffering from long COVID and related post-viral syndromes.

Climate change is changing how emerging infectious diseases (EIDs) spread over the world. The ecological conditions in which diseases, vectors, and hosts interact are changing because of rising temperatures, shifting patterns of rainfall, and increasingly frequent extreme weather events. This narrative review compiles existing research on climate-sensitive infectious illnesses and elucidates the principal mechanisms influencing observed changes. Food- and water-borne illnesses (e.g., cholera, leptospirosis) are increasingly linked to droughts, floods, and disruptions in infrastructure. Vector-borne diseases like dengue, chikungunya, malaria, and Lyme disease are spreading to highland and temperate areas. At the same time, zoonotic spillovers like Ebola, Nipah, and SARS-CoV-2 are happening more commonly in areas where the ecosystem has been altered. New worries are thermotolerant fungal infections and microorganisms that live in permafrost. This review does not offer new epidemiological modelling; instead, it puts recent Global Burden of Disease (GBD) estimates into context. These estimates reveal that the burden of infectious diseases is rising in regions that are sensitive to climate change, including sub-Saharan Africa, South Asia, and Latin America. Weak surveillance systems, health disparities caused by climate change, and broken data streams are some of the biggest gaps in response. Improvements in AI-based forecasting, satellite surveillance, pathogen genomes, and One Health methods provide useful tools for taking action before something happens. It is important to build public health systems that are climate-responsive, transdisciplinary, and fair in order to reduce the growing dangers posed by infectious illnesses connected to climate change.