Background/Objectives: This retrospective observational study aimed to analyze blood component utilization patterns and investigate associations between patient demographics, clinical parameters, and transfusion requirements at a major tertiary care center. Methods: The study analyzed data from 2867 patients at King Saud Medical City, Riyadh. Utilization patterns and correlations were assessed for packed red blood cells (PRBCs), fresh frozen plasma (FFP), platelets, and cryoprecipitate. Results: Significant correlations were found between age, hemoglobin levels, platelet counts, ferritin levels, and transfusion of specific components. Elderly patients received more PRBCs, FFP, and platelets, while younger patients received more cryoprecipitate. Hemoglobin < 7 g/dL was the most common trigger for PRBC transfusion. Platelet transfusions correlated strongly with thrombocytopenia, and elevated ferritin levels correlated with higher platelet transfusion volumes. Patients with hematologic malignancies, β-thalassemia, and sickle cell disease demonstrated distinct transfusion profiles. Conclusions: These findings underscore the importance of tailored, evidence-based transfusion strategies to optimize blood use and minimize risk.

Newborn screening is a public health program designed to detect severe inherited disorders in newborns within the first days of a baby’s life. This study assessed the influence of quality pro-cesses in NBS laboratories through testing NBS panels, including GALT, TSH, G6PD, Leu, Met, Phe, C5, C6, C8, C10, C14, and C14:1, under 4˚C, 20˚C, and -50˚C for two months. Results found that sam-ples can be stored at -50°C to maintain stability for most parameters in the NBS panel. The study shows methionine is recognized for its low stability among amino acids at room temperature and GALT among enzymes under all conditions. Moreover, different storage conditions might apply de-pending on the tested analyte of the NBS panel. Therefore, improving the quality process of the NBS laboratory can prevent false positive results and enable the re-use of samples after a period.