Carla Boga

Prof. Dr. Carla Boga

University of Bologna (Italy)
orcid

Research Focus & Metrics

Academic Career Length

41Years (1986-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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27 December 2002 in Arkivoc
Verified
Journal Article
Open access
LFLuciano Forlani
Luciano Forlani
GCGiampiero Cristoni
Giampiero Cristoni
Carla BogaCarla Boga
Carla Boga
PTPaolo E. Todesco
Paolo E. Todesco
EVErminia Del Vecchio
Erminia Del Vecchio
MMMagda Monari
Magda Monari

1 April 2013 in Dyes and Pigments
Verified
Journal Article
Closed access
Carla BogaCarla Boga
Carla Boga
CDCamila Delpivo
Camila Delpivo
BBBarbara Ballarin
Barbara Ballarin
MMMarco Morigi
Marco Morigi
SGSamanda Galli
Samanda Galli
STSilvia Tozzi
Silvia Tozzi

1 March 2015 in European Journal of Medicinal Chemistry
Verified
Journal Article
Closed access
Elena ChugunovaElena Chugunova
Elena Chugunova
Carla BogaCarla Boga
Carla Boga
ISIvan Sazykin
Ivan Sazykin
SCSilvia Cino
Silvia Cino
GMGabriele Micheletti
Gabriele Micheletti
NKNatalia Kostina
Natalia Kostina

17 May 2005 in Angewandte Chemie International Edition
Verified
Journal Article
Closed access
PDF file
Carla BogaCarla Boga
Carla Boga
EVErminia Del Vecchio
Erminia Del Vecchio
LFLuciano Forlani
Luciano Forlani
AMAndrea Mazzanti
Andrea Mazzanti
PTPaolo E. Todesco
Paolo E. Todesco

1 May 1991 in Journal of Molecular Catalysis
Verified
Journal Article
Closed access
CBC. Botteghi
C. Botteghi
SPS. Paganelli
S. Paganelli
ASA. Schionato
A. Schionato
Carla BogaCarla Boga
Carla Boga
AFA. Fava
A. Fava

1 August 2005 in Journal of Lipid Research
Verified
Journal Article
Open access
PDF file
NCNatalia Calonghi
Natalia Calonghi
CCConcettina Cappadone
Concettina Cappadone
Eleonora PagnottaEleonora Pagnotta
Eleonora Pagnotta
Carla BogaCarla Boga
Carla Boga
CBCarlo Bertucci
Carlo Bertucci
LMLanfranco Masotti
Lanfranco Masotti
Recent studies have shown that an endogenous lipoperoxidation product, 9-hydroxystearic acid (9-HSA), acts in colon carcinoma cells (HT29) as a growth inhibitor by inducing p21WAF1 in an immediate-early, p53-independent manner and that p21WAF1 is required for 9-HSA-mediated growth arrest in HT29 cells. It is conceivable, therefore, to hypothesize that the cytostatic effect induced by this agent is at least partially associated with a molecular mechanism that involves histone deacetylase 1 (HDAC1) inhibition, as demonstrated for sodium butyrate and other specific inhibitors, such as trichostatin A and hydroxamic acids. Here, we show that, after administration, 9-HSA causes an accumulation of hyperacetylated histones and strongly inhibits the activity of HDAC1. The interaction of 9-HSA with the catalytic site of the enzyme has been highlighted by computational modeling of the human HDAC1, using its homolog from the hyperthermophilic Aquifex aeolicus as a template.