Potentially malignant diseases of the oral mucosa that have a risk of conversion to oral squamous cell carcinoma, are described as precancer, premalignant, intraepithelial neoplasia, and potentially malignant disorders. The etiology includes oral habits associated with tobacco, heavy alcohol, betel nut chewing, and human papilloma virus (HPV) infection. Diagnosis of OPLs typically relies on visual observation by experienced practitioners followed by biopsy and analysis under a microscope. The main purpose of this study was epidemiological and clinical analysis of patients with oral premalignant lesions diagnosed and treated in our collaborative healthcare structures. Oral premalignant lesions were more common in men than women. Buccal mucosa was the most common location of oral premalignant lesions in our study (31.03%), followed by floor of the mouth (22.4%). Homogenous leukoplakia was the most common type of leukoplakia (present in 44.8% of patients), followed by lichen planus (25.8%). The degree of dysplasia was associated with the type of oral premalignant lesions but not significantly with their size.

Background: Treatment of peri-implantitis remains challenging because biofilm removal from microstructured implant surfaces is often incomplete. The present study is an uncontrolled, prospective feasibility case series involving six patients (six implants), not a controlled clinical trial, in which short-term clinical outcomes following use of a multimodal protocol to decontaminate the titanium implant surface were obtained; consequently, the independent contribution of the Ximplant^® device to the observed outcomes cannot be determined. The protocol comprised surgical access, mechanical debridement, chemical conditioning, systemic administration of medication, and cleaning with an alternating-current device (Ximplant^®; LED, S.p.A., Aprilia, Italy). Methods: Six adults with peri-implantitis, each contributing one implant, were consecutively treated using the multimodal protocol. Probing depth (PD), bleeding on probing (BOP), plaque index (PI), and suppuration (SU) were determined at baseline, 3 weeks, 6 months, and 12 months. Longitudinal changes were analyzed using repeated-measures analysis of variance and non-parametric tests for categorical variables. Results: Mean total PD decreased from 4.56 ± 0.45 mm at baseline to 3.03 ± 0.44 mm at the 3-week follow-up and remained stable at the 6-month follow-up (3.08 ± 0.35 mm) and at 12-month follow-up (3.19 ± 0.41 mm; p < 0.0001). BOP and SU were absent in all implants at each follow-up visit. PI improved markedly, although the buccal aspect of one implant was PI-positive at the 3-week and the 12-month follow-up. Conclusions: The multimodal protocol used in this study was associated with rapid and sustained clinical improvement over the 12-month follow-up period. A study limitation is that because the individual parts of the protocol were applied concurrently, the independent contribution of any of them to the outcomes determined could not be isolated.