Since carbon quantum dots have high photoluminescent efficiency, it has been a desired material in sensor and bioimaging applications. In recent years, the green chemistry approach has been preferred and the production of quantum dots has been reported in many studies using different precursors from natural, abundant, or waste sources. Hydrothermal, chemical oxidation, microwave supported, ultrasonic, solvothermal, pyrolysis, laser etching, solid-state, plasma, and electrochemical methods have been reported in the literature. In this review article, green chemistry strategies for carbon quantum dot synthesis is summarized and compared with conventional methods using methodologic and statistical data. Furthermore, a detailed discussion on sensor and bioimaging applications of carbon quantum dots produced with green synthesis approaches are presented with a special focus on the last decade. Graphical Abstract