Şizofreni her türlü toplumda en sık görülen ruhsal bozukluklardan biridir. Şizofreninin özellikleri ve tedavisi ile ilgili literatürde oldukça fazla çalışma yapıldığı görülmüştür. Epidemiyolojik çalışmalarda genel olarak kadın ve erkeklerde görülme sıklığının eşit ve başlangıç yaşının erkeklerde daha erken olduğu, sosyoekonomik düzeyi düşük ailelerde şizofreniye daha sık rastlandığı saptanmıştır. Etiyolojik çalışmalarda ise şizofrenin genetik, nörodejeneratif, nörogelişimsel ve nörokimyasal modellerde açıklandığı görülmüştür. Hastalık başlangıcın akut ve sinsi olabildiği gibi prodromal belirtiler de görülebildiği yine yapılan çalışmalarda belirtilmiştir. Bu çalışmada, şizofrenide sosyodemografik, klinik özellikler ve hastalığın temel belirtileri incelenmiştir.

Background and Objectives: Chronic mental disorders may negatively affect sexual functioning and dyadic adjustment. This study aimed to investigate the associations between alexithymia, sexual dysfunctions, and dyadic adjustment in patients with obsessive–compulsive disorder (OCD) and to compare these variables with those of healthy controls. Materials and Methods: This case–control study included 72 patients with OCD and 82 sociodemographically matched healthy controls. All participants completed the Toronto Alexithymia Scale (TAS-20), Arizona Sexual Experiences Scale (ASEX), Yale–Brown Obsessive Compulsive Scale (YBOCS), and Dyadic Adjustment Scale (DAS). Group comparisons were conducted using independent t-tests, Mann–Whitney U tests, and chi-square tests, while correlations were examined using Pearson’s analysis. Results: Patients with OCD had significantly higher TAS-20 scores (60.97 ± 11.15 vs. 43.18 ± 8.86, p < 0.001) and ASEX total scores (18.33 ± 4.93 vs. 13.76 ± 3.55, p < 0.001), alongside lower DAS scores (total and all subscales, p < 0.001) than controls. Within the OCD group, TAS-20 scores correlated positively with the total ASEX score (r = 0.366, p = 0.002) and negatively with the total DAS score (r = −0.339, p = 0.004) and subscales (all p < 0.05). Conclusions: Patients with OCD exhibit elevated alexithymia, greater sexual dysfunction, and reduced dyadic adjustment compared with healthy controls. Furthermore, alexithymia in patients with OCD is associated with impaired sexual functioning and dyadic adjustment. Assessing alexithymic traits and addressing them in treatment may improve social and familial functioning in this population.

(2017). 9th International Congress on Psychopharmacology & 5th International Symposium on Child and Adolescent Psychopharmacology. Psychiatry and Clinical Psychopharmacology: Vol. 27, 9th International Congress on Psychopharmacology & 5th International Symposium on Child and Adolescent Psychopharmacology Abstracts, pp. 47-84.