Hemolytic disease of the fetus and newborn (HDFN) is the development of anemia, hyperbilirubinemia, and finally hydrops fetalis in the fetus when antibodies to antigens on the surface of erythrocytes are transferred from the placenta to the fetus. The most common cause is D‐HDFN. K (KEL1) from the Kell blood group system is the most potent immunogenic antigen after D among all blood group antigens. K‐HDFN occurs in 0.1–0.3% of pregnant women. It accounts for 10% of cases of antibody‐mediated severe fetal anemia. We present a successful management of Kell alloimmunization in a pregnant woman who had 3 times pregnancy loss with hydrops fetalis due to K‐HDFN and who was proven to have K‐HDFN in the postnatal period in her last pregnancy.

Evaluation of prenatal and postnatal outcomes of fetuses with intrauterine cardiac anomalies: Tertiary center experience - Turkish Journal of Obstetrics and Gynecology

Gebelikte Radyasyon Maruziyeti Ahmet Eren ŞEN Mustafa EROL Gebelikte Üriner Sistem Hastalıkları İhsan ŞAFAK Endometriyum ve Serviks Malignitelerinde Fertilite Koruyucu Yaklaşım Mürşide ÇEVİKOĞLU KILLI Gebelik ve Gastointestinal Sistem Hastalıkları İhsan ŞAFAK Gebelikte Antifosfolipid Sendromunun Etkileri ve Yönetimi Yusuf DAL Kadın İnfertilitesine Yaklaşım Feden Kübra ÖZDİLEK KIRÇİÇEĞİ Hipertansif Gebeliklerde Umblikal Doppler Rezistans İndeksinin Önemi Gülay BALKAŞ Gebelik ve Migren Utku AKGÖR Nonimmun Hidrops Fetalis Serdar AYKUT Teratojenler Mesut AVAN

Prenatal diagnosis of hemoglobinopathies by chorionic villus sampling: A large single-center experience - Turkish Journal of Obstetrics and Gynecology

Iniencephaly is a rare and severe neural tube defect characterized by an occipital bone defect, partial or complete absence of the cervicothoracic vertebrae, and marked hyperextension of the fetal head. Its reported incidence ranges between 0.0001% and 0.01%, with a significantly higher prevalence in female fetuses. Iniencephaly is classified into two types: iniencephaly apertus and iniencephaly clausus.As a neural tube defect, preconceptional folic acid supplementation plays a crucial role in its prevention. Early prenatal diagnosis is essential for appropriate counseling and management, particularly given that the condition is generally incompatible with life. Timely identification allows consideration of pregnancy termination, thereby reducing potential maternal morbidity and psychological burden.Herein, we present two prenatally diagnosed cases: one of iniencephaly apertus detected in the first trimester and one of iniencephaly clausus diagnosed in the third trimester.

Background: We aimed to compare the perinatal outcomes of dichorionic/diamniotic twin (DC/DA) pregnancies resulting from in vitro fertilization (IVF) with those resulting from spontaneous DC/DA pregnancies. Methods: The study group included 99 women with DC/DA pregnancies resulting from IVF, and the control group included 92 women with spontaneous DC/DA pregnancies. Maternal demographic characteristics (age, parity, and gravidity), pre-existing conditions (chronic hypertension and pregestational diabetes mellitus), and obstetric history were recorded. Pregnancy outcomes included gestational age at delivery, number of fetuses, and mode of delivery. The antepartum complications that we evaluated include first- and second-trimester bleeding, placenta previa, preterm birth, fetal growth restriction (FGR), oligohydramnios, and tocolytic use. The obstetric complications that we assessed include prematurity, twin-to-twin transfusion syndrome (TTTS), and hydrops fetalis. Additionally, neonatal data such as 1st minute and 5th minute Apgar scores, birth weight, neonatal intensive care unit (NICU) admission, presence of congenital anomalies, and neonatal death were recorded, and comparisons were made between the groups. Results: Women in the IVF group were older (34.7 ± 6.9 vs. 32.3 ± 6.1 years, p = 0.03) and more frequently primiparous (73.7% vs. 37.0%, p < 0.001). The mean gestational age at delivery was slightly lower in the IVF group, though this was not statistically significant (34.3 ± 3.5 vs. 35.1 ± 2.5 weeks, p = 0.101). Cesarean delivery was common in both groups, with comparable overall rates (90.9% vs. 94.6%, p = 0.411), but emergency cesarean section occurred more frequently in IVF pregnancies (81.8% vs. 55.8%, p = 0.001). No significant differences were found regarding chronic hypertension or pregestational diabetes. However, several differences were demonstrated in terms of obstetric complications. For example, preterm births and fetal growth restriction (FGR) were significantly more frequent in IVF pregnancies (59.8% vs. 30.4%, p < 0.001), and tocolytic use was also more frequent (56.6% vs. 29.7%, p < 0.001). No significant differences were observed in terms of placenta previa, oligohydramnios, TTTS, hydrops fetalis, and neonatal outcomes. The logistic regression analysis revealed that IVF pregnancies were associated with an increased risk of preterm birth: OR 3.45, 95% CI 1.85–6.78 (p < 0.001); the risk of FGR was also higher in IVF pregnancies: OR 2.11, 95% CI 1.02–4.37 (p = 0.015). However, tocolytic use was not significantly associated with IVF: OR 1.49, 95% CI 0.50–4.44 (p = 0.471). Conclusions: Although DC/DA pregnancies conceived through IVF have a higher risk of preterm birth, fetal growth restriction, and greater use of tocolytic agents than spontaneous DC/DA pregnancies, their neonatal outcomes are similar.