The Great Hinggan Range (GHR) hosts many large Mo deposits and vein-type Pb-Zn deposits and is one of the most important polymetallic metallogenic belts in China. Although Mo and Pb-Zn deposits are locally closely related in space in the GHR, it is disputed whether the Mo and Pb-Zn deposits have a genetic relationship. The Diyanqinamu Mo deposit located at the middle part of the northern GHR is a Late Jurassic large porphyry Mo deposit and closely adjacent by vein-type Pb-Zn deposit. In this work, we discussed the relationship between Mo and Pb-Zn deposits in Diyanqinamu mine based on the data of S and Pb isotopic geochemistry and geological information. In this mine, the Mo deposit is concentrated in the southern area with a distance of 500 m to the vein Pb-Zn deposit. The δ³⁴S_CDT values of the galena and sphalerite from the Mo deposit range from +1.73‰ to +7.29‰ with average of +5.04‰. By contrast, δ³⁴S_CDT values of the galena and sphalerite from the Pb-Zn deposit, ranging from +2.38‰ to +5.46‰ with average of +4.04‰, is similar to that of the Mo deposit. The formation temperatures of the Pb-Zn deposit calculated based on the sulfur isotope balance fractionation between sphalerite and co-existed galena range from 220 °C to 315 °C (average 247 °C), which is lower than that of the Mo mineralization (292–510°C). Pb isotopic results show that the ²⁰⁶Pb/²⁰⁴Pb, ²⁰⁷Pb/²⁰⁴Pb, and ²⁰⁸Pb/²⁰⁴Pb values of the Pb-Zn deposit range from 18.326–18.364, 15.541–15.589, and 38.054–38.214, respectively, which are slightly higher than those of the Mo deposit ranging from 18.287–18.331, 15.532–15.569, and 38.034–38.139, respectively. In the ²⁰⁶Pb/²⁰⁴Pb˗²⁰⁷Pb/²⁰⁴Pb diagram, sulfides sampled from the Mo and Pb-Zn deposits overlapped with each other and formed a linear distribution, indicating that they are derived from a mixed metal source with more external contribution to the Pb-Zn mineralization. This mixed signal is further confirmed by the geologic facts that the host rocks of the vein-type Pb-Zn deposit have abnormally high contents of Pb, Zn, and Ag, and experienced strong hydrothermal alteration. Combined with the ore geology, mineral assemblage, and isotopic geochemistry of the two types of mineralization, we propose that the Mo and Pb-Zn deposits in the Diyanqinamu mine represent different faces of the same porphyry system. This Mo-Pb-Zn metallogenic system would provide important clues on further prospecting of Mo and Pb-Zn resources in the GHR.