Background: Physical activity (PA) is essential for the overall physical, mental, and psychological health of university students. However, participation rates remain low, particularly in developing regions such as Libya. Materials and Methods: This cross-sectional study involved 768 university students who completed self-administered questionnaires assessing PA engagement, motivations, and barriers to participation. Results: The findings revealed that 60.5% of participants were physically inactive, highlighting a significant public health concern. Among inactive participants, the most prevalent external barriers were time constraints (3.45 ± 1.07), limited resources (3.22 ± 0.97), and lack of support (2.96 ± 1.01). values are presented as mean ± standard deviation (SD). The primary motivating factors for PA were health improvement (3.95 ± 0.96) and revitalization (3.93 ± 1.01). Notably, gender differences emerged: male students reported higher motivation for competition and enjoyment, while female students were primarily motivated by weight management. Furthermore, female students reported significantly higher scores for both internal and external barriers than their male counterparts, indicating greater challenges faced in engaging with PA. The study also found a pronounced decrease in PA levels during the college years, suggesting that the transition to university life contributes to reduced activity. Conclusions: This study highlights the critical need for focused strategies to increase student participation in PA and address the identified barriers. Understanding both motivational aspects and barriers is essential for promoting healthier lifestyles among university students in Libya, which could ultimately lead to better health outcomes and fostering a more physically active student community.

Cancer remains a major global health challenge, requiring new adjunctive therapies. Integrative oncology, which combines conventional treatments with complementary agents, has gained attention for improving patient outcomes. Melatonin, a potent antioxidant and immunomodulator, has shown promise in cancer therapy. Recent evidence suggests that combining melatonin with vitamins—particularly vitamin D, vitamin C, and vitamin E—may enhance its anticancer effects through synergistic mechanisms. Melatonin exerts anticancer effects by regulating oxidative stress, apoptosis, and immune responses. Vitamin D enhances immune modulation, while vitamins C and E provide antioxidant and cytoprotective benefits. Their combined action may improve tumor suppression and reduce treatment-induced toxicity. However, despite promising preclinical data, clinical studies on melatonin–vitamins synergy remain limited. This review explores the molecular interactions, current evidence, and research gaps in melatonin–vitamin combinations for cancer therapy. Future studies should focus on mechanistic insights, optimal dosing, and clinical trials to establish their role in integrative oncology. Unlocking this potential could enhance existing cancer treatment strategies and improve patient outcomes.

Background: The 24-hour movement behavior (24HMB) framework integrates physical activity, sedentary behavior, and sleep into a single health paradigm. University students are known to be vulnerable to inadequate movement patterns. However, no previous study has compared adherence to the 24HMB guidelines across the Visegrad Group (V4) countries (Czech Republic, Hungary, Poland, Slovakia). Material and methods: This cross-sectional study included 2,611 university students aged 18-29 years. Movement behaviors were assessed using the International Physical Activity Questionnaire – Long Form (IPAQ-LF) and self-reported sleep duration. Guidelines adherence was defined as meeting all three components: ≥150 minutes/week of moderate-to-vigorous physical activity (MVPA), ≤8 hours/day of sedentary time, and ≥7 hours of sleep. Descriptive statistics and Chi-square tests were applied to examine gender and country differences using IBM SPSS 29.0 software. Results: Overall, 44.24% of students met the physical activity guideline, 82.27% met the sedentary behavior guideline, and 85.43% met the sleep guideline. Only 26.92% adhered to all three 24HMB recommendations. Significant differences were observed across countries for physical activity (p<0.001) and sleep (p=0.025), but not for sedentary time or full adherence. Conclusions: Adherence to the integrated 24HMB guidelines is low among V4 university students, highlighting the need for coordinated, context-specific interventions.