1. Department of Electronic Engineering, The Chinese University of Hong Kong, Shatin, N.T.,Hong Kong SAR, China</br>2. Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, China
Prof. Dr. Jian-Bin Xu
1. Department of Electronic Engineering, The Chinese University of Hong Kong, Shatin, N.T.,Hong Kong SAR, China</br>2. Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, China
Magnetic microrobots and nanorobots can be remotely controlled to propel in complex biological fluids with high precision by using magnetic fields. Their potential for controlled navigation in hard-to-reach cavities of the human body makes them promising miniaturized robotic tools to diagnose and treat diseases in a minimally invasive manner. However, critical issues, such as motion tracking, biocompatibility, biodegradation, and diagnostic/therapeutic effects, need to be resolved to allow preclinical in vivo development and clinical trials. We report biohybrid magnetic robots endowed with multifunctional capabilities by integrating desired structural and functional attributes from a biological matrix and an engineered coating. Helical microswimmers were fabricated from Spirulina microalgae via a facile dip-coating process in magnetite (Fe3O4) suspensions, superparamagnetic, and equipped with robust navigation capability in various biofluids. The innate properties of the microalgae allowed in vivo fluorescence imaging and remote diagnostic sensing without the need for any surface modification. Furthermore, in vivo magnetic resonance imaging tracked a swarm of microswimmers inside rodent stomachs, a deep organ where fluorescence-based imaging ceased to work because of its penetration limitation. Meanwhile, the microswimmers were able to degrade and exhibited selective cytotoxicity to cancer cell lines, subject to the thickness of the Fe3O4 coating, which could be tailored via the dip-coating process. The biohybrid microrobots reported herein represent a microrobotic platform that could be further developed for in vivo imaging–guided therapy and a proof of concept for the engineering of multifunctional microrobotic and nanorobotic devices.
17 March 2015 in Journal of the American Chemical Society
The exfoliation and identification of the two-dimensional (2D) single atomic layer of carbon have opened the opportunity to explore graphene and related 2D materials due to their unique properties. 2D materials are regarded as one of the most exciting solutions for next generation electronics and optoelectronics in the technological evolution of semiconductor technology. In this review, we focus on the core concept of “structure-property relationships” to explain the state-of-the-art of 2D materials and summarize the unique electrical and light-matter interaction properties in 2D materials. Based on this, we discuss and analyze the structural properties of 2D materials, such as defects and dopants, the number of layers, composition, phase, strain, and other structural characteristics, which could significantly alter the properties of 2D materials and hence affect the performance of semiconductor devices. In particular, the building blocks principles and potential electronic and optoelectronic applications based on 2D materials are explained and illustrated. Indeed, 2D materials and related heterostructures offer the promise for challenging the existing technologies and providing the chance to have social impact. More efforts are expected to propel this exciting field forward.
The mid-infrared (MIR) spectral range, pertaining to important applications, such as molecular “fingerprint” imaging, remote sensing, free space telecommunication, and optical radar, is of particular scientific interest and technological importance. However, state-of-the-art materials for MIR detection are limited by intrinsic noise and inconvenient fabrication processes, resulting in high-cost photodetectors requiring cryogenic operation. We report black arsenic phosphorus–based long-wavelength IR photodetectors, with room temperature operation up to 8.2 μm, entering the second MIR atmospheric transmission window. Combined with a van der Waals heterojunction, room temperature–specific detectivity higher than 4.9 × 109 Jones was obtained in the 3- to 5-μm range. The photodetector works in a zero-bias photovoltaic mode, enabling fast photoresponse and low dark noise. Our van der Waals heterojunction photodetectors not only exemplify black arsenic phosphorus as a promising candidate for MIR optoelectronic applications but also pave the way for a general strategy to suppress 1/f noise in photonic devices.