(1) Background: Gastric cancer (GC) remains a major global health challenge due to its high heterogeneity and aggressive progression. The discovery of novel bioactive molecules with anticancer properties has, therefore, become a critical research focus. In this study, we synthesized and characterized 4,4′-(5,8-dioxa-2,11-diazadodecane-1,11-diene-1,12-diyl)diphenol (DODP) and evaluated its anticancer potential using molecular docking, bioinformatics, and experimental analyses. (2) Methods: The chemical structure of DODP was confirmed through ¹H and ¹³C NMR spectroscopy. Molecular docking was conducted to examine the interaction of DODP with apoptosis and cell cycle-related proteins (TP53, MDM2, and MYC) and the immune checkpoint marker CD274 (PD-L1). Cytotoxicity against AGS GC cells was determined using the MTT assay at concentrations ranging from 0.01 to 50 µM, and gene expression alterations were analyzed by quantitative polymerase chain reaction (qPCR) and bioinformatics evaluation. (3) Results: NMR data verified the successful synthesis of DODP. The docking results indicated strong binding affinity, especially with TP53 and CD274. DODP showed notable cytotoxicity after 72 h of exposure and induced upregulation of TP53, MYC, and CD274 and downregulation of MDM2 in AGS cells. Although the patterns were consistent with cell-based and bioinformatic analyses, significant discriminatory ability in blood samples was observed only for MYC (AUC = 0.651; p = 0.044). (4) Conclusions: DODP influenced apoptosis-associated transcriptional responses in GC, offering early mechanistic evidence that should be evaluated in more comprehensive biological models.

Objectives: Acute peritonitis remains a critical condition with high mortality rates, further complicated by the rising antibiotic resistance. This study aimed to investigate the therapeutic potential of Chlorella vulgaris (CHL), both alone and in combination with standard antibiotic therapy (SFT), in a rat model of cecal ligation and puncture (CLP)-induced peritonitis. Methods: Seventy (70) male Wistar albino rats were divided into seven groups (n = 10): Control, Peritonitis Control, Low-dose CHL (CHL I) (150 mg/kg), High-dose CHL (CHL II) (300 mg/kg), the standard first-line therapy group (SFT) (Ceftriaxone + Metronidazole), SFT + CHL I, and SFT + CHL II. Following CLP-induced peritonitis, treatments were administered for 7 days. Peritoneal tissues were evaluated histopathologically and immunohistochemically for TNF-α, IL-1β, IL-10, and iNOS expression. Total Antioxidant Status (TAS) and Total Oxidant Stress (TOS) were measured to assess the oxidative stress. Results: Histopathological analysis showed that CLP-induced severe inflammatory damage was significantly reduced in all treatment groups, with the most prominent recovery observed in the SFT + CHL II group. CHL treatment led to a significant decrease in pro-inflammatory markers (TNF-α, IL-1β, iNOS) compared to the peritonitis control group (PC) (p < 0.05). Furthermore, CHL administration significantly improved the oxidative balance by increasing TAS and reducing TOS levels. Conclusions: Chlorella vulgaris exhibits significant anti-inflammatory, antioxidant, and immunomodulatory properties in experimental peritonitis. When used as an adjunct to standard antibiotic therapy, high-dose CHL provides synergistic effects that contribute to limiting tissue damage and controlling systemic inflammation. These findings suggest that CHL may be a promising supportive agent in the clinical management of acute peritonitis.

BACKGROUND Delayed graft function remains a common and clinically relevant complication following kidney transplantation, yet reliable early prediction tools are limited. This small-scale, retrospective, exploratory study investigated whether routine hematologic inflammatory indices, such as the systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), and prognostic inflammatory value (PIV), when considered alongside donor-recipient demographic characteristics, predict the need for early posttransplant dialysis. MATERIAL AND METHODS Retrospective analysis of 33 cadaveric kidney transplant recipients was performed. Catorigization into dialysis (n=14) and non-dialysis (n=19) groups was based on early posttransplant dialysis requirement. SII, SIRI, and PIV were calculated from pretransplant laboratory parameters. Given the exploratory study design, analyses were primarily descriptive, supported by univariate comparisons and logistic regression with bootstrap resampling. RESULTS Recipients requiring dialysis tended to receive kidneys from older donors, although this did not reach statistical significance. Monocyte count was significantly lower in the dialysis group (P=0.032). Inflammatory indices, including SII, SIRI, and PIV, showed no significant differences (P>0.05). Logistic regression analyses did not identify SII, SIRI, or PIV as independent dialysis predictors. However, bootstrap resampling showed consistent, although non-significant, directional trends, suggesting higher donor age and inflammatory burden among recipients requiring dialysis. CONCLUSIONS This study provides preliminary insights into the potential role of combined hematologic inflammatory indices in the context of delayed graft function, underscoring the need for larger, prospective studies to clarify whether inflammatory burden and donor-related factors can be integrated into clinically useful prediction models for early dialysis after kidney transplantation.

(1) This cross-sectional study aims to elucidate the association between the XPO5 gene polymorphism (rs11544382) and colon cancer (CC). (2) Genotyping of XPO5 (rs11544382) was performed in 120 individuals (60 CC patients and 60 controls) using real-time PCR (qPCR). Logistic regression and Chi-square (χ²) tests were used for statistical analysis. (3) Evaluation of the XPO5 gene polymorphism in CC and control groups revealed no statistically significant association between the mutant (GG) genotype and either the wild-type (AA) or heterozygous (AG) genotypes (χ² = 2.07, p = 0.151). The AG genotype was predominant in both patients (86.7%) and controls (91.7%). Smoking and alcohol consumption showed significant associations with CC (p < 0.05). Although the rs11544382 polymorphism was not associated with CC risk, this is a cross-sectional study. In light of these findings, larger and more comprehensive studies with increased sample size are required to clarify the relationship between the XPO5 gene polymorphism (rs11544382) and CC.

Sindirim Sistemi Hastalıklarında Oral Bulgular Eyyüp TAŞDEMİR Gastroözofageal Reflü Hastalığı Feridun GÜRLEK Gardner Sendromu Arda YAVUZ Peutz-Jeghers Sendromu Kübra AKAN Hemorajik Hastalıklar Sibel AKPINAR TEKGÜNDÜZ AIDS Muammer ÇELİK Kollajen Doku Hastalıkları Suade Özlem BADAK Vitamin Eksiklikleri ve Malabsorbsiyonlar Murat KEMAHLI İnflamatuvar Barsak Hastalıkları Erhan ERGİN Kurşun Zehirlenmesi Uğur GÜLÖKSÜZ Plummer Vinson Sendromu Çınar YILDIRIM Halitozis Çınar YILDIRIM Disfaji Fatih KIVRAKOĞLU Odinofaji Nuran AY Globus Sensation-Boğazda Kitle Duygusu Hüseyin Samet KOCA Arzu OR KOCA Retrosternal Yanma (Heartburn) Işıl KİBAR AKILLI Kalp Dışı Göğüs Ağrısı Müge BİLGE Bulantı ve Kusmaya Yaklaşım Elif Tuğba TUNCEL İshal – Diyare Pınar ERGEN Konstipasyon Tedavi Sibel GÜRAY MUNGAN Dispepsi Sevil ÖZER SARI Meteorizm ve Aşırı Gaz Ülkü BULUT BATUR Aerofaji-Hava Yutma, Geğirme Mehmet Önder EKMEN Flatulans Mehmet KÖSTEK Akut ve Kronik GİS Kanamalar Bahar BEKTAN KANAT Hematokezya Halit Eyyüp MUNGAN Okült Kanamalar Saygın ALTINER Gaitada Gizli Kanama Nazif YALÇIN Özofajit ve Hiatus Hernisi/Mallory Weiss Sendromu Berrin YALINBAŞ KAYA Ersin AKGÖLLÜ Portal Hipertansiyona Bağlı Kanamalar Yavuz ÇAĞIR Hemorajik ve Erozif Gastrit Yonca YILMAZ ÜRÜN Malignitelere Bağlı GİS Kanamalar Rabia KÖKSAL Hemobilia ve Aortoenterik Fistüller Yusuf Murat BAĞ Vasküler Anomali ve Ektaziler Hatice KÖSTEK Alt GIS Kanama Yapan Nedenler Dursun Burak ÖZDEMİR Kilo Kaybına Neden Olan Psikiyatrik Bozukluklar Neslihan CANSEL Visseral Ağrılar ve Somatoparietal Ağrı Barış TÜRKER Akut Abdominal Ağrılı Hastaya Yaklaşım ve Fizik Muayene Kutay SAĞLAM Akut Apandisit Ahmet KARAYİĞİT Akut Kolesistit Hüsnü Çağrı GENÇ Akut Pankreatit Sanem KAYHAN Duodenum Ülseri Perforasyonu Ahmet Cem ESMER İnce Barsak Obstrüksiyonu Kutay SAĞLAM Akut Divertikülit Jale AYALOĞLU Akut Mezenter İskemisi ve Abdominal Aort Anevrizması Hilal KURTOĞLU GÜMÜŞEL Kadınlarda Genital Nedenli Karın Ağrıları Sümeyye ÇİÇEK Spontan Bakteriyel Peritonit Harun KÜÇÜK Toraks ve Pulmoner Kökenli Karın Ağrıları (Kardiyak Harici) Işıl KİBAR AKILLI Nörolojik Kökenli Karın Ağrıları Osman Bilge KAYA Metabolik Nedenlere Bağlı Karın Ağrıları Mustafa Gürkan HAYTAOĞLU Hematolojik Nedenlere Bağlı Karın Ağrıları Lale AYDIN KAYNAR Toksinlere Bağlı Karın Ağrısı Burçin UYGUN Enfeksiyonlara Bağlı Karın Ağrıları Özlem AYDIN Ailesel Akdeniz Ateşi Recep EVCEN Kronik Yineleyici Karın Ağrıları ve Kronik Devamlı Karın Ağrıları Salih CIRIK Kronik Epigastrik Ağrı Timur ORHANOĞLU Peptik Ülser Ağrısı ve Mide Kanseri Evren PEKER Akut ve Kronik Gastritler Gözde TÜRKEL Akut ve Kronik Mezenterik İskemiler Murat DEVECİ Sağ Üst Kadran Ağrıları Murat KESKİN Karın Sağ Alt Kadran Ağrıları Banu TAŞKIRAN TATAR Sol Üst Kadran Karın Ağrıları Rahmi ASLAN Sol Alt Kadran Ağrısı Ayşe KEFELİ Hipogastrium Ağrıları Ayşe Nilgün KUL GİS Endoskopik İnceleme ve GİS Endoskopi Endikasyonları Fatih COŞKUN Endoskopi Kontrendikasyonlar ve Komplikasyonları Bünyamin SARITAŞ ERCP (Endoskopik Retrograd Kolanjio-Pankreatografi) Fatma ERSEVEN Karın İnspeksiyonu Sabri Engin ALTINTOP Karın Palpasyonu Seval AKPINAR Karın Perküyonu (Perküsyon) Başak ÇAKIR GÜNEY Karın Oskültasyonu Mehmet ALPUA

Background: The role of routine preoperative upper gastrointestinal (GI) endoscopy in bariatric surgery remains controversial. This study aimed to evaluate the prevalence of endoscopic abnormalities and their impact on surgical decision-making. Methods: A retrospective analysis was conducted on 360 patients undergoing preoperative upper GI endoscopy prior to bariatric surgery. Demographics, GI symptoms, endoscopic findings, and subsequent changes in surgical planning were evaluated. Statistical analyses included chi-square and independent t -tests. Results: Of the 360 patients, 124 (34.4%) were symptomatic and 236 (65.6%) asymptomatic. Endoscopic abnormalities were detected in 215 patients (59.7%). These findings resulted in surgical plan modifications in 118 patients (32.8%). Symptomatic patients had significantly higher rates of abnormal findings compared with asymptomatic patients ( P < .001). Moreover, surgical modifications were significantly more frequent in symptomatic patients (51.6%) than in asymptomatic patients (22.9%) ( P < .001). Conclusions: Although preoperative endoscopy detects a high rate of abnormalities in bariatric candidates, its clinical impact is predominantly observed in symptomatic patients. This suggests that while endoscopic abnormalities are common, their clinical relevance is predominantly confined to symptomatic patients. A selective, symptom-based approach may therefore be more appropriate than routine endoscopy for all patients.