Background/Objectives: Walking impairment and fatigue are common in multiple sclerosis (MS) and contribute to reduced physical function and quality of life (QoL). This study evaluated the feasibility, safety, and pre–post changes associated with a 12-week treadmill walking training (TWT) programme on walking performance, physical function, fatigue, and QoL in people with MS. Methods: Single-arm pilot study with pre–post assessments (T1–T2). Eleven adults with MS (Expanded Disability Status Scale [EDSS] ≤ 6) completed supervised TWT for 12 weeks (two 25 min sessions/week) at the Complejo Asistencial Universitario de Soria (Spain). Outcomes included SF-36, Timed Up and Go (TUG), 4 m gait speed, Short Physical Performance Battery (SPPB), and Modified Fatigue Impact Scale (MFIS). Within-participant changes were analysed using paired t-tests or Wilcoxon signed-rank tests as appropriate; effect sizes were reported as appropriate for the statistical test. Results: SF-36 total score did not change significantly (p = 0.160), while general health (p = 0.039) and vitality (p = 0.043) improved. Walking performance improved (TUG, p = 0.007; 4 m gait speed, p < 0.001), and physical function increased (SPPB, p = 0.003). Fatigue impact decreased (MFIS total, p = 0.015; physical, p = 0.007; psychosocial, p = 0.026), whereas the cognitive subscale did not change significantly (p = 0.094). Adherence was 91.7%, and no adverse events were reported. Conclusions: In this pilot sample, a 12-week TWT programme was feasible and safe and was associated with improvements in walking performance, physical function, and fatigue, with QoL changes limited to specific SF-36 domains. These findings support proceeding to a randomised controlled trial to establish efficacy. These findings should be interpreted as preliminary and exploratory, given the single-arm pre–post study design.

Prolonged sitting (PS) in the workplace has been linked to a higher risk of developing non-communicable chronic diseases. Simultaneously, an elevated waist-to-height ratio (WHtR) is considered a reliable measure of increased risk for the same condition. The main objective of this research was to examine the relationship between workplace PS and increased WHtR among male workers from the Spanish region of Castilla y León. The secondary objective was to assess how age affects elevated WHtR in workers. This retrospective observational study was carried out in accordance with the STROBE guidelines. The sample included 85,670 male workers, categorized by job type (with or without PS) and age (<40 years or ≥40 years). Chi-square test (X²), Pearson correlation coefficients, and odd ratios (OR) were used to analyze associations. Among workers with PS, X² = 0.73 (p = 0.391) and 1.11 (p = 0.292) were reported, and among those without PS, X² = 0.86 (p = 0.354) and 1.24 (p = 0.265), for the years 2022 and 2023, respectively. Therefore, there was no significant association between workers with or without PS and an elevated WHtR, both in those younger than and older than 40 years of age. Advanced age (≥40 years) showed a significant association with increased WHtR (p < 0.01; OR = 2.6). However, no statistical association was observed between PS and elevated WHtR (p > 0.05; OR = 1.15). These findings suggest that age plays a more prominent role than occupational PS time in WHtR among male workers. Future studies should consider other factors, including physical activity and dietary habits, that could affect WHtR.

Background: Aquatic therapy has emerged as a promising rehabilitation strategy for people with multiple sclerosis (MS), potentially improving physical and psychological outcomes through the unique properties of water. The aim of the study was to systematically evaluate the effects of aquatic therapy on fatigue, mobility, physical function, and quality of life (QoL) in people with MS. Methods: A systematic review and meta-analysis were conducted following PRISMA guidelines. Electronic databases (PubMed, Scopus, Web of Science, PEDro, CINAHL, and Cochrane) were searched from inception to February 2026. Eligible studies included adults with MS undergoing aquatic therapy interventions. Risk of bias and methodological quality was assessed using the Cochrane tool and the PEDro scale, respectively. Effect sizes were calculated as standardized mean differences (SMD) using a random-effects model. Results: Seven randomized controlled trials (RCTs) were included in the review. Meta-analysis demonstrated a large reduction in fatigue (SMD ≈ −1.20), moderate improvements in mobility and physical function (SMD ≈ 0.7), and small-to-moderate improvements in QoL (SMD ≈ 0.45) in favour of aquatic therapy. Heterogeneity ranged from moderate to high depending on the outcome. Qualitative synthesis supported these findings and indicated additional benefits in strength, balance, psychological well-being, and disease-related symptoms. No adverse events were reported. Conclusions: Aquatic therapy may represent a generally well-tolerated and potentially beneficial rehabilitation strategy for improving fatigue, mobility, and QoL in people with MS. However, these findings should be interpreted with caution due to the limited number of included RCTs, relatively small sample sizes, and substantial heterogeneity across interventions and outcome measures.