Uniform spraying by conventional plant protection drones often results in low herbicide utilization efficiency and environmental contamination, both of which are critical issues in agricultural production. To address these challenges, this study proposed a precision weed management system for maize fields that combines an improved YOLOv11n-OSAW detection model with DJI drones for variable-rate herbicide application. The YOLOv11n-OSAW model was enhanced with Omni-dimensional Dynamic Convolution (OD-Conv), the SEAM attention mechanism, a lightweight ADown module, and the Wise-IoU (WIoU) loss function, aiming to improve the detection accuracy of small and occluded weeds in maize fields. When the model was deployed on an uncrewed aerial vehicle (UAV) operating at 5 m altitude, it achieved mean Average Precision mAP@0.5 values of 97.8% and 97.0% for gramineous and broad-leaved weeds, respectively—representing increases of 2.9 and 1.6 percentage points over the baseline YOLOv11n model. Weed distribution maps generated from the detection results were used to develop site-specific herbicide prescription maps, guiding the drone to implement targeted spraying. Water-sensitive paper analysis verified that the system ensured effective droplet deposition and uniform coverage across different application rate areas. This integrated workflow, covering UAV image acquisition, weed detection, variable-rate application, and effect assessment, reduced herbicide consumption by 20.25% compared with conventional uniform spraying (450 L/ha) while maintaining excellent weed control efficiency and reducing environmental risks. The findings demonstrate that the proposed system provides a practical and sustainable solution for weed management in maize fields.