This article describes the preparation of thermal interface materials (TIMs) based on silver microparticles and gold nanoparticles, fabricated via low-temperature sintering, and evaluates their mechanical and thermal properties. The characterization involved several techniques, including shear strength testing, metallographic analysis, and thermal resistance measurements. A comparative analysis of the key material properties, namely thermal and mechanical performance, was conducted. The results identify the 2:1 LC formulation—comprising silver microparticles, gold nanoparticles, glycol, and ethanol at a weight ratio of 2:0.01:7:5—as the most effective among the tested TIMs. Furthermore, a positive correlation between increased sintering temperature and enhanced mechanical properties was observed.