The alarming rates and pervasiveness of suicidal and self‐destructive behaviors (e.g., non‐suicidal self‐injury) among young sexual minorities represent a major public health concern. We set out to examine whether an empirically driven treatment for suicide and self‐harm, dialectical behavior therapy for adolescents (DBT‐A), provides benefits for adolescents who identify as gay, lesbian, bisexual, or questioning (LGBQ). LGBQ adolescents (n = 16) were compared with non‐LGBQ peers (n = 23). Psychological measures were collected before and after participation in a comprehensive DBT‐A program. LGBQ participants demonstrated significant improvements in emotion regulation, depression, borderline symptoms, and coping strategies; changes were comparable to their heterosexual peers.