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Vitamin D (VD) is essential for bone homeostasis, but it is also involved in pleiotropic effects on various organs and tissues. In adults, VD deficiency can cause or exacerbate osteoporosis and induce osteomalacia. However, every tissue and cell in the body has a VD receptor, including the brain, heart, stomach, pancreas, skin, gonads, and immune cells, and a deficiency may modify the function of these organs. Thus, the wide-ranging actions of VD help to explain why a reduction in VD amount has been correlated with numerous chronic diseases. In fact, VD deficiency increases the risk of osteoporosis and several other diseases and complications characterized by impaired bone metabolisms, such as autoimmune diseases, inflammatory bowel diseases, allergy, endocrinological diseases, hematological malignancies, and bone marrow transplantation. This review aims to investigate the link between VD deficiency, osteoporosis, and its concomitant diseases. Further epidemiological and mechanistic studies are necessary in order to ascertain the real role of hypovitaminosis in causing the reported diseases; however, adequate vitamin supplementation and restoration of metabolic normality could be useful for better management of these pathologies.
Massimo De Martinis; Alessandro Allegra; Maria Maddalena Sirufo; Alessandro Tonacci; Giovanni Pioggia; Martina Raggiunti; Lia Ginaldi; Sebastiano Gangemi. Vitamin D Deficiency, Osteoporosis and Effect on Autoimmune Diseases and Hematopoiesis: A Review. International Journal of Molecular Sciences 2021, 22, 8855 .
AMA StyleMassimo De Martinis, Alessandro Allegra, Maria Maddalena Sirufo, Alessandro Tonacci, Giovanni Pioggia, Martina Raggiunti, Lia Ginaldi, Sebastiano Gangemi. Vitamin D Deficiency, Osteoporosis and Effect on Autoimmune Diseases and Hematopoiesis: A Review. International Journal of Molecular Sciences. 2021; 22 (16):8855.
Chicago/Turabian StyleMassimo De Martinis; Alessandro Allegra; Maria Maddalena Sirufo; Alessandro Tonacci; Giovanni Pioggia; Martina Raggiunti; Lia Ginaldi; Sebastiano Gangemi. 2021. "Vitamin D Deficiency, Osteoporosis and Effect on Autoimmune Diseases and Hematopoiesis: A Review." International Journal of Molecular Sciences 22, no. 16: 8855.
Maria Maddalena Sirufo; Lia Ginaldi; Massimo De Martinis. Gut microbiota-microRNA interactions in osteoarthritis. Gene 2021, 803, 145887 .
AMA StyleMaria Maddalena Sirufo, Lia Ginaldi, Massimo De Martinis. Gut microbiota-microRNA interactions in osteoarthritis. Gene. 2021; 803 ():145887.
Chicago/Turabian StyleMaria Maddalena Sirufo; Lia Ginaldi; Massimo De Martinis. 2021. "Gut microbiota-microRNA interactions in osteoarthritis." Gene 803, no. : 145887.
Maria Maddalena Sirufo; Lia Ginaldi; Massimo De Martinis. Microbiota-miRNA interactions: Opportunities in ankylosing spondylitis. Autoimmunity Reviews 2021, 20, 102905 .
AMA StyleMaria Maddalena Sirufo, Lia Ginaldi, Massimo De Martinis. Microbiota-miRNA interactions: Opportunities in ankylosing spondylitis. Autoimmunity Reviews. 2021; 20 (10):102905.
Chicago/Turabian StyleMaria Maddalena Sirufo; Lia Ginaldi; Massimo De Martinis. 2021. "Microbiota-miRNA interactions: Opportunities in ankylosing spondylitis." Autoimmunity Reviews 20, no. 10: 102905.
We read with great interest the article by J Wei et al. “Association between gut microbiota and symptomatic hand osteoarthritis: data from the Xiangya Osteoarthritis Study” recently published in the Journal and shedding light on the association between gut microbiome and the presence of symptomatic hand osteoarthritis (OA). Their findings help understand the role of microbiome in the development of SHOA and [1] could became the target of emerging therapies [2].
Maddalena Sirufo; Lia Ginaldi; Massimo De Martinis. Non–coding RNAs, osteoarthritis and the microbiome: new therapeutic targets? Arthritis & Rheumatology 2021, 1 .
AMA StyleMaddalena Sirufo, Lia Ginaldi, Massimo De Martinis. Non–coding RNAs, osteoarthritis and the microbiome: new therapeutic targets? Arthritis & Rheumatology. 2021; ():1.
Chicago/Turabian StyleMaddalena Sirufo; Lia Ginaldi; Massimo De Martinis. 2021. "Non–coding RNAs, osteoarthritis and the microbiome: new therapeutic targets?" Arthritis & Rheumatology , no. : 1.
Immune, neuroendocrine, and autonomic nervous system dysregulation in anorexia nervosa lead to cardiovascular complications that can potentially result in increased morbidity and mortality. It is suggested that a complex non-invasive assessment of cardiovascular autonomic regulation—cardiac vagal control, sympathetic vascular activity, and cardiovascular reflex control—could represent a promising tool for early diagnosis, personalized therapy, and monitoring of therapeutic interventions in anorexia nervosa particularly at a vulnerable adolescent age. In this view, we recommend to consider in the diagnostic route, at least in the subset of patients with peripheral microvascular symptoms, a nailfold video-capillaroscopy as an easy not invasive tool for the early assessing of possible cardiovascular involvement.
Maria Sirufo; Lia Ginaldi; Massimo De Martinis. Peripheral Vascular Abnormalities in Anorexia Nervosa: A Psycho-Neuro-Immune-Metabolic Connection. International Journal of Molecular Sciences 2021, 22, 5043 .
AMA StyleMaria Sirufo, Lia Ginaldi, Massimo De Martinis. Peripheral Vascular Abnormalities in Anorexia Nervosa: A Psycho-Neuro-Immune-Metabolic Connection. International Journal of Molecular Sciences. 2021; 22 (9):5043.
Chicago/Turabian StyleMaria Sirufo; Lia Ginaldi; Massimo De Martinis. 2021. "Peripheral Vascular Abnormalities in Anorexia Nervosa: A Psycho-Neuro-Immune-Metabolic Connection." International Journal of Molecular Sciences 22, no. 9: 5043.
Vitamin D is a steroid hormone that is essential for bone mineral metabolism and it has several other effects in the body, including anti-cancer actions. Vitamin D causes a reduction in cell growth by interrupting the cell cycle. Moreover, the active form of vitamin D, i.e., 1,25-dihydroxyvitamin D, exerts various effects via its interaction with the vitamin D receptor on the innate and adaptive immune system, which could be relevant in the onset of tumors. Multiple myeloma is a treatable but incurable malignancy characterized by the growth of clonal plasma cells in protective niches in the bone marrow. In patients affected by multiple myeloma, vitamin D deficiency is commonly correlated with an advanced stage of the disease, greater risk of progression, the development of pathological fractures, and a worse prognosis. Changes in the vitamin D receptor often contribute to the occurrence and progress of deficiencies, which can be overcome by supplementation with vitamin D or analogues. However, in spite of the findings available in the literature, there is no clear standard of care and clinical practice varies. Further research is needed to better understand how vitamin D influences outcomes in patients with monoclonal gammopathies.
Vanessa Innao; Alessandro Allegra; Lia Ginaldi; Giovanni Pioggia; Massimo De Martinis; Caterina Musolino; Sebastiano Gangemi. Reviewing the Significance of Vitamin D Substitution in Monoclonal Gammopathies. International Journal of Molecular Sciences 2021, 22, 4922 .
AMA StyleVanessa Innao, Alessandro Allegra, Lia Ginaldi, Giovanni Pioggia, Massimo De Martinis, Caterina Musolino, Sebastiano Gangemi. Reviewing the Significance of Vitamin D Substitution in Monoclonal Gammopathies. International Journal of Molecular Sciences. 2021; 22 (9):4922.
Chicago/Turabian StyleVanessa Innao; Alessandro Allegra; Lia Ginaldi; Giovanni Pioggia; Massimo De Martinis; Caterina Musolino; Sebastiano Gangemi. 2021. "Reviewing the Significance of Vitamin D Substitution in Monoclonal Gammopathies." International Journal of Molecular Sciences 22, no. 9: 4922.
Maria Maddalena Sirufo; Lia Ginaldi; Massimo De Martinis. The IL-33/ST2 axis and vitamin D as a possible emerging therapeutic target in osteoarthritis. Rheumatology 2021, 1 .
AMA StyleMaria Maddalena Sirufo, Lia Ginaldi, Massimo De Martinis. The IL-33/ST2 axis and vitamin D as a possible emerging therapeutic target in osteoarthritis. Rheumatology. 2021; ():1.
Chicago/Turabian StyleMaria Maddalena Sirufo; Lia Ginaldi; Massimo De Martinis. 2021. "The IL-33/ST2 axis and vitamin D as a possible emerging therapeutic target in osteoarthritis." Rheumatology , no. : 1.
M.M. Sirufo; L. Ginaldi; M. De Martinis. Bone health in men: still suffer the gender gap. Osteoporosis International 2021, 1 -1.
AMA StyleM.M. Sirufo, L. Ginaldi, M. De Martinis. Bone health in men: still suffer the gender gap. Osteoporosis International. 2021; ():1-1.
Chicago/Turabian StyleM.M. Sirufo; L. Ginaldi; M. De Martinis. 2021. "Bone health in men: still suffer the gender gap." Osteoporosis International , no. : 1-1.
We report the case of a 49-year-old woman diagnosed with a rare histotype of early breast cancer (BC), invasive ductal carcinoma with osteoclast-like giant cells (OGCs), from the perspective of gene profile analysis tests. The patient underwent a quadrantectomy of the right breast with removal of 2 cm neoplastic nodule and three ipsilateral sentinel lymph nodes. The Oncotype Dx gave a recurrence score (RS) of 23, and taking into account the patient’s age, an RS of 23 corresponds to a chemotherapy benefit of 6.5%. After a multidisciplinary collegial discussion, and in consideration of the patient’s age, the absence of comorbidity, the premenopausal state, the rare histotype and the Oncotype Dx report, the patient was offered adjuvant chemotherapy treatment followed by hormone therapy. This case may be an example of the utility of integrating gene expression profiling tests into clinical practice in the adjuvant treatment decision of a rare histotype BC. The Oncotype Dx test required to supplement the histological examination made us opt for the proposal of a combined treatment of adjuvant chemotherapy followed by adjuvant hormone therapy. It demonstrates the importance of considering molecular tests and, in particular, the Oncotype Dx, in estimating the risk of disease recovery at 10 years in order to identify patients who benefit from hormone therapy alone versus those who benefit from the addition of chemotherapy, all with a view toward patient-centered oncology. Here, we discuss the possible validity and limitations of the Oncotype Dx in a rare luminal A-like histotype with high infiltrate of stromal/inflammatory cells.
Azzurra Irelli; Maria Sirufo; Gina Quaglione; Francesca De Pietro; Enrica Bassino; Carlo D’Ugo; Lia Ginaldi; Massimo De Martinis. Invasive Ductal Breast Cancer with Osteoclast-Like Giant Cells: A Case Report Based on the Gene Expression Profile for Changes in Management. Journal of Personalized Medicine 2021, 11, 156 .
AMA StyleAzzurra Irelli, Maria Sirufo, Gina Quaglione, Francesca De Pietro, Enrica Bassino, Carlo D’Ugo, Lia Ginaldi, Massimo De Martinis. Invasive Ductal Breast Cancer with Osteoclast-Like Giant Cells: A Case Report Based on the Gene Expression Profile for Changes in Management. Journal of Personalized Medicine. 2021; 11 (2):156.
Chicago/Turabian StyleAzzurra Irelli; Maria Sirufo; Gina Quaglione; Francesca De Pietro; Enrica Bassino; Carlo D’Ugo; Lia Ginaldi; Massimo De Martinis. 2021. "Invasive Ductal Breast Cancer with Osteoclast-Like Giant Cells: A Case Report Based on the Gene Expression Profile for Changes in Management." Journal of Personalized Medicine 11, no. 2: 156.
Patients with psoriasis (Pso) and, in particular, psoriatic arthritis (PsoA) have an increased risk of developing osteoporosis (OP). It has been shown that OP is among the more common pathologies associated with Pso, mainly due to the well-known osteopenizing conditions coexisting in these patients. Pso and OP share common risk factors, such as vitamin D deficiency and chronic inflammation. Interestingly, the interleukin (IL)-33/ST2 axis, together with vitamin D, is closely related to both Pso and OP. Vitamin D and the IL-33/ST2 signaling pathways are closely involved in bone remodeling, as well as in skin barrier pathophysiology. The production of anti-osteoclastogenic cytokines, e.g., IL-4 and IL-10, is promoted by IL-33 and vitamin D, which are stimulators of both regulatory and Th2 cells. IL-33, together with other Th2 cytokines, shifts osteoclast precursor differentiation towards macrophage and dendritic cells and inhibits receptor activator of nuclear factor kappa-B ligand (RANKL)-induced osteoclastogenesis by regulating the expression of anti-osteoclastic genes. However, while the vitamin D protective functions in OP and Pso have been definitively ascertained, the overall effect of IL-33 on bone and skin homeostasis, because of its pleiotropic action, is still controversial. Emerging evidence suggests a functional link between vitamin D and the IL-33/ST2 axis, which acts through hormonal influences and immune-mediated effects, as well as cellular and metabolic functions. Based on the actions of vitamin D and IL-33 in Pso and OP, here, we hypothesize the role of their crosstalk in the pathogenesis of both these pathologies.
Massimo De Martinis; Lia Ginaldi; Maria Maddalena Sirufo; Enrica Maria Bassino; Francesca De Pietro; Giovanni Pioggia; Sebastiano Gangemi. IL-33/Vitamin D Crosstalk in Psoriasis-Associated Osteoporosis. Frontiers in Immunology 2021, 11, 1 .
AMA StyleMassimo De Martinis, Lia Ginaldi, Maria Maddalena Sirufo, Enrica Maria Bassino, Francesca De Pietro, Giovanni Pioggia, Sebastiano Gangemi. IL-33/Vitamin D Crosstalk in Psoriasis-Associated Osteoporosis. Frontiers in Immunology. 2021; 11 ():1.
Chicago/Turabian StyleMassimo De Martinis; Lia Ginaldi; Maria Maddalena Sirufo; Enrica Maria Bassino; Francesca De Pietro; Giovanni Pioggia; Sebastiano Gangemi. 2021. "IL-33/Vitamin D Crosstalk in Psoriasis-Associated Osteoporosis." Frontiers in Immunology 11, no. : 1.
Maria Maddalena Sirufo; Lia Ginaldi; Massimo De Martinis. Bone Health Risks Associated with Finasteride and Dutasteride Long-Term Use. The World Journal of Men's Health 2021, 39, 389 -390.
AMA StyleMaria Maddalena Sirufo, Lia Ginaldi, Massimo De Martinis. Bone Health Risks Associated with Finasteride and Dutasteride Long-Term Use. The World Journal of Men's Health. 2021; 39 (2):389-390.
Chicago/Turabian StyleMaria Maddalena Sirufo; Lia Ginaldi; Massimo De Martinis. 2021. "Bone Health Risks Associated with Finasteride and Dutasteride Long-Term Use." The World Journal of Men's Health 39, no. 2: 389-390.
Maria Maddalena Sirufo; Lia Ginaldi; Massimo De Martinis. MicroRNAs, bone and microbiota. Bone 2020, 144, 115824 .
AMA StyleMaria Maddalena Sirufo, Lia Ginaldi, Massimo De Martinis. MicroRNAs, bone and microbiota. Bone. 2020; 144 ():115824.
Chicago/Turabian StyleMaria Maddalena Sirufo; Lia Ginaldi; Massimo De Martinis. 2020. "MicroRNAs, bone and microbiota." Bone 144, no. : 115824.
M.M. Sirufo; E.M. Bassino; F. De Pietro; L. Ginaldi; M. De Martinis. Nailfold capillaroscopy: Clinical practice in non-rheumatic conditions. Microvascular Research 2020, 134, 104122 .
AMA StyleM.M. Sirufo, E.M. Bassino, F. De Pietro, L. Ginaldi, M. De Martinis. Nailfold capillaroscopy: Clinical practice in non-rheumatic conditions. Microvascular Research. 2020; 134 ():104122.
Chicago/Turabian StyleM.M. Sirufo; E.M. Bassino; F. De Pietro; L. Ginaldi; M. De Martinis. 2020. "Nailfold capillaroscopy: Clinical practice in non-rheumatic conditions." Microvascular Research 134, no. : 104122.
Hundreds of trillions of bacteria are present in the human body in a mutually beneficial symbiotic relationship with the host. A stable dynamic equilibrium exists in healthy individuals between the microbiota, host organism, and environment. Imbalances of the intestinal microbiota contribute to the determinism of various diseases. Recent research suggests that the microbiota is also involved in the regulation of the bone metabolism, and its alteration may induce osteoporosis. Due to modern molecular biotechnology, various mechanisms regulating the relationship between bone and microbiota are emerging. Understanding the role of microbiota imbalances in the development of osteoporosis is essential for the development of potential osteoporosis prevention and treatment strategies through microbiota targeting. A relevant complementary mechanism could be also constituted by the permanent relationships occurring between microbiota and microRNAs (miRNAs). miRNAs are a set of small non-coding RNAs able to regulate gene expression. In this review, we recapitulate the physiological and pathological meanings of the microbiota on osteoporosis onset by governing miRNA production. An improved comprehension of the relations between microbiota and miRNAs could furnish novel markers for the identification and monitoring of osteoporosis, and this appears to be an encouraging method for antagomir-guided tactics as therapeutic agents.
Massimo De Martinis; Lia Ginaldi; Alessandro Allegra; Maria Maddalena Sirufo; Giovanni Pioggia; Alessandro Tonacci; Sebastiano Gangemi. The Osteoporosis/Microbiota Linkage: The Role of miRNA. International Journal of Molecular Sciences 2020, 21, 8887 .
AMA StyleMassimo De Martinis, Lia Ginaldi, Alessandro Allegra, Maria Maddalena Sirufo, Giovanni Pioggia, Alessandro Tonacci, Sebastiano Gangemi. The Osteoporosis/Microbiota Linkage: The Role of miRNA. International Journal of Molecular Sciences. 2020; 21 (23):8887.
Chicago/Turabian StyleMassimo De Martinis; Lia Ginaldi; Alessandro Allegra; Maria Maddalena Sirufo; Giovanni Pioggia; Alessandro Tonacci; Sebastiano Gangemi. 2020. "The Osteoporosis/Microbiota Linkage: The Role of miRNA." International Journal of Molecular Sciences 21, no. 23: 8887.
Osteoporosis is a skeletal pathology characterized by compromised bone strength leading to increased risk of fracture, mainly the spine and hip fractures. Osteoporosis affects more than 200 million people worldwide and because of the skeletal fractures it causes, represents a major cause of morbidity, disability and mortality in older people. Recently, the new discoveries of osteoimmunology have clarified many of the pathogenetic mechanisms of osteoporosis, helping to identify new immunological targets for its treatment opening the way for new and effective therapies with biological drugs. Currently, there are basically two monoclonal antibodies for osteoporosis therapy: denosumab and romosozumab. Here, we focus on the modern approach to the osteoporosis management and in particular, on current and developing biologic drugs targeted to new immunological checkpoints, in the landscape of osteoimmunology.
Massimo De Martinis; Maria Maddalena Sirufo; Lia Ginaldi. Osteoporosis: Current and Emerging Therapies Targeted to Immunological Checkpoints. Current Medicinal Chemistry 2020, 27, 6356 -6372.
AMA StyleMassimo De Martinis, Maria Maddalena Sirufo, Lia Ginaldi. Osteoporosis: Current and Emerging Therapies Targeted to Immunological Checkpoints. Current Medicinal Chemistry. 2020; 27 (37):6356-6372.
Chicago/Turabian StyleMassimo De Martinis; Maria Maddalena Sirufo; Lia Ginaldi. 2020. "Osteoporosis: Current and Emerging Therapies Targeted to Immunological Checkpoints." Current Medicinal Chemistry 27, no. 37: 6356-6372.
Background and objectives: Electrocardiograph abnormalities (i.e., QT interval prolongation) have been described in inflammatory bowel diseases (IBD). We aimed to measure the QT interval in a cohort of patients with IBD and to analyze its relationship with clinical and inflammatory activity. Materials and Methods: We performed a cross-sectional study that included 38 IBD outpatients and 38 “age- and sex-matched” healthy controls. Nine patients had active IBD, and 29 were in clinical remission. Among the latter, 10 patients had sustained (lasting >1 year) and 19 had short-term remission (≤1 year). Corrected QT (QTc) interval was measured on standard 12-lead electrocardiograph. A systematic review of the literature on studies investigating the QT interval in patients with IBD was also performed. Results: QTc interval values were similar between IBD patients and healthy controls (417.58 ± 22.05 ms vs. 409.13 ± 19.61 ms, respectively; p: 0.479). Patients with active IBD had significantly higher QTc values (435.11 ± 27.31 ms) than both controls (409.13 ± 19.61 ms) and patients in remission (412.14 ± 17.33 ms) (p: 0.031). Post hoc analysis showed that the difference in QTc values between active IBD and remission was attributable to the group of patients with sustained remission (p < 0.05). Lastly, a significant correlation between QTc interval and C-reactive protein (CRP) values was observed (Spearman test: r = 0.563; p: 0.0005). Conclusions: Our study demonstrates an association between QTc duration and both clinical and inflammatory activity in patients with IBD. The higher the CRP value, the longer is the QTc duration. For practical purposes, all patients with active IBD should undergo a standard ECG. Prescription of drugs able to modify the QT interval should be avoided in patients with active IBD. The systematic review of the literature indicated that this is the first published study demonstrating an association between the QTc duration and CRP values in patients with IBD.
Angelo Viscido; Annalisa Capannolo; Renata Petroni; Gianpiero Stefanelli; Giulia Zerboni; Massimo De Martinis; Stefano Necozione; Maria Penco; Giuseppe Frieri; Giovanni Latella; Silvio Romano. Association between Corrected QT Interval and C-Reactive Protein in Patients with Inflammatory Bowel Diseases. Medicina 2020, 56, 382 .
AMA StyleAngelo Viscido, Annalisa Capannolo, Renata Petroni, Gianpiero Stefanelli, Giulia Zerboni, Massimo De Martinis, Stefano Necozione, Maria Penco, Giuseppe Frieri, Giovanni Latella, Silvio Romano. Association between Corrected QT Interval and C-Reactive Protein in Patients with Inflammatory Bowel Diseases. Medicina. 2020; 56 (8):382.
Chicago/Turabian StyleAngelo Viscido; Annalisa Capannolo; Renata Petroni; Gianpiero Stefanelli; Giulia Zerboni; Massimo De Martinis; Stefano Necozione; Maria Penco; Giuseppe Frieri; Giovanni Latella; Silvio Romano. 2020. "Association between Corrected QT Interval and C-Reactive Protein in Patients with Inflammatory Bowel Diseases." Medicina 56, no. 8: 382.
The global burden of cancer is growing and a wide disparity in the incidence, malignancy and mortality of different types of cancer between each sex has been demonstrated. The sex specificity of cancer appears to be a relevant issue in the management of the disease, and studies investigating the role of sex and gender are becoming extremely urgent. Sex hormones are presumably the leading actors of sex differences in cancer, especially estrogens. They modulate gene expression, alter molecules and generate disparities in effectiveness and side effects of anticancer therapies. Recently immunotherapy aims to improve anticancer treatment strategies reducing off-target effects of chemotherapy and direct cancer cells killing. It is recognized as a fruitful strategy to treat and possible to cure cancer. Immunotherapeutic agents are used to activate or boost the activation of the immune system to fight cancer cells through physiological mechanisms often evaded in the offensive march of the disease. These therapeutic strategies have allowed new successes, but also have serious adverse effects including non-specific inflammation and autoimmunity. Sex and gender issues are of primary importance in this field, due to their recognized role in inflammation, immunity and cancer, and the clarification and understanding of these aspects is a necessary step to increase the responses and to diminish the adverse effects of immunotherapy. This review describes the available knowledge on the role of sex and gender in cancer immunotherapy, and will offer insights to stimulate the attention and practice of clinicians and researchers in a gender perspective of new cancer treatment strategies.
Azzurra Irelli; Maria Maddalena Sirufo; Carlo D’Ugo; Lia Ginaldi; Massimo De Martinis. Sex and Gender Influences on Cancer Immunotherapy Response. Biomedicines 2020, 8, 232 .
AMA StyleAzzurra Irelli, Maria Maddalena Sirufo, Carlo D’Ugo, Lia Ginaldi, Massimo De Martinis. Sex and Gender Influences on Cancer Immunotherapy Response. Biomedicines. 2020; 8 (7):232.
Chicago/Turabian StyleAzzurra Irelli; Maria Maddalena Sirufo; Carlo D’Ugo; Lia Ginaldi; Massimo De Martinis. 2020. "Sex and Gender Influences on Cancer Immunotherapy Response." Biomedicines 8, no. 7: 232.
Osteoporosis (OP) is defined as a generalized skeletal disease characterized by low bone mass and an alteration of the microarchitecture that lead to an increase in bone fragility and, therefore, an increased risk of fractures. It must be considered today as a true public health problem and the most widespread metabolic bone disease that affects more than 200 million people worldwide. Under physiological conditions, there is a balance between bone formation and bone resorption necessary for skeletal homeostasis. In pathological situations, this balance is altered in favor of osteoclast (OC)-mediated bone resorption. During chronic inflammation, the balance between bone formation and bone resorption may be considerably affected, contributing to a net prevalence of osteoclastogenesis. Skin diseases are the fourth cause of human disease in the world, affecting approximately one third of the world’s population with a prevalence in elderly men. Inflammation and the various associated cytokine patterns are the basis of both osteoporosis and most skin pathologies. Moreover, dermatological patients also undergo local or systemic treatments with glucocorticoids and immunosuppressants that could increase the risk of osteoporosis. Therefore, particular attention should be paid to bone health in these patients. The purpose of the present review is to take stock of the knowledge in this still quite unexplored field, despite the frequency of such conditions in clinical practice.
Maria Maddalena Sirufo; Francesca De Pietro; Enrica Maria Bassino; Lia Ginaldi; Massimo De Martinis. Osteoporosis in Skin Diseases. International Journal of Molecular Sciences 2020, 21, 4749 .
AMA StyleMaria Maddalena Sirufo, Francesca De Pietro, Enrica Maria Bassino, Lia Ginaldi, Massimo De Martinis. Osteoporosis in Skin Diseases. International Journal of Molecular Sciences. 2020; 21 (13):4749.
Chicago/Turabian StyleMaria Maddalena Sirufo; Francesca De Pietro; Enrica Maria Bassino; Lia Ginaldi; Massimo De Martinis. 2020. "Osteoporosis in Skin Diseases." International Journal of Molecular Sciences 21, no. 13: 4749.
Osteoporosis is an age-related bone disease, affecting mainly postmenopausal women, characterized by decreased bone mineral density (BMD) and consequent risk of fractures. Homocysteine (Hcy), a sulfur-aminoacid whose serum level is regulated by methylenetrahydrofolate reductase (MTHFR) activity and vitamin B12 and folate as cofactors, is a risk factor for inflammatory diseases. Literature data concerning the link between Hcy and osteoporosis are still debated. The aim of our study was to assess the relationship among Hcy and BMD, inflammation, vitamin status and bone turnover in postmenopausal osteoporosis. In 252 postmenopausal women, BMD was measured by dual-energy X-ray absorptiometry (DXA). In addition to serum Hcy, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and bone turnover markers (bone alkaline phosphatase-BAP, osteocalcin-OC, C-terminal telopeptide of type I collagen (CTX), vitamin deficiencies and MTHFR-C677T polymorphism were evaluated. Hcy, inflammation, bone resorption markers and prevalence of C677T polymorphism were higher, whereas vitamin D, B12, folate, and bone formation markers were lower in women with decreased BMD compared to those with normal BMD. Our results suggest a significant association between Hcy, BMD and inflammation in postmenopausal osteoporosis. The regulation of Hcy overproduction and the modulation of the inflammatory substrate could represent additional therapeutic approaches for osteoporosis prevention.
Massimo De Martinis; Maria Maddalena Sirufo; Cristina Nocelli; Lara Fontanella; Lia Ginaldi. Hyperhomocysteinemia Is Associated with Inflammation, Bone Resorption, Vitamin B12 and Folate Deficiency and MTHFR C677T Polymorphism in Postmenopausal Women with Decreased Bone Mineral Density. International Journal of Environmental Research and Public Health 2020, 17, 4260 .
AMA StyleMassimo De Martinis, Maria Maddalena Sirufo, Cristina Nocelli, Lara Fontanella, Lia Ginaldi. Hyperhomocysteinemia Is Associated with Inflammation, Bone Resorption, Vitamin B12 and Folate Deficiency and MTHFR C677T Polymorphism in Postmenopausal Women with Decreased Bone Mineral Density. International Journal of Environmental Research and Public Health. 2020; 17 (12):4260.
Chicago/Turabian StyleMassimo De Martinis; Maria Maddalena Sirufo; Cristina Nocelli; Lara Fontanella; Lia Ginaldi. 2020. "Hyperhomocysteinemia Is Associated with Inflammation, Bone Resorption, Vitamin B12 and Folate Deficiency and MTHFR C677T Polymorphism in Postmenopausal Women with Decreased Bone Mineral Density." International Journal of Environmental Research and Public Health 17, no. 12: 4260.
Azzurra Irelli; Maria Maddalena Sirufo; Teresa Scipioni; Francesca De Pietro; Amedeo Pancotti; Lia Ginaldi; Massimo DE Martinis. Breast cancer patients receiving denosumab during adjuvant aromatase inhibitors treatment: who are the "inadequate responders" patients to denosumab? Journal of B.U.ON. : official journal of the Balkan Union of Oncology 2020, 25, 648 -654.
AMA StyleAzzurra Irelli, Maria Maddalena Sirufo, Teresa Scipioni, Francesca De Pietro, Amedeo Pancotti, Lia Ginaldi, Massimo DE Martinis. Breast cancer patients receiving denosumab during adjuvant aromatase inhibitors treatment: who are the "inadequate responders" patients to denosumab? Journal of B.U.ON. : official journal of the Balkan Union of Oncology. 2020; 25 (2):648-654.
Chicago/Turabian StyleAzzurra Irelli; Maria Maddalena Sirufo; Teresa Scipioni; Francesca De Pietro; Amedeo Pancotti; Lia Ginaldi; Massimo DE Martinis. 2020. "Breast cancer patients receiving denosumab during adjuvant aromatase inhibitors treatment: who are the "inadequate responders" patients to denosumab?" Journal of B.U.ON. : official journal of the Balkan Union of Oncology 25, no. 2: 648-654.