A computer-aided detection (CAD) system is helpful for radiologists to detect pulmonary nodules at an early stage. In this paper, we propose a novel pulmonary nodule detection method based on hierarchical block classification. The proposed CAD system consists of three steps. In the first step, input computed tomography images are split into three-dimensional block images, and we apply entropy analysis on the block images to select informative blocks. In the second step, the selected block images are segmented and adjusted for detecting nodule candidates. In the last step, we classify the nodule candidate images into nodules and non-nodules. We extract feature vectors of the objects in the selected blocks. Lastly, the support vector machine is applied to classify the extracted feature vectors. Performance of the proposed system is evaluated on the Lung Image Database Consortium database. The proposed method has reduced the false positives in the nodule candidates significantly. It achieved 95.28% sensitivity with only 2.27 false positives per scan.

Mostly, shape-from-focus algorithms use local averaging using a fixed rectangle window to enhance the initial focus volume. In this linear filtering, the window size affects the accuracy of the depth map. A small window is unable to suppress the noise properly, whereas a large window oversmoothes the object shape. Moreover, the use of any window size smoothes focus values uniformly. Consequently, an erroneous depth map is obtained. In this paper, we suggest the use of iterative 3-D anisotropic nonlinear diffusion filtering (ANDF) to enhance the image focus volume. In contrast to linear filtering, ANDF utilizes the local structure of the focus values to suppress the noise while preserving edges. The proposed scheme is tested using image sequences of synthetic and real objects, and results have demonstrated its effectiveness.