Background/Objectives: Breast cancer remains a major cause of cancer-related mortality among women worldwide, highlighting the need for new therapeutic strategies. Pyrimidine derivatives have shown promise in oncology due to their ability to modulate immune responses and influence tumor growth pathways. Methods: Cytotoxicity of Xymedon was evaluated using MTT and colony formation assays on cancer MCF-7, NCI-H322M, HCT-15 cells, and primary human foreskin fibroblasts. In vivo efficacy was assessed in an orthotopic MCF-7 xenograft model in female Balb/c nude mice. Xymedon was administered orally at 410 mg/kg daily alone or in combination with intraperitoneal doxorubicin (1 mg/kg weekly). Hematological, histological, and immunohistochemical analyses were performed. Results: In vitro, Xymedon (up to 3 mM) showed no cytotoxicity against cancer cell lines or human skin fibroblasts. In vivo, Xymedon significantly increased tumor necrosis (44.1% vs. 28.5%, p < 0.01) and enhanced intratumoral infiltration of CD3+, CD8+, and CD20+ lymphocytes, with peritumoral counts increasing 2.2–5.3-fold. It mitigated Doxorubicin-induced myelosuppression by improving red blood cell counts, hemoglobin, and hematocrit levels, while platelet recovery remained limited. Combination therapy with Xymedon did not affect tumor volume or weight, but resulted in a non-significant trend toward improved survival (80% vs. 30%, p ≈ 0.11; Hazard Ratio [HR] = 0.268, 95% CI: 0.07082 to 1.012) without affecting fibrous capsule formation. Conclusions: These results suggest that Xymedon is a non-cytotoxic immunomodulator with potential as an adjuvant to enhance antitumor immunity and reduce hematologic toxicity associated with chemotherapy. Further studies are needed to elucidate the molecular pathways and confirm clinical efficacy.

In modern veterinary practice, there is an acute problem of restoring the structure and function of damaged articular cartilage in animals, especially in one-hoofed animals. Cartilage tissue has a limited ability to regenerate due to the fact that it does not have blood and lymphatic vessels. With large defects, fibrous tissue or fibrous cartilage grows, which differ from hyaline cartilage in biochemical and biomechanical parameters. Subsequently, the cartilage undergoes degeneration, which in some cases may progress to osteoarthritic changes. Numerous studies have been conducted in the last few years in search of effective treatments. Among them is the use of mesenchymal stem cells (MSCs).The purpose of this work was to review the results of studies presented in the current literature on the topic of articular cartilage regeneration using mesenchymal stem cells.The search for original studies was carried out in the systems ResearchGate, PubMed, Liebertpub. Information about the properties of mesenchymal stem cells and the features of their use, the results of clinical studies, as well as the degree of knowledge and future prospects are given.MSCs have the ability to self-maintain and differentiate into various mesenchymal cell lines (osteoid, chondrogenic, adipogenic). They are involved in the growth and development, restoration and regeneration of mesenchymal tissues. Based on the properties of MSCs, they represent a potential source of cells to induce regeneration of the affected articular cartilage.Currently, MSC-based therapy is still in preclinical and 1 stage of research. Large-scale clinical trials are required to comprehensively assess the mechanism of action of MSCs, and subsequently address issues of its improvement.

A car accident is a type of injury that a patient receives as a result of a collision with a vehicle. This type of injury is a frequent occurrence in clinical practice, but despite this, careful monitoring of the condition of the wounds, the general condition of the patient, compliance with the rules of asepsis and antisepsis, and knowledge of how to use certain dressings is required. Dressings, with their proper use, contribute to the fastest possible healing of wounds without complications. The purpose of the study was to research the effect of various dressings on the wound surface in patients with scalped wounds. The object of the study was 10 animals with car injuries. The studies were carried out on the basis of the veterinary clinic of Dr. Sotnikov, in the intensive care unit. Evaluation of the nature of wound healing was carried out using daily visual examination, assessment of exudate from the wound, daily assessment of blood tests.