Dr. Ganna Petruk
Lund University, Department of Clinical Sciences, Division of Dermatology and Venereology
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Academic Career Length
12Years (2015-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
View All Publications1 January 2018 in Oxidative Medicine and Cellular Longevity
Journal Article
Ganna Petruk
Rita Del GiudiceMRMaria Manuela Rigano
Maria Manuela Rigano
Daria Maria MontiExposure to UV light triggers the rapid generation and accumulation of reactive oxygen species (ROS) in skin cells, with consequent increase in oxidative stress and thus in photoaging. Exogenous supplementation with dietary antioxidants and/or skin pretreatment with antioxidant‐based lotions before sun exposure might be a winning strategy against age‐related skin pathologies. In this context, plants produce many secondary metabolites to protect themselves from UV radiations and these compounds can also protect the skin from photoaging. Phenolic compounds, ascorbic acid and carotenoids, derived from different plant species, are able to protect the skin by preventing UV penetration, reducing inflammation and oxidative stress, and influencing several survival signalling pathways. In this review, we focus our attention on the double role of oxidants in cell metabolism and on environmental and xenobiotic agents involved in skin photoaging. Moreover, we discuss the protective role of dietary antioxidants from fruits and vegetables and report their antiaging properties related to the reduction of oxidative stress pathways.
1 December 2020 in Journal of Molecular Cell Biology
Journal Article
Ganna PetrukMPManoj Puthia
Manoj Puthia
JPJitka Petrlova
Jitka Petrlova
FSFirdaus Samsudin
Firdaus Samsudin
ASAnn-Charlotte Strömdahl
Ann-Charlotte Strömdahl
ASArtur Schmidtchen
Artur Schmidtchen +4
There is a link between high lipopolysaccharide (LPS) levels in the blood and the metabolic syndrome, and metabolic syndrome predisposes patients to severe COVID-19. Here, we define an interaction between SARS-CoV-2 spike (S) protein and LPS, leading to aggravated inflammation in vitro and in vivo. Native gel electrophoresis demonstrated that SARS-CoV-2 S protein binds to LPS. Microscale thermophoresis yielded a KD of ∼47 nM for the interaction. Computational modeling and all-atom molecular dynamics simulations further substantiated the experimental results, identifying a main LPS-binding site in SARS-CoV-2 S protein. S protein, when combined with low levels of LPS, boosted nuclear factor-kappa B (NF-κB) activation in monocytic THP-1 cells and cytokine responses in human blood and peripheral blood mononuclear cells, respectively. The in vitro inflammatory response was further validated by employing NF-κB reporter mice and in vivo bioimaging. Dynamic light scattering, transmission electron microscopy, and LPS-FITC analyses demonstrated that S protein modulated the aggregation state of LPS, providing a molecular explanation for the observed boosting effect. Taken together, our results provide an interesting molecular link between excessive inflammation during infection with SARS-CoV-2 and comorbidities involving increased levels of bacterial endotoxins.
Journal Article
ARAssunta Raiola
Assunta RaiolaAEAngela Errico
Angela ErricoGanna PetrukDaria Maria MontiABAmalia Baone
Amalia BaoneMRMaria Manuela Rigano
Maria Manuela RiganoThe beneficial role of the Mediterranean diet in the prevention of chronic diseases, including cardiovascular diseases, diabetes, and obesity, is well-recognized. In this context, Brassicaceae are considered important vegetables due to several evidences of their health promoting effects that are associated to bioactive compounds present in the edible parts of the plants. In this review, the mechanisms of action and the factors regulating the levels of the bioactive compounds in Brassicaceae have been discussed. In addition, the impact of industrial and domestic processing on the amount of these compounds have been considered, in order to identify the best conditions that are able to preserve the functional properties of the Brassicaceae products before consumption. Finally, the main strategies used to increase the content of health-promoting metabolites in Brassica plants through biofortification have been analyzed.
1 February 2018 in Journal of Functional Foods
Journal Article
MSMansour Sobeh
Mansour SobehAEAhmed Esmat
Ahmed Esmat
Ganna PetrukMAMohamed A.O. Abdelfattah
Mohamed A.O. Abdelfattah
MDMalak Dmirieh
Malak Dmirieh
Michael Wink +2
1 August 2019 in Journal of Ethnopharmacology
Journal Article
MSMansour Sobeh
Mansour SobehMEMohamed El-Raey
Mohamed El-Raey
SRSamar Rezq
Samar RezqMAMohamed A.O. Abdelfattah
Mohamed A.O. Abdelfattah
Ganna PetrukMichael Wink +4
1 March 2018 in Food and Chemical Toxicology
Journal Article
MSMansour Sobeh
Mansour SobehFYFadia S. Youssef
Fadia S. Youssef
AEAhmed Esmat
Ahmed Esmat
Ganna PetrukAEAhmed H. El-Khatib
Ahmed H. El-Khatib
Michael Wink +2
About Me
Dr. Ganna Petruk has a research background in toxicology, drug discovery and biochemistry, specialising in living
models for in vitro and in vivo screening of antioxidants and anticancer agents. Ganna obtained her MSc in Molecular
and Industrial Biotechnology cum Laude in 2014 in Naples (Italy), working on the elucidation of the molecular bases
of Apolipoprotein A-I associated systemic amyloidosis. She received her PhD in Biotechnology in 2018 from the
University of Naples “Federico II” (UNINA, Italy). During her PhD, she characterized natural extracts with
antioxidant activity on eukaryotic cells models for cosmetic and food industry, working with Dr. Daria Maria Monti.
Ganna visited Prof. Michael Wink’s group at the Institute of Pharmacy and Molecular Biotechnology (Heidelberg
University, Germany), where she tested the extracts on an in vivo system, i.e. Caenorhabditis elegans, to define a
possible mechanism of action that confers the antioxidant activity to the extracts. In addition, she contributed to work
on the development of drug delivery systems for cancer therapy in collaboration with Prof. Antonello Merlino and
Prof. Francesco Ruffo at the Department of Chemical Sciences (UNINA). Ganna was awarded a tutoring position in
inorganic chemistry for Bachelor students with UNINA. Since January 2019 Ganna is a post-doc in Schmidtchen´s
group (Lund University, Sweden) working on endogenous antimicrobial and immunomodulatory peptides and proteins.