A piezoelectric actuator using a lever mechanism is designed, fabricated, and tested with the aim of accomplishing long-travel precision linear driving based on the stick-slip principle. The proposed actuator mainly consists of a stator, an adjustment mechanism, a preload mechanism, a base, and a linear guide. The stator design, comprising a piezoelectric stack and a lever mechanism with a long hinge used to increase the displacement of the driving foot, is described. A simplified model of the stator is created. Its design parameters are determined by an analytical model and confirmed using the finite element method. In a series of experiments, a laser displacement sensor is employed to measure the displacement responses of the actuator under the application of different driving signals. The experiment results demonstrate that the velocity of the actuator rises from 0.05 mm/s to 1.8 mm/s with the frequency increasing from 30 Hz to 150 Hz and the voltage increasing from 30 V to 150 V. It is shown that the minimum step distance of the actuator is 0.875 μm. The proposed actuator features large stroke, a simple structure, fast response, and high resolution.

Piezoelectric actuators with a flexible displacement amplification structure are widely used in the fields of precision driving and positioning. The displacement curve of conventional piezoelectric actuators is asymmetrical and non-linear, which leads to large non-linear errors and reduced positioning accuracy of these piezoelectric actuators. In this paper, a bidirectional active drive piezoelectric actuator is proposed, which suppresses the hysteresis phenomenon to a certain extent and reduces the non-linear error. Based on the deformation theory of the beam, a theoretical model of the rhombus mechanism was established, and the key parameters affecting the drive performance were analyzed. Then, the static and dynamic characteristics of series piezoelectric actuators were analyzed by the finite element method. A prototype was manufactured and the output performance was tested. The results show that the actuator can achieve a bidirectional symmetric output of amplification displacement, with a maximum value of 91.45 μm and a resolution of 35 nm. In addition, compared with the hysteresis loop of the piezoelectric stack, the nonlinear error is reduced by 62.94%.

Imitating the structure of the venous valve and its characteristics of passive opening and closing with changes in heart pressure, a piezoelectric pump with flexible valves (PPFV) was designed. Firstly, the structure and the working principle of the PPFV were introduced. Then, the flexible valve, the main functional component of the pump, was analyzed theoretically. Finally, an experimental prototype was manufactured and its performance was tested. The research proves that the PPFV can achieve a smooth transition between valved and valveless by only changing the driving signal of the piezoelectric (PZT) vibrator. The results demonstrate that when the driving voltage is 100 V and the frequency is 25 Hz, the experimental flow rate of the PPFV is about 119.61 mL/min, and the output pressure is about 6.16 kPa. This kind of pump can realize the reciprocal conversion of a large flow rate, high output pressure, and a small flow rate, low output pressure under the electronic control signal. Therefore, it can be utilized for fluid transport and pressure transmission at both the macro-level and the micro-level, which belongs to the macro–micro combined component.

Objective: Long noncoding RNA nuclear enriched abundant transcript 1 (lnc‐NEAT1) and its target microRNA‐125a (miR‐125a) are reported to regulate immune and inflammation process in allergic rhinitis (AR). Hence, this study intended to investigate the correlation between lnc‐NEAT1 and miR‐125a expressions, as well as their clinical values in pediatric AR patients.Methods: Peripheral blood mononuclear cell samples from 80 pediatric AR patients, 40 disease controls (DCs), and 40 healthy controls (HCs) were collected to detect lnc‐NEAT1 and miR‐125a expressions by reverse transcription‐quantitative polymerase chain reaction. For pediatric AR patients only, serum interferon‐gamma (IFN‐γ) and interleukin (IL)‐10 were measured by enzyme linked immunosorbent assay; meanwhile, T helper (Th) 1 and Th2 cells in CD4⁺ T cells were analyzed by flow cytometry.Results: Lnc‐NEAT1 was overexpressed, while miR‐125a downregulated in pediatric AR patients compared to DCs and HCs (all p < 0.001). Moreover, lnc‐NEAT1 expression negatively correlated with miR‐125a expression in pediatric AR patients (p = 0.002), but not in DCs (p = 0.226) or HCs (p = 0.237). Furthermore, in pediatric AR patients, lnc‐NEAT1 expression positively associated with TNSS (p < 0.001), sneezing score (p = 0.006), and congestion score (p = 0.008); miR‐125a expression was negatively related to TNSS (p < 0.001), itching score (p = 0.040), and sneezing score (p = 0.005). Additionally, lnc‐NEAT1 expression positively, while miR‐125a expression negatively correlated with Th2 cells and IL‐10 (all p < 0.05), but they were not correlated with Th1 cells or IFN‐γ in pediatric AR patients.Conclusion: Circulating lnc‐NEAT1 and miR‐125a are aberrantly expressed and linked with Th2 cells and symptom severity in pediatric allergic rhinitis.

Piezoelectric actuators based on bridge displacement amplifying mechanisms are widely used in precision driving and positioning fields. The classical bridge mechanism relies on structural flexibility to realize the return stroke, which leads to the low positioning accuracy of the actuator. In this paper, a series bridge mechanism is proposed to realize a bidirectional active drive; the return stroke is driven by a piezoelectric stack rather than by the flexibility of the structure. By analyzing the parameter sensitivity of the bridge mechanism, the series actuation of the bridge mechanism is optimized and the static and dynamic solutions are carried out by using the finite element method. Compared with the hysteresis loop of the piezoelectric stack, the displacement curve of the proposed actuator is symmetric, and the maximum nonlinear error is improved. The experimental results show that the maximum driving stroke of the actuator is 129.41 μm, and the maximum nonlinear error is 5.48%.