Clifton J Holmes

Dr. Clifton J Holmes

orcid

Research Focus & Metrics

Academic Career Length

9Years (2018-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

View All Publications
22 July 2021 in Nutrients
Verified
Journal Article
Open access
PDF file
CHClifton J Holmes
Clifton J Holmes
Susan Beth RacetteSusan Beth Racette
Susan Beth Racette
Body composition is a key component for maintaining good general health and longevity. It can be influenced by a variety of factors, including genetics, environment, and lifestyle choices. The assessment of body composition is an essential tool for nutrition specialists to effectively evaluate nutritional status and monitor progression during dietary interventions. As humans age, there is a natural increase in fat mass coupled with a gradual decline in lean mass, specifically in bone and muscle mass. Individuals with a high body fat percentage are at a greater risk of cardiovascular diseases, type 2 diabetes, several types of cancer, and early mortality. Significant decreases in bone mineral density signify osteopenia and osteoporosis, while reductions in skeletal muscle mass increase the risk of developing sarcopenia. Moreover, undernutrition exacerbates the effects of many medical conditions and is important to address. Though weight tracking and calculation of BMI are used commonly by clinicians and dietitians, these measures do not provide insight on the relative contributions of fat mass and fat-free mass or the changes in these compartments that may reflect disease risk. Therefore, it is important that healthcare professionals have a critical understanding of body composition assessment and the strengths and limitations of the methods available.

27 September 2018 in Sports
Verified
Journal Article
Open access
PDF file
Michael R. EscoMichael R. Esco
Michael R. Esco
MFMichael V. Fedewa
Michael V. Fedewa
ZCZackary S. Cicone
Zackary S. Cicone
OSOleg Sinelnikov
Oleg Sinelnikov
Damir SekulicDamir Sekulic
Damir Sekulic
CHClifton J Holmes
Clifton J Holmes
The primary aim of this study was to determine the association between body composition and performance outcomes in youth soccer players. Twenty-five competitive male youth soccer players (age = 13.7 ± 0.8 years, height = 167.4 ± 9.7 cm, weight = 57.6 ± 12.1 kg) volunteered to participate in this study. Height and weight were used to calculate body mass index (BMI). Body fat percentage (BF%) and fat-free mass (FFM) were determined with dual-energy X-ray absorptiometry. Each athlete performed the Pacer test, vertical jump, and t-test drill. Participants were predominantly normal weight (20.4 ± 2.7 kg·m−2). The body composition results were 20.3 ± 4.9% for BF% and 46.5 ± 8.7 kg for FFM. The results of the performance tests indicated a mean ± standard deviation (SD) of 1418 ± 332 m for Pacer, 57.2 ± 7.4 cm for vertical jump, 11.6 ± 0.7 s for t-test. Body mass index was not associated with any performance measure (r = 0.02 to −0.21, all p > 0.05). Body fat percentage was associated with the Pacer, vertical jump, and t-test (r = −0.62, −0.57, 0.61, respectively; all p < 0.01) and remained after accounting for BMI. Fat-free mass was only significantly related to t-test (r = −0.43, p < 0.01). However, after controlling for BMI, FFM was related to all three performance tests. Body fat percentage and FFM are associated with performance in youth soccer players, with stronger relationships reported in the former metric. The findings highlight the need for accurate body composition measurements as part of an assessment battery in young athletes.

28 October 2021 in Journal of Clinical Medicine
Verified
Journal Article
Open access
PDF file
CHClifton J Holmes
Clifton J Holmes
MHMary Hastings
Mary Hastings
Diabetic peripheral neuropathy (DPN) is the presence of symptoms and/or signs of peripheral nerve dysfunction in people with diabetes after the exclusion of other causes. It is associated with pain, paresthesia, sensory loss, muscle atrophy with fat infiltration, and muscular dysfunction typically starting distally in the feet and progressing proximally. Muscle deterioration within the leg and foot can lead to muscle dysfunction, reduced mobility, and increases the risk of disability, ulceration, and amputation. Exercise training is an established method for increasing the different components of physical fitness, including enhancing body composition and improving neuromuscular strength. A number of experimental studies have utilized exercise training to treat various impairments associated with DPN, such as nerve conduction velocity, pain tolerance, and balance. However, the broad spectrum of exercise training modalities implemented and differences in target outcome measurements have made it difficult to understand the efficacy of exercise training interventions or provide appropriate exercise prescription recommendations. Therefore, the aims of this review were to (1) briefly describe the pathophysiology of DPN and (2) discuss the effects of exercise training interventions on sensorimotor, metabolic, and physical functions in people with DPN.

9 October 2020 in Sensors
Verified
Journal Article
Open access
PDF file
CHClifton J Holmes
Clifton J Holmes
MFMichael V. Fedewa
Michael V. Fedewa
Lee WinchesterLee Winchester
Lee Winchester
HMHayley Vanessa MacDonald
Hayley Vanessa MacDonald
SWStefanie A. Wind
Stefanie A. Wind
Michael R. EscoMichael R. Esco
Michael R. Esco
The aim was to examine the validity of heart rate variability (HRV) measurements from photoplethysmography (PPG) via a smartphone application pre- and post-resistance exercise (RE) and to examine the intraday and interday reliability of the smartphone PPG method. Thirty-one adults underwent two simultaneous ultrashort-term electrocardiograph (ECG) and PPG measurements followed by 1-repetition maximum testing for back squats, bench presses, and bent-over rows. The participants then performed RE, where simultaneous ultrashort-term ECG and PPG measurements were taken: two pre- and one post-exercise. The natural logarithm of the root mean square of successive normal-to-normal (R-R) differences (LnRMSSD) values were compared with paired-sample t-tests, Pearson product correlations, Cohen’s d effect sizes (ESs), and Bland–Altman analysis. Intra-class correlations (ICC) were determined between PPG LnRMSSDs. Significant, small–moderate differences were found for all measurements between ECG and PPG: BasePre1 (ES = 0.42), BasePre2 (0.30), REPre1 (0.26), REPre2 (0.36), and REPost (1.14). The correlations ranged from moderate to very large: BasePre1 (r = 0.59), BasePre2 (r = 0.63), REPre1 (r = 0.63), REPre2 (r = 0.76), and REPost (r = 0.41)—all p < 0.05. The agreement for all the measurements was “moderate” (0.10–0.16). The PPG LnRMSSD exhibited “nearly-perfect” intraday reliability (ICC = 0.91) and “very large” interday reliability (0.88). The smartphone PPG was comparable to the ECG for measuring HRV at rest, but with larger error after resistance exercise.

CHClifton J Holmes
Clifton J Holmes
Susan Beth RacetteSusan Beth Racette
Susan Beth Racette
LSLeslie June Symonds
Leslie June Symonds
AAAna Maria Arbeláez
Ana Maria Arbeláez
CCChao Cao
Chao Cao
AGAndrea Granados
Andrea Granados
The aims of this study were to (1) determine the feasibility of a home-based resistance exercise training (RET) program in patients with cystic fibrosis and impaired glucose tolerance using virtual personal training and (2) observe the effects completion of the RET program had on glucose metabolism, pulmonary function, body composition, and physical fitness. The feasibility of the program was defined as 80% compliance. Ten participants (15.80 ± 2.20 yr, 25.1 ± 7.4 kg/m2) began a home-based resistance training program consisting of 36 sessions supervised via online videoconferencing. Compliance scores of 78.9% (all participants) and 81.8% (without one outlier) were observed. A significant increase was observed in 2-h C-peptide levels (2.1 ng/mL; p = 0.04), with a moderate decrease in fasting glucose (−5.2 mg/dL; p = 0.11) and a moderate increase in 2-h insulin (35.0 U/mL; p = 0.10). A small decrease in the fat percentage (−1.3%; p = 0.03) was observed in addition to increases in fat-free mass (1.5 kg; p = 0.01) and the fat-free mass index (0.4; p = 0.01). Small, yet statistically significant increases were observed in V̇O2peak (0.1 L/min p = 0.01), V̇CO2peak (0.1 L/min; p = 0.01), and ventilation (5.3 L/min; p = 0.04). Telehealth-based RET is feasible in adolescents with CF and impaired glucose tolerance and elicits small yet favorable changes in insulin secretion, body composition, and exercise capacity.

1 May 2020 in The Journal of High Technology Management Research
Verified
Journal Article
Closed access
CHClifton J Holmes
Clifton J Holmes
MFMichael V. Fedewa
Michael V. Fedewa
WDWard C. Dobbs
Ward C. Dobbs
YLYuan Liu
Yuan Liu
AFAndrew A. Flatt
Andrew A. Flatt
MEMichael R. Esco
Michael R. Esco