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Qin Liu
College of Food Science and Engineering, Nanjing University of Finance and Economics, Nanjing 210023, China

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Journal article
Published: 16 August 2021 in Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology
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Bisphenol B (BPB), a widely used alternative of bisphenol A (BPA), has been detected in various environmental media and foodstuffs. However, the knowledge of the health risks about BPB is still limited. In this study, the effects of BPB on thyroid hormone homeostasis and neuronal development were evaluated by exposure of embryos 2 h post-fertilization (hpf) to BPB (0, 1, 10, 100 and 1000 μg/L) until 144 hpf. The results showed that 100 and 1000 μg/L BPB exposed larvae exhibited abnormal morphologies in phenotype and brain histological patterns. Significant decline of thyroid hormone thyroxine (T4) content and elevation of 3,5,3′-triiodothyronine (T3) content, along with the up-regulated expression of tg, trhr1, dio1, dio2, thrα, thrβ genes and down-regulated expression of tsh, ttr and trh genes in BPB exposed zebrafish larvae were observed. Moreover, locomotor activity of larvae was decreased, and the transcription of genes (e.g., elavl3, gap43, zn5, α-tubulin, syn2a and mbp) related to neuronal development were inhibited after exposure to BPB. The mechanism of neurotoxicity and thyroid disruption in zebrafish larvae induced by BPB were discussed.

ACS Style

Qian Yang; Zhenzhu Zhu; Qin Liu; Lihong Chen. Adverse effects of bisphenol B exposure on the thyroid and nervous system in early life stages of zebrafish. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 2021, 250, 109167 .

AMA Style

Qian Yang, Zhenzhu Zhu, Qin Liu, Lihong Chen. Adverse effects of bisphenol B exposure on the thyroid and nervous system in early life stages of zebrafish. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology. 2021; 250 ():109167.

Chicago/Turabian Style

Qian Yang; Zhenzhu Zhu; Qin Liu; Lihong Chen. 2021. "Adverse effects of bisphenol B exposure on the thyroid and nervous system in early life stages of zebrafish." Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 250, no. : 109167.

Journal article
Published: 01 January 2020 in Journal of Medicinal Food
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Anthocyanin-rich extracts have shown anti-inflammation activity in mouse colitis models. Cyanidin-3-glucoside (C3G) is one of the widespread anthocyanins in plants, and cyanidin (Cy) is the aglycone of C3G that can be generated in intestine under gut microorganism metabolism. To explore the anti-inflammatory activity of single anthocyanins compound and show the potential mechanism, the protective effects of C3G and its aglycone Cy on 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in mice and lipopolysaccharide (LPS)-stimulated Caco-2 cellular monolayer inflammation were studied. The results showed that both C3G and Cy significantly improved the clinical symptoms and relieved the histological damage in TNBS-challenged mice. The activity of myeloperoxidase and the excretion of inflammatory cytokines tumor necrosis factor-α, interleukin-1β, interleukin-6, and interferon-γ were also significantly inhibited at the administration dosage of 200 μmol/kg. In vitro studies showed that when LPS-stimulated Caco-2 cells were pretreated with C3G and Cy, the destruction of the intestinal epithelial barrier was ameliorated due to the improvement of the transepithelial electrical resistance and Lucifer yellow flux values, while there were no significant difference between C3G and Cy groups at the same dosage. Similarly, both C3G and Cy suppressed nitric oxide production and inflammatory cytokines secretion of LPS-induced Caco-2 cells. C3G and its aglycone Cy had similar anti-inflammatory activity in both colitis mice and Caco-2 cells. The results suggest that C3G and Cy may exert anti-inflammatory effects by protecting the intestinal barrier as well as by suppressing inflammatory cytokine secretion. Thus, C3G or Cy could be potential preventive agents or supplementary medicines for inflammatory bowel disease.

ACS Style

Yuanruo Gan; Yong Fu; Lipin Yang; Jiangning Chen; Hong Lei; Qin Liu. Cyanidin-3-O-Glucoside and Cyanidin Protect Against Intestinal Barrier Damage and 2,4,6-Trinitrobenzenesulfonic Acid-Induced Colitis. Journal of Medicinal Food 2020, 23, 90 -99.

AMA Style

Yuanruo Gan, Yong Fu, Lipin Yang, Jiangning Chen, Hong Lei, Qin Liu. Cyanidin-3-O-Glucoside and Cyanidin Protect Against Intestinal Barrier Damage and 2,4,6-Trinitrobenzenesulfonic Acid-Induced Colitis. Journal of Medicinal Food. 2020; 23 (1):90-99.

Chicago/Turabian Style

Yuanruo Gan; Yong Fu; Lipin Yang; Jiangning Chen; Hong Lei; Qin Liu. 2020. "Cyanidin-3-O-Glucoside and Cyanidin Protect Against Intestinal Barrier Damage and 2,4,6-Trinitrobenzenesulfonic Acid-Induced Colitis." Journal of Medicinal Food 23, no. 1: 90-99.

Journal article
Published: 20 September 2019 in Antioxidants
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The contents of total phenolics (TPC), individual phenolic acid and antioxidant activities in the free and bound fractions of potato with different flesh colors were systematically investigated. The TPC and antioxidant capacity in the bound fraction was significantly lower than that in the free fraction. Chlorogenic acid, neochlorogenic acid, cryptochlorogenic acid, caffeic acid, p-coumaric acid and ferulic acid were detected in the free fraction with chlorogenic acid being the most predominant, accounting for 35.21–81.78% of the total content. Caffeic acid, p-coumaric acid and ferulic acid were detected in the bound fraction in the colored potato with caffeic acid being the major one. In the free fraction, the content of each individual phenolic acid had positive correlation with antioxidant activity. In the bound fraction, caffeic acid and p-coumaric acid showed positive correlation with antioxidant activity. This study promotes further understanding of the correlations among TPC, phenolic acids and antioxidant activity.

ACS Style

Weidong Ru; Yuehan Pang; Yuanruo Gan; Qin Liu; Jinsong Bao; Ru; Pang; Gan; Liu; Bao. Phenolic Compounds and Antioxidant Activities of Potato Cultivars with White, Yellow, Red and Purple Flesh. Antioxidants 2019, 8, 419 .

AMA Style

Weidong Ru, Yuehan Pang, Yuanruo Gan, Qin Liu, Jinsong Bao, Ru, Pang, Gan, Liu, Bao. Phenolic Compounds and Antioxidant Activities of Potato Cultivars with White, Yellow, Red and Purple Flesh. Antioxidants. 2019; 8 (10):419.

Chicago/Turabian Style

Weidong Ru; Yuehan Pang; Yuanruo Gan; Qin Liu; Jinsong Bao; Ru; Pang; Gan; Liu; Bao. 2019. "Phenolic Compounds and Antioxidant Activities of Potato Cultivars with White, Yellow, Red and Purple Flesh." Antioxidants 8, no. 10: 419.

Article
Published: 28 February 2018 in Chemistry – A European Journal
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We report a detailed NMR and DFT study of the interaction of polynuclear platinum anticancer agents (PPCs) with negatively charged phospholipids as a mechanism for their cellular uptake. The reactions of fully 15N-labelled [{trans-PtCl(NH3)2}2(-trans-Pt(NH3)2{NH2(CH2)6NH2}2)]4+ (15N-1, 1,0,1/t,t,t) and the dinuclear [{trans-PtCl(NH3)2}2{-H2N(CH2)6NH2}]2+ (15N-2, 1,1/t,t) with the sodium salt of 1,2-dihexanoyl-sn-glycero-3-phosphate (DHPA) were studied at 298 K, pH ~5.4, by [1H,15N] HSQC 2D NMR spectroscopy. Both 15N-1 and -2 form an initial mono-adduct in which the DHPA is coordinated via the phosphate O atom. For the dinuclear 15N-2, coordination of a second DHPA, in two different orientations, leads to two conformers of the bifunctional adduct. For 15N-1, coordination of the second DHPA allows the central {PtN4} coordination unit to bind electrostatically to two additional DHPA molecules via phosphate clamp interactions, in an extended network. For both 1,0,1/t,t,t (1) and 1,1/t,t (2), equilibrium conditions are obtained more slowly (> 35 h) than in the presence of phosphate (12 h) and in each case the rate constant for the first step of DHPA binding (kL) is about 8 times higher than that for phosphate, whereas the rate constants for the reverse reactions are quite similar. Reaction of 15N-1 with the sodium salt of 1,2-dihexanoyl-sn-glycero-3-[phosphatidyl-L-serine] (DHPS) showed only minor adduct formation via coordination to the N-donor atom of the phosphoserine group

ACS Style

Anil Kumar Gorle; Junyong Zhang; Qin Liu; Susan J. Berners‐Price; Nicholas P. Farrell. Structural Factors Affecting Binding of Platinum Anticancer Agents with Phospholipids: Influence of Charge and Phosphate Clamp Formation. Chemistry – A European Journal 2018, 24, 4643 -4652.

AMA Style

Anil Kumar Gorle, Junyong Zhang, Qin Liu, Susan J. Berners‐Price, Nicholas P. Farrell. Structural Factors Affecting Binding of Platinum Anticancer Agents with Phospholipids: Influence of Charge and Phosphate Clamp Formation. Chemistry – A European Journal. 2018; 24 (18):4643-4652.

Chicago/Turabian Style

Anil Kumar Gorle; Junyong Zhang; Qin Liu; Susan J. Berners‐Price; Nicholas P. Farrell. 2018. "Structural Factors Affecting Binding of Platinum Anticancer Agents with Phospholipids: Influence of Charge and Phosphate Clamp Formation." Chemistry – A European Journal 24, no. 18: 4643-4652.