Unmanned aerial vehicles (UAVs) have emerged as a pivotal technology for enhancing the agility and resilience of future wireless networks. However, conventional optimization approaches remain predominantly reactive, relying solely on current network conditions for decision making. This proves to be inadequate for handling sudden traffic surges in dynamic environments, resulting in suboptimal service quality. To address this limitation, this paper proposes a novel joint optimization framework integrating spatiotemporal traffic prediction. This equips UAVs with predictive capabilities, thereby facilitating a paradigm shift from passive response to proactive service provision. The main contributions of this work are fourfold: First, a novel closed-loop optimization framework is introduced, deeply integrating an advanced traffic-forecasting module with a communication resource optimization module to provide a systematic, forward-looking decision-making solution for UAV-assisted communications. Second, a cellular traffic predictor based on Gaussian mixture model meta-learning (GMM-ML) is designed. This model effectively captures the periodicity and heterogeneity of traffic data, enabling the precise prediction of future hotspot areas and resolving the challenge of accurate forecasting under small-sample conditions. Third, a long-term discounted mixed-integer nonlinear programming (MINLP) problem model is formulated. This innovatively incorporates a “service readiness reward” for predicted hotspots within the objective function to achieve long-term performance optimization. Fourth, an efficient and convergent predictive iterative association and location optimization (P-IALO) algorithm is developed. Utilizing block coordinate descent and continuous convex approximation techniques, this algorithm decomposes the original complex problem to alternately optimized subproblems of user association and trajectory planning, guaranteeing algorithmic convergence. To validate the effectiveness of the proposed framework, large-scale simulation experiments were conducted using real-world traffic data. The results demonstrate that compared to traditional reactive algorithms, the proposed scheme significantly enhances the overall system throughput by 12%, improves user QoS satisfaction by 9.4%, and reduces service interruptions by 34.2%. Concurrently, the algorithm exhibits favorable convergence speed and robustness, maintaining performance advantages even under predictive errors. Extensive experimentation thoroughly demonstrates the efficacy of this research in enhancing the performance of drone-assisted networks.