Background: Traumatic sciatic nerve injuries are functionally devastating and surgically demanding, yet no single center accumulates enough cases to draw reliable conclusions about mechanism-specific outcomes or optimal surgical timing. Despite a growing body of literature, no bibliometric study has specifically mapped the scientific output on this topic in relation to trauma mechanism, operative decision-making, and functional recovery. Methods: A descriptive bibliometric study was conducted. Web of Science, Scopus, and PubMed/MEDLINE were searched for original articles and reviews published in English between January 2015 and December 2025 using predefined Boolean search strings. Records were selected through a PRISMA 2020-compliant process. Performance analysis and science mapping were performed in Biblioshiny (bibliometrix R package) and VOSviewer. Correlational statistics were performed in IBM SPSS Statistics version 27. Results: A total of 416 publications met the inclusion criteria, distributed across 288 journals. Annual output ranged from 32 to 42 publications per year, with a cumulative total of 416 papers over the decade. Germany ( n = 28; 6.7%), Turkey ( n = 25; 6.0%), and India ( n = 22; 5.3%) were the most productive countries. Motor vehicle accidents ( n = 89; 28.4%) and gunshot wounds ( n = 71; 22.6%) were the leading mechanisms identified in full-text review. Among surgically treated cases, neurolysis (64%), sural nerve autografting (32%), and primary end-to-end neurorrhaphy (4%) were the dominant interventions. Surgery within six months of injury was the most consistent predictor of good motor recovery across all technique categories. Conclusions: This bibliometric analysis maps, for the first time, the mechanism-based surgical literature on traumatic sciatic nerve injuries and identifies persistent gaps in standardized outcome reporting and prospective comparative data. We recommend multicenter registries incorporating validated patient-reported outcome instruments and prospective comparison of penetrating versus blunt injury cohorts as the most actionable priorities for the field.

Glioblastoma (GBM) remains difficult to treat because of its aggressive growth and resistance to current therapies. This study evaluated the individual and combined effects of sulforaphane (SFN) and Centella asiatica (CA) in T98G glioblastoma cells. Relative cell viability was assessed using the MTT assay after 24-h treatment, and combination effects were explored using descriptive Bliss independence analysis. Wound-healing and colony formation assays assessed wound closure and clonogenic capacity. Immunocytochemistry was used to evaluate p-Akt, p-mTOR, Ki-67, cleaved caspase-3, and Beclin-1, while extracellular total oxidant status and lactate were measured using commercial kits. Experiments were performed in three independent biological replicates. CA reduced MTT-based relative viability, whereas SFN produced increased signals at low concentrations and decreased signals at higher concentrations. Combo A (10 µM SFN + 50 µg/mL CA) yielded 36.56% relative viability and the largest positive excess over Bliss (15.23 percentage points), suggesting a potential synergistic interaction. Combo A significantly reduced viability compared with control and CA alone, but not matched-dose SFN. Percentage wound closure did not differ significantly among the groups at 6 or 24 h. Combo A also reduced colony formation compared with control (p = 0.030) and p-mTOR immunoreactivity compared with CA alone. No significant differences were detected in the remaining markers, oxidant status, or lactate. These findings provide a basis for further studies on the combined effects of SFN and CA and the molecular processes underlying the treatment response. Validation in additional cell lines and in vivo models is needed.