Amaç: Lomber spinal kanal darlığı (LSKD), dekompresyon cerrahisi gerektiren sık görülen bir durumdur, ancak tedavide farklı cerrahi yaklaşımlar vardır. Bu çalışmanın amacı, tek seviyeli LSKD için tek taraflı yaklaşımla iki taraflı dekompresif lomber laminektomi (TYİDL) açık iki taraflı dekompresif lomber laminektominin (AiDL) sonuçlarını karşılaştırmaktır. Yöntem: Ekim 2016 ile Mayıs 2023 arasında tek seviyeli LSS için operasyon geçiren 198 ardışık hasta retrospektif olarak değerlendirildi. Seksen hastaya TYİDL, 118 hastaya AiDL uygulandı. Tüm hastalarda ameliyat öncesi ve 6 ay sonrasında Visual Analog Skala (VAS) skorları ve yürüme süreleri kaydedildi. Operasyon süresi, operasyon komplikasyonları, hastanede kalış süresi, operasyon sırasındaki kan kaybı ve iatrojenik spondilolistezis oranları ölçüldü. Bulgular: Çalışmaya dahil edilen hastaların yaş ortalaması 62.38±12.5 yıldı. TYİDL ve AiDL geçiren hastalar arasında VAS skorları, yürüme süreleri, ameliyat süreleri, ameliyat komplikasyonları ve takiplerinde iatrojenik spondilolistezis açısından istatistiksel olarak anlamlı bir fark yoktu (p > 0.05). Ancak, TYİDL geçiren hastalarda operasyon sırasındaki toplam kan kaybı ve hastanede kalış süresi, AİDL geçiren hastalara göre anlamlı olarak daha kısaydı (p

Glioblastoma (GBM) remains difficult to treat because of its aggressive growth and resistance to current therapies. This study evaluated the individual and combined effects of sulforaphane (SFN) and Centella asiatica (CA) in T98G glioblastoma cells. Relative cell viability was assessed using the MTT assay after 24-h treatment, and combination effects were explored using descriptive Bliss independence analysis. Wound-healing and colony formation assays assessed wound closure and clonogenic capacity. Immunocytochemistry was used to evaluate p-Akt, p-mTOR, Ki-67, cleaved caspase-3, and Beclin-1, while extracellular total oxidant status and lactate were measured using commercial kits. Experiments were performed in three independent biological replicates. CA reduced MTT-based relative viability, whereas SFN produced increased signals at low concentrations and decreased signals at higher concentrations. Combo A (10 µM SFN + 50 µg/mL CA) yielded 36.56% relative viability and the largest positive excess over Bliss (15.23 percentage points), suggesting a potential synergistic interaction. Combo A significantly reduced viability compared with control and CA alone, but not matched-dose SFN. Percentage wound closure did not differ significantly among the groups at 6 or 24 h. Combo A also reduced colony formation compared with control (p = 0.030) and p-mTOR immunoreactivity compared with CA alone. No significant differences were detected in the remaining markers, oxidant status, or lactate. These findings provide a basis for further studies on the combined effects of SFN and CA and the molecular processes underlying the treatment response. Validation in additional cell lines and in vivo models is needed.

Traumatic spinal cord injury (SCI) is among the most disabling neurological injuries, frequently producing permanent motor, sensory, and autonomic impairment, lifelong dependence on health care, an...

Objective: The approaches in posterior fossa surgery are used for accessing various tumors and vascular lesions including neuro-glial tumors, vestibular Schwannomas, inclusion tumors, meningiomas. Materials and Methods: A total of 62 patients who underwent operation due to infra-tentorial intra-cranial mass lesion in Neuro-Surgery Clinic between 2014 and 2018 were included in the study. Result: The study was conducted with 62 patients of whom 61.3% (n=38) were males and 38.72% (n=24) were females between 2014 and 2018. While 33.9% (n=21) of the patients underwent cranioplasty, 66.1% (n=41) did not undergo cranioplasty. Conclusion: The preliminary study suggests that cranioplasty is useful for headache and cerebellar ectopy however insufficient for prevention of CNF fistula development.